Top Rent a Car Car Hire in James Island

Pick-up and drop-off

Same as pick-up

Pick-up time

Drop-off time

Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more.

Members save 10% more on select hotels, cars, activities and holiday rentals. Sign up.Opens in a new window

Enjoy maximum flexibility with penalty-free cancellation on most car rentals.

Heading to James Island? Explore James Island with Expedia's Travel Guides to find the best hotels, holiday packages, car hire deals and more!

Members save 10% or more on over 100,000 hotels worldwide when you’re signed in