A tree-lined landscape with a river and fields.

East Prairie hotels from HK$480

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place!"
United States
Jennifer
The price is HK$870
HK$1,001 total
includes taxes & fees
19 Jul - 20 Jul
Drury Inn & Suites Sikeston, MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (586 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is HK$830
HK$939 total
includes taxes & fees
17 Jul - 18 Jul
Hampton Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (474 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is HK$824
HK$932 total
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Sikeston Southwest by IHG

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (97 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is HK$863
HK$977 total
includes taxes & fees
30 Jul - 31 Jul
Fairfield Inn & Suites by Marriott Sikeston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (782 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is HK$445
HK$480 total
includes taxes & fees
5 Jul - 6 Jul
New Orleans Inn Portageville

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,001 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is HK$665
HK$758 total
includes taxes & fees
26 Jul - 27 Jul
Best Western Plus Sikeston I-55

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (66 reviews)
"Clean room, The receptionist very friendly, good parking."
United States
Temera
The price is HK$551
HK$629 total
includes taxes & fees
6 Jul - 7 Jul
Super 8 By Wyndham Marston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (646 reviews)
"Clean rooms,"
United States
Karl
The price is HK$467
HK$518 total
includes taxes & fees
19 Jul - 20 Jul
Super 8 by Wyndham Charleston/Sikeston East MO

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (406 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is HK$699
HK$830 total
includes taxes & fees
12 Jul - 13 Jul
Sleep Inn at Discovery Park of America

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (418 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is HK$588
HK$653 total
includes taxes & fees
5 Jul - 6 Jul
The Riverstone Hotel Charleston-Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (794 reviews)
"I love it there."
United States
Sharika West
The price is HK$608
HK$693 total
includes taxes & fees
5 Jul - 6 Jul
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (187 reviews)
"Friendly staff, comfortable bed."
United States
James
The price is HK$772
HK$916 total
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn Union City

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is HK$973
HK$1,101 total
includes taxes & fees
12 Jul - 13 Jul
TownePlace Suites by Marriott Sikeston

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (573 reviews)
"Good place "
United States
Jade
The price is HK$469
HK$557 total
includes taxes & fees
27 Jul - 28 Jul
Country Hearth Inn & Suites Union City

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (333 reviews)
"I enjoy myself and I will recommend anybody to stay.."
United States
Faye
The price is HK$918
HK$1,090 total
includes taxes & fees
11 Jul - 12 Jul
Holiday Inn Express & Suites Union City by IHG

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (291 reviews)
"The web site said smoking rooms, this is untrue. I was fine with that, but my room smelled like a smoking room. There where cobwebs on the lamps and the tables where dirty. The shower was dirty and had a whole in the ceiling. The outside was very dirty. I would never stay at this hotel aging. I would tell everyone to stay far away from it as they can."
United States
Cyndy
The price is HK$530
HK$589 total
includes taxes & fees
17 Jul - 18 Jul
Quality Inn Cairo I-57

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (298 reviews)
"My main issue was the tub ot had"
United States
Donimique
The price is HK$715
HK$815 total
includes taxes & fees
27 Jul - 28 Jul
Comfort Inn & Suites Sikeston I-55

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (530 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is HK$553
HK$657 total
includes taxes & fees
19 Jul - 20 Jul
Quality Inn Union City US 51

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (656 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
The price is HK$494
HK$563 total
includes taxes & fees
26 Jul - 27 Jul
Super 8 by Wyndham Sikeston/Miner Area

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (140 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is HK$471
HK$561 total
includes taxes & fees
4 Aug - 5 Aug
Country Yard Inn and Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Hotels in East Prairie with star-rating

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

Explore a world of travel with Expedia