Sikeston hotels from HK$448

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
10 May - 11 May
Tomorrow
11 May - 12 May
Next weekend
15 May - 17 May
In two weeks
22 May - 24 May

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sikeston hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,014 reviews)
"Nice place to stay"
United States
Lance
The price is HK$877
HK$1,008 total
includes taxes & fees
24 May - 25 May
Drury Inn & Suites Sikeston, MO
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,007 reviews)
"Room was very clean. Breakfast was good with several options. Would recommend staying here."
United States
Linda
The price is HK$822
HK$927 total
includes taxes & fees
17 May - 18 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,009 reviews)
"Clean room and wonderful staff. Great amenities "
United States
Myesha
The price is HK$783
HK$883 total
includes taxes & fees
25 May - 26 May
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (506 reviews)
"Great place! "
United States
Michelle
The price is HK$1,015
HK$1,150 total
includes taxes & fees
30 May - 31 May
Courtyard by Marriott Cape Girardeau Downtown
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (557 reviews)
"Perfect nights stay!! "
United States
Amanda
The price is HK$893
HK$1,011 total
includes taxes & fees
17 May - 18 May
Hampton Inn Sikeston
Free daily buffet breakfast

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,007 reviews)
"Clean room, friendly staff, great breakfast. "
United States
jessica
The price is HK$736
HK$830 total
includes taxes & fees
25 May - 26 May
Drury Inn & Suites Cape Girardeau
Lobby

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (180 reviews)
"Nice room, good breakfast "
United States
KENNETH
The price is HK$725
HK$818 total
includes taxes & fees
7 Jun - 8 Jun
Fairfield Inn & Suites by Marriott Cape Girardeau
Exterior

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (762 reviews)
"Property was easily accessible and very clean!!"
United States
Denise
The price is HK$768
HK$831 total
includes taxes & fees
11 May - 12 May
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Desk, laptop workspace, blackout curtains, free cots/infant beds

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,008 reviews)
"Would stay again when in the area."
United States
Jack
The price is HK$564
HK$636 total
includes taxes & fees
24 May - 25 May
Pear Tree Inn Cape Girardeau West
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,004 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is HK$728
HK$830 total
includes taxes & fees
20 May - 21 May
Best Western Plus Sikeston I-55
Lobby

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,007 reviews)
"Clean room, friendly staff, good breakfast and dinner variety,large open parking, clean pool and exercise room. All around great stay. "
United States
Jeremy
The price is HK$673
HK$712 total
includes taxes & fees
7 Jun - 8 Jun
Drury Inn & Suites Jackson MO
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (462 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is HK$822
HK$931 total
includes taxes & fees
7 Jun - 8 Jun
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lobby sitting area

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (566 reviews)
"I ALWAYS stay here when I come to Cape! Wonderful, great place!"
United States
Audra
The price is HK$922
HK$1,040 total
includes taxes & fees
11 May - 12 May
The Riverview
Snack bar

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (125 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
The price is HK$764
HK$870 total
includes taxes & fees
24 May - 25 May
Tru By Hilton Cape Girardeau
Lobby

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (812 reviews)
"We enjoyed our stay"
United States
Wanda
The price is HK$828
HK$934 total
includes taxes & fees
24 May - 25 May
Hampton Inn Cape Girardeau I 55 East
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (16 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is HK$994
HK$1,126 total
includes taxes & fees
24 May - 25 May
TownePlace Suites by Marriott Sikeston
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (75 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is HK$861
HK$975 total
includes taxes & fees
7 Jun - 8 Jun
Fairfield Inn & Suites by Marriott Sikeston
Lobby

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (20 reviews)
"We love staying at this inn. It truly feels like we’re in a friend’s beautifully appointed home. We’ll be back here again for certain. "
United States
Elsa
The price is HK$1,071
HK$1,208 total
includes taxes & fees
14 May - 15 May
Rockwood Inn
Lobby

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very good, (765 reviews)
"Beds felt amazing. My family and I had a great time"
United States
Gary
The price is HK$721
HK$781 total
includes taxes & fees
17 May - 18 May
Comfort Suites Jackson-Cape Girardeau
Lobby

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (739 reviews)
"It was good, but a noticeable hole in the wall above the toilet paper."
United States
Martin
The price is HK$521
HK$588 total
includes taxes & fees
24 May - 25 May
Quality Inn Cape Girardeau North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Sikeston attractions

Sikeston Depot Museum

3.8/5 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston
Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri

Top Sikeston Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"I loved everything. Was surprised of the amenities that they offered that evening drinks and food. For FREE"
John 2-night trip
Posted 2 hours ago
Drury Inn & Suites Sikeston, MO

More cheap stays in Sikeston

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
The price is HK$493 per night from 12 May to 13 May
HK$493
HK$562 total
12 May - 13 May
includes taxes & fees
6.8/10 (623 reviews)

Hotels in Sikeston with star-rating

Frequently asked questions

Where is the best place to stay in Sikeston?
Based on our traveller data, Drury Inn & Suites Sikeston, MO is one of the top choices for your stay. This hotel offers free breakfast and an outdoor pool. Other good choices for your stay include Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in Sikeston.
What are some of the best holiday rentals that Sikeston has to offer?
Beautiful location in the secluded woods: This holiday home rental outside of Sikeston offers a fireplace, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in Sikeston.
If I need to cancel my hotel reservation in Sikeston, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.
What's the best budget-friendly hotel in Sikeston?
Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Sikeston.
What's the best family accommodation in Sikeston?
Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Find more child-friendly accommodations in Sikeston.
What's the best LGBTQ-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Hampton Inn Sikeston are two other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Sikeston.
What's the best dog-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top hotel for people travelling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good choices for you and your pet's trip include Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See more pet-friendly hotel accommodations in Sikeston.
What are some hotels with pools in Sikeston?
Best Western Plus Sikeston I-55 is a top hotel with a pool, free full breakfast and free self-parking. TownePlace Suites by Marriott Sikeston is another choice with an on-site pool. View all hotels with pools in Sikeston.
What is staying in Sikeston like?
Families will find child-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 14 hotels and other accommodation options to choose from. Find out more about Sikeston.
What is there to see in Sikeston?
A couple of favourite places to visit are Sikeston Depot Museum and Central Park. You'll also find River Ridge Winery and Front Street Studio & Art Gallery in the area. Take a look at what more there is to see and do in Expedia's Sikeston guide.
What's the seasonal weather in Sikeston?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Sikeston is 1536 mm.

Explore a world of travel with Expedia