O Brien hotels from HK$339

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
5 Jun - 7 Jun
Next weekend
12 Jun - 14 Jun

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,003 reviews)
"Was ok"
United States
James
The price is HK$464
HK$522 total
includes taxes & fees
8 Jun - 9 Jun
Days Inn by Wyndham Lake City I-10
Accessible bathroom

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (721 reviews)
"Loved staying here!! Will definitely visit again!! "
United States
Ashley
The price is HK$559
HK$629 total
includes taxes & fees
14 Jun - 15 Jun
Super 8 by Wyndham Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.6 out of 10, Excellent, (1,115 reviews)
"Enjoyed our stay"
United States
Tammie
The price is HK$754
HK$849 total
includes taxes & fees
29 Jun - 30 Jun
La Quinta Inn & Suite by Wyndham Lake City
Pillow-top beds, desk, laptop workspace, iron/ironing board

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,012 reviews)
"Great stay - easy - accommodating - quiet!"
United States
Paula
The price is HK$867
HK$976 total
includes taxes & fees
5 Jul - 6 Jul
Comfort Suites Lake City
Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (676 reviews)
"Was great!! Clean rooms and peaceful.. Would stay here again and again.."
United States
Anthony
The price is HK$499
HK$549 total
includes taxes & fees
30 Jun - 1 Jul
Quality Inn White Springs Suwanee
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (516 reviews)
"Wonderful place to stay"
United States
Tamela
The price is HK$726
HK$817 total
includes taxes & fees
21 Jun - 22 Jun
Hampton Inn & Suites Alachua I-75
Premium bedding, desk, blackout curtains, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (615 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is HK$509
HK$572 total
includes taxes & fees
7 Jun - 8 Jun
Palms Garden Inn
Exterior

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (223 reviews)
"Amazing spot to be out of the world."
United States
Tati
The price is HK$1,402
HK$2,232 total
includes taxes & fees
16 Jun - 17 Jun
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,006 reviews)
"The staff were amazing, great location, big rooms, great breakfast"
United States
Brittani
The price is HK$783
HK$881 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (192 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is HK$1,163
HK$1,309 total
includes taxes & fees
8 Jun - 9 Jun
The Blanche
BBQ/picnic Area

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,002 reviews)
"We stopped for one night. We have stayed here before when visiting. The staff is always helpful and accommodating ."
United States
William
The price is HK$557
HK$627 total
includes taxes & fees
7 Jun - 8 Jun
Americas Best Value Inn Lake City
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,001 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is HK$495
HK$557 total
includes taxes & fees
8 Jun - 9 Jun
Days Inn by Wyndham Lake City I-75
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (597 reviews)
"older hotel really nicely renovated. Very charmful, comfortable beds. I stayed there because of the reviews and they were accurate. No special amenities' but great value."
United States
William
The price is HK$486
HK$547 total
includes taxes & fees
7 Jun - 8 Jun
Regal Inn
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (262 reviews)
"Great location for this small city."
United States
LaShona
The price is HK$859
HK$966 total
includes taxes & fees
21 Jun - 22 Jun
Courtyard By Marriott Lake City
Snack bar

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,011 reviews)
"Clean helpful staff and breakfast was good.parking good also"
United States
John
The price is HK$854
HK$961 total
includes taxes & fees
7 Jun - 8 Jun
Tru by Hilton Lake City
Lobby sitting area

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (186 reviews)
"GOOD STOP FOR ONE NIGHT IF BREAKING UP TRAVEL TIME."
United States
Victoria LS
The price is HK$517
HK$582 total
includes taxes & fees
7 Jun - 8 Jun
Motel 6 – Lake City, Fl – Medical Center
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,065 reviews)
"Great staff, good room, lovely breakfast"
United States
berendina
The price is HK$789
HK$888 total
includes taxes & fees
7 Jun - 8 Jun
Best Western Plus Lake City
Lobby

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (304 reviews)
"The room was fairly cheap and staff was friendly."
United States
James
The price is HK$573
HK$630 total
includes taxes & fees
21 Jun - 22 Jun
Econo Lodge Live Oak
1 bedroom, laptop workspace, free WiFi, bed sheets

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (18 reviews)
"Calm peaceful stay, staff was very helpful and attentive. "
United States
Patrick
The price is HK$946
HK$1,621 total
includes taxes & fees
7 Jun - 8 Jun
Vista Verde Farm Retreat
Outdoor spa tub

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Pool was clean, so was the room"
United States
Shannon
The price is HK$473
HK$532 total
includes taxes & fees
8 Jun - 9 Jun
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

10/10 Excellent
"My stay was wonderful. I stay an average of 2 a 4 times a month. Always consistently clean and well organized..Same people which speaks volumes about the work place."
Vickie 1-night trip
Posted less than an hour ago
Americas Best Value Inn Lake City

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is HK$473 per night from 8 Jun to 9 Jun
HK$473
HK$532 total
8 Jun - 9 Jun
includes taxes & fees
5/10 (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Comfort Suites Lake City. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Little River Spring Cave divers poolside Hideaway are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia