Seneca Vacation Homes

An overlooking view in Seneca, South Carolina

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

In two weeks

In two months

In three months

In four months

Our top choices for Seneca holiday homes

Holiday Home in Seneca

Mandy H.

HK$3,088 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Seneca

Alisa W.

HK$2,264 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Seneca

Aldor D.

HK$2,599 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Seneca

Gennifer Q.

HK$4,215 total

includes taxes & fees

18 Jan - 19 Jan

4 bedrooms, desk, iron/ironing board, WiFi

Holiday Home in Seneca

"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."

Rebecca G.

HK$6,197 total

includes taxes & fees

20 Jan - 21 Jan

Holiday Home in Seneca

"Main floor was clean but basement and loft, cleaners missed a lot. It was very dusty with lots of cobwebs. Cleaners have missed a lot of places over and over again. The downstairs deck was full of pollen and so dirty we couldn’t sit out there. Wish there was an umbrella on top deck- no shade or cover when rains. Wish there was somewhere to put suitcases but w no closet space and no dresser tops, suitcases were all over floors. Was just hoping for a cleaner space for what we paid. Overall it was...

Kristen F.

HK$4,146 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Seneca

Benjamin J.

HK$5,418 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Serenity Bay

stacy s.

HK$4,854 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Pickens

Tom B.

HK$1,999 total

includes taxes & fees

20 Jan - 21 Jan

Holiday Home in Pickens

Kat C.

HK$1,299 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Easley

tracy

HK$2,419 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Easley

Kathy M.

HK$2,329 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Toccoa

HK$886 total

includes taxes & fees

29 Jan - 30 Jan

Holiday Home in Anderson

Kevin K.

HK$2,812 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Easley

"This is a beautiful place to stay in, large rooms loved the open kitchen adjoining the living area. Me and my husband and my daughter and son in law stayed here for a weekend. We were in town for my granddaughters Volleyball games, and we were an easy 7 min drive from the event venue. We had lunch across the street from the townhouse at the Silos and later that evening went back for live music. We would stary again and Dane was a great host! Only word of advice is if you cannot do stairs this is...

Brenda W.

HK$2,329 total

includes taxes & fees

20 Jan - 21 Jan

Holiday Home in Pendleton

Jennifer T.

HK$1,809 total

includes taxes & fees

26 Jan - 27 Jan

Holiday Home in Pickens

Jeromy S.

HK$1,843 total

includes taxes & fees

19 Jan - 20 Jan

Holiday Home in Anderson

Slava M.

HK$3,614 total

includes taxes & fees

18 Jan - 19 Jan

Holiday Home in Easley

CANDY B.

HK$2,026 total

includes taxes & fees

30 Jan - 31 Jan

Holiday Home in Highlands

Dena H.

HK$4,330 total

includes taxes & fees

10 Feb - 11 Feb

View all properties

Find holiday rentals that suit your style

Cabins

Apartments

Save an average of 15% on thousands of hotels when you're signed in

Top Seneca Hotel Reviews

Lakeside Lodge Clemson

10/10 Excellent

"The staff was very friendly and the Lodge and rooms were very clean and spacious. Restaurant on site was really good and the Fireplace in the lobby was great. "

Days Inn by Wyndham Anderson

10/10 Excellent

"We stayed at this hotel over the weekend to celebrate our anniversary, and it turned into one of the best hotel experiences we’ve ever had. My fiancée and I were looking for something special, and Jennifer suggested their decorated room for occasions like this. I trusted her recommendation, and I’m so glad I did. The moment we walked into the room, we were honestly amazed. It was beautifully decorated from top to bottom. The bed setup was perfect, the details were thoughtful, and the atmosphere felt romantic and relaxing. The jacuzzi tub inside the bedroom was the highlight. It made the whole experience feel extra special. We truly enjoyed every moment of our stay and created memories we’ll always remember. I would highly recommend this hotel to anyone celebrating a special occasion."

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent

"Check-in was fast and efficient. Our room was clean and spacious. Temperature control was great. Beds were comfy. The breakfast each morning was great, providing sources of protein and fruits as well as the typical continental selections, but they actually had a vat of grits that were just about the right thickness and consistency - just what a Southern boy needs!"

Find out more about Seneca