Search Vacation Homes in Seneca

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
15 May - 17 May
In two months
26 Jun - 28 Jun
In three months
24 Jul - 26 Jul
In four months
21 Aug - 23 Aug

Our top choices for Seneca holiday homes

Private kitchen

bedroom available in my house in lovely Seneca. 5 miles from Clemson University

bedroom available in my house in lovely Seneca. 5 miles from Clemson University
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Great location, Charles goes above and beyond to make you feel welcome!"
United States
Monika
bedroom available in my house in lovely Seneca. 5 miles from Clemson University
Property grounds

Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
10.0 out of 10, Exceptional, (9 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
The price is HK$1,920
HK$4,137 total
includes taxes & fees
30 Apr - 1 May
Waterfront 3br home on Lake Hartwell near Clemson
Smart TV, fireplace, books

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (18 reviews)
"Great home base for a Clemson game. "
United States
Karen A.
The price is HK$1,218
HK$2,614 total
includes taxes & fees
12 May - 13 May
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Fridge, microwave, oven, stovetop

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.6 out of 10, Exceptional, (9 reviews)
"Great place with a lot close by"
United States
Aldor D.
The price is HK$1,763
HK$2,810 total
includes taxes & fees
30 Apr - 1 May
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Property grounds

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Serenity Bay
9.8 out of 10, Exceptional, (130 reviews)
"Beautiful home, well furnished, very clean, easy TV"
United States
Alan
The price is HK$3,134
HK$5,861 total
includes taxes & fees
3 May - 4 May
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Smart TV

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
7.8 out of 10, Good, (6 reviews)
"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "
United States
Alisa W.
The price is HK$1,286
HK$2,285 total
includes taxes & fees
4 May - 5 May
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Property grounds

Close to Mountains, Clemson, Asheville, Marina & Best Lake in the Carolinas

Close to Mountains, Clemson, Asheville, Marina & Best Lake in the Carolinas
Seneca
9.0 out of 10, Wonderful, (63 reviews)
"Great location well stocked kitchen ,kayak paddle board pink pong fuse ball"
United States
Walter B.
Close to Mountains, Clemson, Asheville, Marina & Best Lake in the Carolinas
Microwave, oven, stovetop, dishwasher

The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "
United States
Gennifer Q.
The price is HK$1,947
HK$4,357 total
includes taxes & fees
30 Apr - 1 May
The Big Golf House- 10 miles to Clemson
Interior

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.4 out of 10, Exceptional, (9 reviews)
"Very accommodating host. Property is a great location and very clean. "
United States
Craig F.
The price is HK$2,557
HK$5,445 total
includes taxes & fees
4 May - 5 May
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
4 bedrooms, desk, iron/ironing board, WiFi

Johnsons Cove - Lakefront Retreat With EV Charger

Johnsons Cove - Lakefront Retreat With EV Charger
Seneca
10.0 out of 10, Exceptional, (1 review)
"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."
United States
Rebecca G.
The price is HK$2,586
HK$5,929 total
includes taxes & fees
21 May - 22 May
Johnsons Cove - Lakefront Retreat With EV Charger
Smart TV, books, offices

2BR Home w/ Private Baths | Pets | Anderson SC

2BR Home w/ Private Baths | Pets | Anderson SC
Anderson
The price is HK$999
HK$2,490 total
includes taxes & fees
4 May - 5 May
2BR Home w/ Private Baths | Pets | Anderson SC
Living area

Downtown Easley Home

Downtown Easley Home
Easley
8.0 out of 10, Very good, (7 reviews)
"Comfortable beds, nice linens. Well stocked kitchen. Very clean!"
United States
Maura B.
The price is HK$698
HK$1,845 total
includes taxes & fees
11 May - 12 May
Downtown Easley Home
Terrace/patio

Welcome To Downtown Pickens close to Clemson and Lake Keowee

Welcome To Downtown Pickens close to Clemson and Lake Keowee
Pickens
9.8 out of 10, Exceptional, (33 reviews)
"Great location, close to great restaurants and downtown. Beautiful area!"
United States
Tom B.
The price is HK$846
HK$2,061 total
includes taxes & fees
4 May - 5 May
Welcome To Downtown Pickens close to Clemson and Lake Keowee
Smart TV, fireplace

Lakefront Home on Lake Hartwell, private covered dock, ~16 miles from Clemson

Lakefront Home on Lake Hartwell, private covered dock, ~16 miles from Clemson
Anderson
10.0 out of 10, Exceptional, (63 reviews)
"exceptional across the board! the location was ideal, host was attentive and very thoughtful. would highly recommend."
United States
Jonathan S.
The price is HK$1,411
HK$4,524 total
includes taxes & fees
30 Apr - 1 May
Lakefront Home on Lake Hartwell, private covered dock, ~16 miles from Clemson
Fridge, microwave, oven, stovetop

Sunny Side Cottage: Cozy Stay by Anderson U!

Sunny Side Cottage: Cozy Stay by Anderson U!
Anderson
9.8 out of 10, Exceptional, (24 reviews)
"The accommodations were adequate and the location was excellent."
United States
Pat
The price is HK$1,334
HK$3,743 total
includes taxes & fees
11 May - 12 May
Sunny Side Cottage: Cozy Stay by Anderson U!
Exterior

Lake front with dock & covered slip on Lake Hartwell. The Reese Retreat!

Lake front with dock & covered slip on Lake Hartwell. The Reese Retreat!
Westminster
8.6 out of 10, Excellent, (8 reviews)
"Awesome lake house. Hope to stay again in the future at some point!"
United States
steven r.
The price is HK$987
HK$2,724 total
includes taxes & fees
3 May - 4 May
Lake front with dock & covered slip on Lake Hartwell. The Reese Retreat!
On the beach, sun-loungers, beach towels

Clemson|LakeAccess|ParkPass|PizzaOven|YouTubeTV|King|SUPs|EV

Clemson|LakeAccess|ParkPass|PizzaOven|YouTubeTV|King|SUPs|EV
Anderson
10.0 out of 10, Exceptional, (9 reviews)
"Stefania was more than helpful! We will definitely book with her again! "
United States
Anna S.
The price is HK$1,340
HK$4,402 total
includes taxes & fees
30 Apr - 1 May
Clemson|LakeAccess|ParkPass|PizzaOven|YouTubeTV|King|SUPs|EV
Property grounds

Spacious 5-BR House with Long Range Views of Mtns. & Lake Jocassee,Near Brevard!

Spacious 5-BR House with Long Range Views of Mtns. & Lake Jocassee,Near Brevard!
Brevard
10.0 out of 10, Exceptional, (5 reviews)
"We enjoyed our stay here very much. If you’re looking for a rustic cabin to unplug and enjoy top notch views, this is the place for you. It is a bit remote which was a positive for us but keep that in mind if you book. We grilled out in the evenings and enjoyed spending time with our family. "
United States
Monica
The price is HK$1,943
HK$4,440 total
includes taxes & fees
13 May - 14 May
Spacious 5-BR House with Long Range Views of Mtns. & Lake Jocassee,Near Brevard!
Outdoor dining

The Rustic Rectangle

The Rustic Rectangle
Pendleton
10.0 out of 10, Exceptional, (10 reviews)
"Cozy, clean and quiet! Loved that we could have our dogs stay with us! "
United States
Jennifer T.
The price is HK$882
HK$2,040 total
includes taxes & fees
4 May - 5 May
The Rustic Rectangle
Terrace/patio

Luxury-Family Friendly-Game Room-Huge Porch-Comfortable/Beautiful Beds

Luxury-Family Friendly-Game Room-Huge Porch-Comfortable/Beautiful Beds
Highlands
10.0 out of 10, Exceptional, (17 reviews)
"An excellent vacation property."
United States
Kathy
The price is HK$1,142
HK$4,238 total
includes taxes & fees
4 May - 5 May
Luxury-Family Friendly-Game Room-Huge Porch-Comfortable/Beautiful Beds
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Seneca Hotel Reviews

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

10/10 Excellent
"The morning manager was the best."
Howarth 2-night trip
Posted 1 day ago
Days Inn by Wyndham Seneca / Clemson Area

Find out more about Seneca

Seneca Vacation Homes information

Number of reviews
354
Accommodation
657 Vacation Homes
Lowest Price
HK$1,845
Highest Price
HK$5,929

Explore a world of travel with Expedia