Photo by Bill Dillard
Southeast Missouri 2 Stars Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri 2 Star Hotels
Our top choices for Southeast Missouri 2-star hotels
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1008)
"Room was clean , staff was friendly !"
Sally
The price is HK$417
HK$474 total
includes taxes & fees
10 Jan - 11 Jan 2026
8.0 out of 10, Very good, (1004)
"It was a nice stay."
Rebecca
The price is HK$591
HK$647 total
includes taxes & fees
30 Dec - 31 Dec
7.2 out of 10, Good, (1005)
"Everything was excellent. Verify happy with everything. Stayed 3 weeks for work and already booked 2 more stays."
James
The price is HK$489
HK$557 total
includes taxes & fees
4 Jan - 5 Jan 2026
9.0 out of 10, Wonderful, (1004)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
Colleen
The price is HK$544
HK$614 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian
The price is HK$707
HK$798 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (861)
"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "
Terry
The price is HK$808
HK$913 total
includes taxes & fees
9 Jan - 10 Jan 2026
8.8 out of 10, Excellent, (465)
"Clean room, very nice staff"
Mack
The price is HK$664
HK$756 total
includes taxes & fees
30 Dec - 31 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical CenterCape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
Arthur
The price is HK$544
HK$614 total
includes taxes & fees
2 Jan - 3 Jan 2026
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 3-star hotels
Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Southeast Missouri.
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
The price is HK$699 per night from 4 Jan to 5 Jan
HK$699
HK$789 total
4 Jan - 5 Jan 2026
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
Still don't see what you're looking for?
See all properties in Southeast Missouri.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Motel 6 Poplar Bluff, MO
10/10 Excellent
Explore a world of travel with Expedia
- Lodges in Eminence
- Dexter Hotels
- Cabin Rentals in Doniphan
- Hotels near Hawn State Park
- 5 Star Hotels in Oran
- Bar Hotel Hotels in Ste Genevieve
- Apartments in Arcadia
- Spa Hotel Hotels in Southeast Missouri
- Hotel with Pool Hotels in Bonne Terre
- Fredericktown Hotels
- Cabin Rentals in Qulin
- Cabin Rentals in Van Buren
- Cabin Rentals in Wappapello
- Bunker Hotels
- Motels in Ellington
- Qulin Hotels
- Park Hills Hotels
- Scott County Hotels
- Valles Mines Hotels
- 4 Star Hotels in Potosi
- Poplar Bluff Hotels
- Cabin Rentals in Poplar Bluff
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Motels in Oran
- 4 Star Hotels in Cadet
- Apartments in Farmington
- Hotels near Powder Mill Cave Natural Area
- 5 Star Hotels in Leadwood
- Annapolis Hotels
- Hotels near Dillard Mill State Historic Site
- Pet-Friendly Hotel Hotels in Farmington
- Cabin Rentals in St Mary
- Hotels near Echo Bluff State Park
- Cheap Hotels in Sikeston
- Marble Hill Hotels
- Spa Hotel Hotels in De Soto
- Hotels near Felix Valle House State Historic Site
- 3 Star Hotels in Park Hills
- Doniphan Hotels
- B&B in Black
- Motels in Fredericktown
- Cottages in New Offenburg
- Apartments in Eminence
- Hotels near Silver Mine Recreation Area
- Vacation Homes in Qulin
- Drury Inn & Suites Hotels in Sikeston
- Hotels near Current River State Park
- Hotels near K Bridge Recreation Area
- Hilton Hotels in New Offenburg
- Hotels near Trail of Tears State Park
- Historic Hotel Hotels in Southeast Missouri
- Apartments in Ste Genevieve
- Winery Hotel Hotels in Ste Genevieve
- Hotels near eDen Spa & Salon
- Hotels near Missouri Mines State Historic Site
- Cabin Rentals in Sikeston
- Romantic Hotel Hotels in Southeast Missouri
- Independent Hotels in Qulin
- Cabin Rentals in Cadet
- Hotels near Johnson's Shut-ins State Park
- 4 Star Hotels in Oran
- Cabin Rentals in Annapolis
- Black Hotels
- Desloge Hotels
- La Quinta Inn & Suites Hotels in Farmington
- Oran Hotels
- Tiff Hotels
- Cheap Hotels in Poplar Bluff
- Pet-Friendly Hotel Hotels in Dexter
- B&B in Middle Brook
- 3 Star Hotels in Valles Mines
- Farmington Hotels
- Hotels near St. Francois State Park
- Hotels near Elephant Rocks State Park
- Hotels near Taum Sauk Mountain State Park
- Bar Hotel Hotels in Poplar Bluff
- Business Hotel Hotels in Farmington
- Pet-Friendly Hotel Hotels in Poplar Bluff