Best Sikeston Hotels in 2026 from HK$518 - Fully Refundable Options

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Our top choices for Sikeston hotels

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

1. Hampton Inn Sikeston

Sikeston

Deborah

HK$902 total

includes taxes & fees

19 Nov - 20 Nov

A buffet with various food items, including omelets and baked goods, served in metal containers.

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Wesley

HK$848 total

includes taxes & fees

13 Dec - 14 Dec

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

3. Drury Inn & Suites Sikeston, MO

Sikeston

Tiffany

HK$848 total

includes taxes & fees

29 Nov - 30 Nov

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

4. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

HK$981 total

includes taxes & fees

19 Nov - 20 Nov

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

5. Best Western Plus Sikeston I-55

Sikeston

Shelley

HK$650 total

includes taxes & fees

7 Dec - 8 Dec

6. TownePlace Suites by Marriott Sikeston

Sikeston

Mark

HK$972 total

includes taxes & fees

19 Nov - 20 Nov

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

7. Days Inn and Suites by Wyndham Sikeston

Sikeston

Earl

HK$593 total

includes taxes & fees

17 Nov - 18 Nov

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

8. Comfort Inn & Suites Sikeston I-55

Sikeston

Fred

HK$752 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

HK$621 total

includes taxes & fees

17 Nov - 18 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

10. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

HK$518 total

includes taxes & fees

19 Nov - 20 Nov

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

11. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Melody

HK$885 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

12. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Rebecca

HK$848 total

includes taxes & fees

11 Dec - 12 Dec

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

13. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Mary

HK$796 total

includes taxes & fees

25 Nov - 26 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

14. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Dane

HK$895 total

includes taxes & fees

26 Nov - 27 Nov

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

15. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

richard

HK$678 total

includes taxes & fees

15 Nov - 16 Nov

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

16. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Britney

HK$864 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

17. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Livia

HK$637 total

includes taxes & fees

16 Nov - 17 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

18. Country Yard Inn and Suite

Sikeston

Marianne

HK$545 total

includes taxes & fees

13 Nov - 14 Nov

Two front-loading washing machines in a laundry room with a white wall and a sign indicating cycle times.

19. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kelly

HK$1,032 total

includes taxes & fees

29 Nov - 30 Nov

A modern retail area with a display of local items and snacks.

20. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

HK$761 total

includes taxes & fees

29 Nov - 30 Nov

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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)

Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.

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Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston

A tree with sunlight filtering through its leaves, creating a warm glow.

Top Sikeston Hotel Reviews

Hampton Inn Sikeston

10/10 Excellent

"We really enjoyed the Dog Park as we were traveling with our dogs. The outdoor fire pit was great to sit at on the cool evenings. Breakfast had a variety of options from hot to cold food and diy waffles."

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"I didn't get the receptionist's name, but she was absolutely wonderful! As we were leaving today after our 2-night stay, she asked if we needed ice for our cooler, and then proceeded to fill our cooler with ice and carried it out to our vehicle. So very, very kind, and very much appreciated."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

8/10 Good

"The room was clean and fresh. But I couldn’t say that about the breakfast area. The food was cold, no coffee, the juice machine was gross, the floor was wet and sticky. Kept running out of food. The trash area stunk around the food. Also the elevator floors were always wet and sticky as well."

More cheap stays in Sikeston

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

HK$455

HK$518 total

19 Nov - 20 Nov

includes taxes & fees

Hotels in Sikeston with star-rating

Frequently asked questions

Where is the best place to stay in Sikeston?

Based on our traveller data, Drury Inn & Suites Sikeston, MO is one of the top choices for your stay. This hotel offers free breakfast and an outdoor pool. Other good choices for your stay include Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in Sikeston.

What are some of the best holiday rentals that Sikeston has to offer?

On the Wine Trail Hot Tub Wi-Fi : This holiday home rental outside of Sikeston is located on a lake, and has a patio, 1 hot tub and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in Sikeston.

If I need to cancel my hotel reservation in Sikeston, will I receive a refund?

Yes, you'll find most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.

What's the best budget-friendly hotel in Sikeston?

Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Sikeston.

What's the best family accommodation in Sikeston?

Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Find more child-friendly accommodations in Sikeston.

What's the best LGBTQ-friendly hotel in Sikeston?

Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest by IHG are two other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Sikeston.

What's the best dog-friendly hotel in Sikeston?

Drury Inn & Suites Sikeston, MO is a top hotel for people travelling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good choices for you and your pet's trip include Best Western Plus Sikeston I-55 and Days Inn and Suites by Wyndham Sikeston. See more pet-friendly hotel accommodations in Sikeston.

What are some hotels with pools in Sikeston?

Best Western Plus Sikeston I-55 is a top hotel with a pool, free full breakfast and free self-parking. TownePlace Suites by Marriott Sikeston is another choice with an on-site pool. View all hotels with pools in Sikeston.

What is staying in Sikeston like?

Families will find child-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 16 hotels and other accommodation options to choose from. Find out more about Sikeston.

What is there to see in Sikeston?

A couple of favourite places to visit are Sikeston Depot Museum and Central Park. You'll also find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery in the area. Take a look at what more there is to see and do in Expedia's Sikeston guide.

What's the seasonal weather in Sikeston?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Sikeston is 1536 mm.

Sikeston hotels from HK$518

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Our top choices for Sikeston hotels

1. Hampton Inn Sikeston

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

3. Drury Inn & Suites Sikeston, MO

4. Fairfield Inn & Suites by Marriott Sikeston

5. Best Western Plus Sikeston I-55

6. TownePlace Suites by Marriott Sikeston

7. Days Inn and Suites by Wyndham Sikeston

8. Comfort Inn & Suites Sikeston I-55

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. Super 8 by Wyndham Sikeston/Miner Area

11. Drury Plaza Hotel Cape Girardeau Conference Center

12. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

13. Drury Inn & Suites Cape Girardeau

14. Fairfield Inn & Suites by Marriott Cape Girardeau

15. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

16. Hampton Inn Cape Girardeau I 55 East

17. Pear Tree Inn Cape Girardeau West

18. Country Yard Inn and Suite

19. Courtyard by Marriott Cape Girardeau Downtown

20. Tru By Hilton Cape Girardeau

Stay near popular Sikeston attractions

Sikeston Depot Museum

Sikeston and related destinations

Top Sikeston Hotel Reviews

Hampton Inn Sikeston

More cheap stays in Sikeston

Super 8 by Wyndham Sikeston/Miner Area

Hotels in Sikeston with star-rating

Frequently asked questions

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