Southeast Missouri

Travel Guide

A group of men in red uniforms with gold accents, holding rifles and wearing kilts.
A river flowing through a rocky landscape with dense green forest in the background.
A rocky river with clear water flowing over rocks.
A rocky shoreline with a calm lake and distant islands.
A river running through a forested landscape with a dirt road parallel to the river.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is HK$784 per night from 20 Sept to 21 Sept
HK$784
HK$885 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Plaza Hotel Cape Girardeau Conference Center
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
The price is HK$590 per night from 11 Oct to 12 Oct
HK$590
HK$689 total
11 Oct - 12 Oct
includes taxes & fees
Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...
Comfort Inn Festus - St Louis South
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
The price is HK$565 per night from 20 Sept to 21 Sept
HK$565
HK$637 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,005 reviews)
"Didn't notice bathroom venting."

Reviewed on 13 Sept 2026

Pear Tree Inn Cape Girardeau West
See all 693 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios and climate control.
10/10 Exceptional! (104 reviews)
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope ..."

Reviewed on 12 Sept 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
9.4/10 Exceptional! (6 reviews)
"This a cabin in a state park. It was very clean and had newer upgrades. Bring the food you need because it's fairly distance from a grocery. We came later in the day because we needed one night and this was a great price and not a chain hotel which we like. There is a little store not too far from ..."

Reviewed on 9 Sept 2026

Lake Wappapello
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
Stay at this holiday home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
Silo Farm Haus- located in the heart of wine country!
See all properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Things to do

Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

HK$100
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

HK$157
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Tour The Ozarks Private Springfield Brewery Tour

HK$1,676
per adult
Tour The Ozarks Private Springfield Brewery Tour
See all activities in Southeast Missouri
A cable-stayed bridge over a river with a clear sky.

Alton

A red building by a clear blue lake surrounded by trees.

Eminence

A river flowing through a rocky terrain with trees and fallen leaves.

Farmington

A swampy area with water lilies and tall trees.

Hayti

Explore a world of travel with Expedia