Best Wykoff Hotels in 2026 from HK$491 - Fully Refundable Options

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Our top choices for Wykoff hotels

A lobby with leather sofas, a reception desk, a clock, and a map of the museum.

A hotel room with a large bed, a separate bathroom with a bathtub, a bedside table with a lamp, and a framed picture on the wall.

A breakfast room with wooden tables and chairs, a coffee machine, and a view of the outdoors.

A lobby with a fireplace, leather seating, a television, and a large window.

1. Americas Best Value Inn & Suites Spring Valley

Spring Valley

Donna

HK$698

HK$771 total

includes taxes & fees

24 Sept - 25 Sept

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A conference room with round tables and chairs, white walls, and a carpeted floor.

An indoor swimming pool with a checkered tile wall, a door labeled 'Mechanical Room,' and a window with a view outside.

2. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

JOSEPH

HK$644

HK$742 total

includes taxes & fees

22 Oct - 23 Oct

A reception desk with a wooden finish, a glass partition, and a blue wall with climbing plants.

A hotel room with two beds, each with white linens and patterned bedspreads. There are bedside tables with lamps, a desk with a chair, and a wall-mounted TV.

A staircase with patterned carpet and wooden handrails leading to a door marked with the number 201.

A hotel with a parking lot, a yellow food truck, and several cars parked.

3. America's Stay Inn Stewartville

Stewartville

arnold

HK$494

HK$554 total

includes taxes & fees

23 Oct - 24 Oct

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel with a covered entrance, multiple floors, and a parking lot.

4. Spark by Hilton Rochester South

Rochester

Kimberly

HK$701

HK$807 total

includes taxes & fees

28 Sept - 29 Sept

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A modern kitchen with granite countertops, a built-in microwave, and a sink. There are two wooden chairs and a small table.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

5. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Vicky

HK$738

HK$849 total

includes taxes & fees

26 Sept - 27 Sept

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

6. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Zoronna

HK$594

HK$683 total

includes taxes & fees

27 Sept - 28 Sept

A modern hotel lobby with a reception desk, seating area, and a dining space.

A hotel room with a bed, desk, chair, and a bathroom.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

7. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Melissa

HK$753

HK$867 total

includes taxes & fees

18 Oct - 19 Oct

A multi-story building with a balcony, surrounded by various potted plants and flowers.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

A porch with a variety of potted plants and flowers, a sign reading "OFFICE Welcome to Green Gables," and a door with a green doorbell.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

8. Green Gables Inn

Lanesboro

Sandra

HK$763

HK$819 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A cozy living room with a fireplace, a staircase, and a dining area.

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

9. Stone Mill Hotel & Suites

Lanesboro

Jenifer

HK$824

HK$885 total

includes taxes & fees

18 Oct - 19 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

10. Hampton Inn Rochester-South

Rochester

dennis

HK$830

HK$955 total

includes taxes & fees

30 Sept - 1 Oct

A bedroom with a sloped ceiling, a brick wall, a bed with floral bedding, two bedside lamps, and a vase with red flowers.

A building with a covered porch, a brick exterior, and a white fence.

A building with a covered porch, a swing set, and a bird sculpture.

A living room with a brick wall, a television, a refrigerator, and a coffee table.

11. Country Lodge inn

Harmony

Jacob

HK$1,148

HK$1,318 total

includes taxes & fees

24 Sept - 25 Sept

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A hotel room with two beds, a desk, a chair, and a mirror.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

12. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Jayne

HK$605

HK$696 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern hotel room with a bed, desk, and kitchenette.

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

Vickie

HK$959

HK$1,104 total

includes taxes & fees

3 Oct - 4 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern bar area with seating and a counter.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

14. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Kathy

HK$926

HK$1,066 total

includes taxes & fees

3 Oct - 4 Oct

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A compact laundry area with a washing machine, dryer, and a water fountain.

15. Econo Lodge Mayo Clinic Area

Rochester

Ashley

HK$580

HK$667 total

includes taxes & fees

11 Oct - 12 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

16. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

HK$1,036

HK$1,192 total

includes taxes & fees

2 Oct - 3 Oct

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

A coffee station with two espresso machines and a variety of coffee pods and cups.

17. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

HK$792

HK$912 total

includes taxes & fees

26 Sept - 27 Sept

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A sign instructing to clean up after dogs and dispose of waste, with a Poopy Pouch attached.

A hotel room with a large round table, two sofas, a TV, and a bed.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

18. Candlewood Suites Rochester Mayo Clinic Area by IHG

Rochester

Sean

HK$910

HK$1,048 total

includes taxes & fees

25 Sept - 26 Sept

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Carrie

HK$846

HK$974 total

includes taxes & fees

14 Oct - 15 Oct

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

A hotel reception desk with a modern design, a clock, and a digital screen.

A modern conference room with a long table, multiple chairs, and a wooden partition.

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park

Jackie

HK$855

HK$984 total

includes taxes & fees

25 Sept - 26 Sept

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Stay near popular Wykoff attractions

Ed's Museum

You can spend time browsing the exhibits at Ed's Museum during your travels in Wykoff. Discover the countryside while you're in the area.

See properties

Top Wykoff Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Easy shuttle access to Mayo, At. Mary's appointments"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Excelente muy bien ubicado"

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent

"They were very accommodating when my Mayo Clinic appointments were done early."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We enjoyed our stay. The breakfast was wonderful. We were disappointed the hot tub only ran for the first evening though and was down for maintenance after. And the exercise room was a bit grimy"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Enjoyed my stay Will return"

Brentwood Inn & Suites

8/10 Good

"Easy shuttle service to Mayo Clinic."

Hampton Inn Rochester-South

10/10 Excellent

"Clean room and hotel. Breakfast was great"

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent

"The hotel was clean and quiet. We were happy also to have a shuttle to the Mayo Clinic"

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Was there for a surgery at the Mayo and they were so helpful and accommodating. Very grateful for the facility and the staff"

More cheap stays in Wykoff

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

HK$455

HK$524 total

4 Oct - 5 Oct

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

HK$560

HK$645 total

24 Sept - 25 Sept

includes taxes & fees

7.8/10 Good! (1,023 reviews)

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

HK$644

HK$742 total

22 Oct - 23 Oct

includes taxes & fees

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

HK$735

HK$847 total

26 Sept - 27 Sept

includes taxes & fees

8.8/10 Excellent! (1,001 reviews)

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

HK$738

HK$849 total

26 Sept - 27 Sept

includes taxes & fees

8.2/10 Very good! (1,008 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

HK$753

HK$867 total

18 Oct - 19 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in Wykoff?

Located 22.4 mi (36.1 km) from the heart of Wykoff, AmericInn by Wyndham Rochester Near Mayo Clinic is a top choice for your stay, based on our traveller data. Two other choices for your trip to the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in Wykoff.

What are some of the best holiday rentals that Wykoff has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of Wykoff offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in Wykoff.

If I need to cancel my hotel reservation in Wykoff, will I receive a refund?

Yes! You'll find that most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Wykoff.

How is it staying in Wykoff?

Visitors can enjoy all that Wykoff has to offer, including its museums. There are 322 hotels and other accommodation options in the surrounding area. Find out more about Wykoff.

What should I see while I'm in Wykoff?

A favourite place to visit is Ed's Museum. You'll also find Forestville Mystery Cave State Park and Four Daughters Vineyard & Winery in the area. Take a look at what more there is to see and do in Expedia's Wykoff guide.

What's the weather like in Wykoff?

The hottest months are usually July and August, with an average temperature of 20°C, while the coldest months are January and February, with an average of -5°C. The snowiest months in Wykoff are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

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Wykoff hotels from HK$491

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Wykoff

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Wykoff hotels

1. Americas Best Value Inn & Suites Spring Valley

2. Comfort Inn & Suites Rochester South Mayo Clinic

3. America's Stay Inn Stewartville

4. Spark by Hilton Rochester South

5. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

6. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

7. Holiday Inn Express Rochester South - Mayo Area by IHG

8. Green Gables Inn

9. Stone Mill Hotel & Suites

10. Hampton Inn Rochester-South

11. Country Lodge inn

12. AmericInn by Wyndham Rochester Near Mayo Clinic

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

14. Hyatt House Rochester/Mayo Clinic Area

15. Econo Lodge Mayo Clinic Area

16. Residence Inn by Marriott Rochester Mayo Clinic Area South

17. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

18. Candlewood Suites Rochester Mayo Clinic Area by IHG

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Stay near popular Wykoff attractions

Ed's Museum

Top Wykoff Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Hyatt House Rochester/Mayo Clinic Area

Brentwood Inn & Suites

Hampton Inn Rochester-South

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

More cheap stays in Wykoff

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Brentwood Inn & Suites

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Holiday Inn Express Rochester South - Mayo Area by IHG

Frequently asked questions

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