Photo by Bill Dillard

Southeast Missouri hotels from HK$424

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24 Dec - 25 Dec
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Our top choices for Southeast Missouri hotels

Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (857)
"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "
United States
Terry
The price is HK$809
HK$914 total
includes taxes & fees
9 Jan - 10 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is HK$700
HK$805 total
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Sikeston, MO
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (706)
"Amazing place"
United States
Mladen
The price is HK$817
HK$923 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Poplar Bluff by IHG
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is HK$700
HK$789 total
includes taxes & fees
30 Dec - 31 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Premium bedding, down duvets, pillow-top beds, in-room safe
The Farmstead Hotel

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is HK$665
HK$756 total
includes taxes & fees
25 Dec - 26 Dec
The Farmstead Hotel
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1009)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is HK$588
HK$670 total
includes taxes & fees
30 Dec - 31 Dec
Best Western Plus Sikeston
Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (797)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is HK$878
HK$983 total
includes taxes & fees
24 Jan - 25 Jan 2026
Hampton Inn Poplar Bluff
Individually decorated, individually furnished, desk, blackout curtains
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (722)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is HK$432
HK$492 total
includes taxes & fees
28 Dec - 29 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free daily buffet breakfast
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1000)
"Great stay"
United States
Heather
The price is HK$544
HK$614 total
includes taxes & fees
30 Dec - 31 Dec
Pear Tree Inn Cape Girardeau West
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (543)
"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is HK$677
HK$775 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites Perryville by IHG
Hiking
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (334)
"Staff was very friendly."
United States
Joyce
The price is HK$742
HK$804 total
includes taxes & fees
28 Dec - 29 Dec
Honeysuckle Inn - Mountain View
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1010)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is HK$645
HK$682 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Jackson MO
Front of property
Echo Bluff State Park

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is HK$1,161
HK$1,228 total
includes taxes & fees
5 Jan - 6 Jan 2026
Echo Bluff State Park
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (968)
"Nice room helpful staff. "
United States
Deborah
The price is HK$824
HK$931 total
includes taxes & fees
20 Jan - 21 Jan 2026
Drury Inn & Suites Poplar Bluff
Blackout curtains, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1000)
"It was a nice stay."
United States
Rebecca
The price is HK$591
HK$623 total
includes taxes & fees
25 Dec - 26 Dec
Motel 6 Poplar Bluff, MO
Lobby
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (911)
"Vary clean"
United States
George
The price is HK$588
HK$687 total
includes taxes & fees
27 Dec - 28 Dec
Comfort Inn Festus - St Louis South
Free daily buffet breakfast
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1001)
"Room was clean , staff was friendly !"
United States
Sally
The price is HK$411
HK$468 total
includes taxes & fees
2 Jan - 3 Jan 2026
Baymont Inn and Suites by Wyndham Farmington, MO
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (892)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is HK$721
HK$824 total
includes taxes & fees
25 Dec - 26 Dec
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Front of property
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is HK$544
HK$614 total
includes taxes & fees
30 Dec - 31 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Desk, blackout curtains, rollaway beds, free WiFi
Fort Davidson Hotel

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (174)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is HK$933
HK$1,019 total
includes taxes & fees
27 Dec - 28 Dec
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Holiday Rentals in Southeast Missouri

Holiday Home
Terrace/patio
Tiny Houses of French Village

Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (3)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
Tiny Houses of French Village
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Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
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A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"This our favorite place to stop for a good night sleep. "
Eileen 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is HK$411 per night from 2 Jan to 3 Jan
HK$411
HK$468 total
2 Jan - 3 Jan 2026
includes taxes & fees
7.8/10 Good! (1,003 reviews)

Hotels in Southeast Missouri with star-rating

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