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Search Guest Houses in Southeast Missouri

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Check prices for these dates

Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan
In one month
16 Jan - 18 Jan
In two months
13 Feb - 15 Feb
No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Missouri

Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is HK$807
HK$912 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Front of property
The Farmstead Hotel

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is HK$665
HK$756 total
includes taxes & fees
20 Dec - 21 Dec
The Farmstead Hotel
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1005)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is HK$588
HK$670 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Sikeston
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (669)
"Great place "
United States
GUY
The price is HK$655
HK$709 total
includes taxes & fees
20 Dec - 21 Dec
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is HK$778
HK$872 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn Poplar Bluff
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is HK$724
HK$819 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is HK$432
HK$492 total
includes taxes & fees
21 Dec - 22 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is HK$700
HK$805 total
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1000)
"Love the updated rooms and the vending area."
United States
Kathi
The price is HK$591
HK$624 total
includes taxes & fees
21 Dec - 22 Dec
Motel 6 Poplar Bluff, MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is HK$700
HK$790 total
includes taxes & fees
23 Dec - 24 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (445)
"Friendly staff clean rooms "
United States
Christopher
The price is HK$759
HK$860 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston
Children’s play area – outdoor
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is HK$742
HK$805 total
includes taxes & fees
20 Dec - 21 Dec
Honeysuckle Inn - Mountain View
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is HK$902
HK$1,023 total
includes taxes & fees
28 Dec - 29 Dec
Courtyard by Marriott Cape Girardeau Downtown
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (886)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is HK$721
HK$824 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lobby sitting area
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (911)
"Vary clean"
United States
George
The price is HK$589
HK$688 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn Festus - St Louis South
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is HK$739
HK$834 total
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is HK$646
HK$683 total
includes taxes & fees
21 Dec - 22 Dec
Drury Inn & Suites Jackson MO
Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (726)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Front of property
Echo Bluff State Park

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is HK$1,138
HK$1,204 total
includes taxes & fees
21 Dec - 22 Dec
Echo Bluff State Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

10/10 Excellent
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
Mindy 1-night trip
Posted 17 hours ago
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Find out more about Southeast Missouri

Southeast Missouri Guest Houses information

Number of reviews
14,244
Accommodation
0 Guest Houses
Lowest Price
HK$492
Highest Price
HK$1,204