Best Southeast Missouri Hotels in 2026 from HK$492 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Hot tub

Apartment

Pool

Cabin

Family friendly

Waterpark

Cottage

Farm

Condo

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Our top choices for Southeast Missouri hotels

Hotel

Breakfast included

Cabin

Reserve now, pay later

Hot tub

1. Drury Inn & Suites Jackson MO

Jackson

Jamie

HK$651

HK$688 total

includes taxes & fees

30 Aug - 31 Aug

2. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Joy

HK$784

HK$884 total

includes taxes & fees

13 Sept - 14 Sept

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Arsenia

HK$793

HK$896 total

includes taxes & fees

7 Sept - 8 Sept

Desk, soundproofing, free WiFi, bed sheets

4. Shepherd Mountain Inn

Ironton

Katie

HK$966

HK$1,055 total

includes taxes & fees

21 Sept - 22 Sept

Indoor pool, open 8 AM to 11 PM, pool loungers

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

HK$799

HK$902 total

includes taxes & fees

24 Sept - 25 Sept

Desk, blackout curtains, rollaway beds, free WiFi

6. Fort Davidson Hotel

Ironton

richard

HK$980

HK$1,070 total

includes taxes & fees

13 Sept - 14 Sept

7. Hampton Inn Poplar Bluff

Poplar Bluff

Philip

HK$733

HK$821 total

includes taxes & fees

13 Sept - 14 Sept

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

HK$792

HK$897 total

includes taxes & fees

13 Sept - 14 Sept

9. Hampton Inn Sikeston

Sikeston

Jeffrey

HK$804

HK$910 total

includes taxes & fees

13 Sept - 14 Sept

Hypo-allergenic bedding, desk, laptop workspace, blackout curtains

10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Shawn

HK$693

HK$750 total

includes taxes & fees

27 Aug - 28 Aug

Desk, blackout curtains, iron/ironing board, free cots/infant beds

11. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

HK$737

HK$847 total

includes taxes & fees

30 Aug - 31 Aug

Desk, blackout curtains, iron/ironing board, rollaway beds

12. Crown Pointe Lodge, BW Signature Collection

Farmington

Louise

HK$860

HK$936 total

includes taxes & fees

6 Sept - 7 Sept

Desk, laptop workspace, blackout curtains, free cots/infant beds

13. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Bonnie

HK$564

HK$636 total

includes taxes & fees

31 Aug - 1 Sept

Desk, iron/ironing board, free WiFi, bed sheets

14. Madison Inn Lodge

Fredericktown

Christine

HK$686

HK$749 total

includes taxes & fees

10 Sept - 11 Sept

15. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

michael

HK$823

HK$932 total

includes taxes & fees

30 Aug - 31 Aug

16. Tru By Hilton Cape Girardeau

Cape Girardeau

Gwendolyn

HK$700

HK$797 total

includes taxes & fees

3 Sept - 4 Sept

17. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

HK$791

HK$861 total

includes taxes & fees

26 Aug - 27 Aug

18. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Heather

HK$793

HK$894 total

includes taxes & fees

3 Sept - 4 Sept

In-room safe, desk, iron/ironing board, free cots/infant beds

19. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

HK$829

HK$935 total

includes taxes & fees

2 Sept - 3 Sept

20. Super 8 by Wyndham Farmington

Farmington

Saundra

HK$466

HK$508 total

includes taxes & fees

20 Sept - 21 Sept

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Holiday Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cabin

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Holiday Home

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

55-inch Smart TV with digital channels, TV, streaming services

Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

"Beautiful place enjoyed our stay"

Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A waterfall, a river, and a red building in a forested area.

Current River State Park

9.2/10 (20 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good

"It was a nice stay"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"The room was clean and quiet. Staff was friendly and professional and helpful. Breakfast was very good with plenty of options. Second time I have stayed here and felt safe as a woman traveling with her daughter. Only minor complaint is that the pillows aren't the best. Recommend bringing your own from home if you can."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Clean rooms, friendly staff, I would definitely stay here again next time I’m in town."

The Riverview

8/10 Good

"Nice view of the river. The staff was nice."

Comfort Inn Festus - St Louis South

10/10 Excellent

"Clean. friendly staff good location"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great value, very clean and breakfast was actually good."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"We stay here every time we are in Sikesons. Can't beat this hotel. Super clean 'comfortable!' beds, living room area, and bathrooms. Small hot breakfast. All for the best price out there. Don't skip on this hotel! Staff is always polite and helpful. We always love to walk out to the pond"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Clean room"

Motel 6 Poplar Bluff, MO

8/10 Good

"Clean and nice."

More cheap stays in Southeast Missouri