Serra Mesa hotels in San Diego
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Serra Mesa hotels
1. Hampton Inn San Diego-Kearny Mesa
Hampton Inn San Diego-Kearny Mesa3.5 km from Serra Mesa
9.2 out of 10, Wonderful, (1,006 reviews)
"Great rooms, clean, good experience"
Heather
The price is HK$966
HK$1,109 total
includes taxes & fees
23 Aug - 24 Aug
2. DoubleTree by Hilton Hotel San Diego - Mission Valley
DoubleTree by Hilton Hotel San Diego - Mission Valley4.2 km from Serra Mesa
8.4 out of 10, Very good, (1,745 reviews)
"I will definitely coming to stay there"
Benedict
The price is HK$1,151
HK$1,323 total
includes taxes & fees
9 Aug - 10 Aug
3. Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,077 reviews)
"Very good hotel at the price with good choice of breakfast."
Tirthankar
The price is HK$1,185
HK$1,363 total
includes taxes & fees
3 Aug - 4 Aug
4. Embassy Suites by Hilton San Diego La Jolla
Embassy Suites by Hilton San Diego La JollaUniversity City, 10.3 km from Serra Mesa
8.8 out of 10, Excellent, (1,983 reviews)
"Room was good, breakfast was awesome along with evening drinks."
Jagjit
The price is HK$1,537
HK$1,990 total
includes taxes & fees
16 Aug - 17 Aug
5. Pleasant Inn
Pleasant Inn4.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,491 reviews)
"Would stay again"
Nicolas
The price is HK$723
HK$829 total
includes taxes & fees
13 Aug - 14 Aug
6. Town and Country San Diego
Town and Country San Diego5.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,650 reviews)
"Great experience for a family trip!"
Cynthia
The price is HK$1,406
HK$1,887 total
includes taxes & fees
16 Aug - 17 Aug
7. Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,698 reviews)
"As usual everything about our stay was great."
Edward
The price is HK$1,295
HK$1,489 total
includes taxes & fees
23 Aug - 24 Aug
8. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area6.6 km from Serra Mesa
8.0 out of 10, Very good, (2,840 reviews)
"Staff was friendly and hotel service was great!"
Mike and Maria
The price is HK$1,247
HK$1,433 total
includes taxes & fees
9 Aug - 10 Aug
9. Hilton Garden Inn San Diego Old Town/SeaWorld Area
Hilton Garden Inn San Diego Old Town/SeaWorld AreaOld Town San Diego, 7.4 km from Serra Mesa
8.8 out of 10, Excellent, (1,486 reviews)
"Staff extremely helpful"
LEISA
The price is HK$1,097
HK$1,261 total
includes taxes & fees
23 Aug - 24 Aug
10. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area6.4 km from Serra Mesa
8.8 out of 10, Excellent, (1,660 reviews)
"It was great staying here second time we stay here and we love it"
Jose
The price is HK$1,397
HK$1,606 total
includes taxes & fees
17 Aug - 18 Aug
11. Hampton Inn San Diego/Mission Valley
Hampton Inn San Diego/Mission Valley6.4 km from Serra Mesa
8.6 out of 10, Excellent, (1,659 reviews)
"Great breakfast and access to the city, definitely staying again"
Kerian
The price is HK$1,028
HK$1,182 total
includes taxes & fees
4 Aug - 5 Aug
12. Legacy Resort Hotel & Spa
Legacy Resort Hotel & Spa5.8 km from Serra Mesa
9.2 out of 10, Wonderful, (3,104 reviews)
"Very comfortable, enjoyed my stay!"
Monique
The price is HK$1,546
HK$1,777 total
includes taxes & fees
2 Aug - 3 Aug
13. Sheraton San Diego Resort
Sheraton San Diego Resort10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,593 reviews)
"Great stay"
Karen
The price is HK$1,560
HK$2,190 total
includes taxes & fees
2 Aug - 3 Aug
14. California Suites Hotel
California Suites Hotel4.8 km from Serra Mesa
7.8 out of 10, Good, (2,758 reviews)
"Rooms are well kept and the staff is really friendly"
Michael J
The price is HK$840
HK$964 total
includes taxes & fees
23 Aug - 24 Aug
15. Best Western Seven Seas
Best Western Seven Seas5.3 km from Serra Mesa
8.0 out of 10, Very good, (3,712 reviews)
"Nice place for the price"
Timothy Wayne
The price is HK$910
HK$1,046 total
includes taxes & fees
17 Aug - 18 Aug
16. Handlery Hotel
Handlery Hotel5.7 km from Serra Mesa
8.4 out of 10, Very good, (2,749 reviews)
"Perfect location and very nice and quiet. Will stay here my next trip to San Diego."
Lorenzo
The price is HK$1,051
HK$1,209 total
includes taxes & fees
23 Aug - 24 Aug
17. Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG6.4 km from Serra Mesa
8.4 out of 10, Very good, (1,092 reviews)
"Really nice hotel "
sue
The price is HK$981
HK$1,130 total
includes taxes & fees
12 Aug - 13 Aug
18. Kings Inn San Diego
Kings Inn San Diego6 km from Serra Mesa
8.8 out of 10, Excellent, (3,731 reviews)
"Clean property, nice staff, good food at the Waffle Spot, and we liked the pool and hot tub!👌"
James
The price is HK$912
HK$1,047 total
includes taxes & fees
23 Aug - 24 Aug
19. Best Western Plus Hacienda Hotel Old Town
Best Western Plus Hacienda Hotel Old TownOld Town San Diego, 7.6 km from Serra Mesa
8.4 out of 10, Very good, (2,074 reviews)
"The included breakfast buffet was a great perk and the staff were very friendly."
Allan
The price is HK$1,097
HK$1,261 total
includes taxes & fees
29 Jul - 30 Jul
20. GreenTree Inn San Diego Mission Bay
GreenTree Inn San Diego Mission BayPacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,262 reviews)
"This place is a great value for the price. The breakfast was delicious, and the staff was incredibly friendly and welcoming."
Aericka
The price is HK$883
HK$1,015 total
includes taxes & fees
23 Aug - 24 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Serra Mesa
Find the best Serra Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
