Best Sikeston Hotels in 2026 from HK$511 - Fully Refundable Options

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Our top choices for Sikeston hotels

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

HK$839

HK$965 total

includes taxes & fees

29 Sept - 30 Sept

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

2. Hampton Inn Sikeston

Sikeston

John

HK$797

HK$903 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

michael

HK$745

HK$844 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

4. Best Western Plus Sikeston I-55

Sikeston

Shelley

HK$684

HK$779 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

HK$792

HK$897 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

HK$784

HK$885 total

includes taxes & fees

28 Sept - 29 Sept

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

7. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

William

HK$448

HK$511 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

8. TownePlace Suites by Marriott Sikeston

Sikeston

Stacy

HK$784

HK$888 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious lobby with a central atrium, a piano, and a reception desk.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

9. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

HK$520

HK$593 total

includes taxes & fees

27 Sept - 28 Sept

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

An outdoor patio with tables and chairs, a stone wall, and large windows.

10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

HK$660

HK$714 total

includes taxes & fees

28 Sept - 29 Sept

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

11. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

HK$706

HK$796 total

includes taxes & fees

9 Oct - 10 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

12. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

HK$545

HK$621 total

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

13. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

HK$792

HK$902 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

14. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

HK$565

HK$637 total

includes taxes & fees

28 Sept - 29 Sept

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

15. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

HK$830

HK$936 total

includes taxes & fees

4 Oct - 5 Oct

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

16. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

HK$701

HK$799 total

includes taxes & fees

20 Oct - 21 Oct

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A lobby with seating areas, a reception desk, and a bar.

17. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

HK$1,016

HK$1,152 total

includes taxes & fees

4 Oct - 5 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

18. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

HK$793

HK$895 total

includes taxes & fees

1 Oct - 2 Oct

A modern retail area with a display of local items and snacks.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

19. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

HK$701

HK$798 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

20. The Riverview

Cape Girardeau

Alyssa

HK$896

HK$1,011 total

includes taxes & fees

4 Oct - 5 Oct

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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)

Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.

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City of Miner Convention Center

This versatile 16,000-square-foot venue in Miner, Missouri hosts conferences, weddings, and community gatherings. Modern meeting rooms and a commercial kitchen make it ideal for various events.

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Central Park

7.2/10 (56 reviews)

Central Park offers a peaceful retreat with playgrounds and open spaces for Sikeston families. Bring a blanket for a relaxing picnic or watch children enjoy the recreational facilities.

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Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston

Top Sikeston Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"The hall ways smelled so good but we did get dirty blankets . They have many restaurants and stores options really closed by so if you have children it is a great spot to stop specifically since is just in the entry or exit of the hwy ."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"."

Hampton Inn Sikeston

10/10 Excellent

"Staff was great"

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

Pear Tree Inn Cape Girardeau West

8/10 Good

"I was looking for something that was good quality and wouldn’t break my wallet. This place was what I was expecting. Lady working the breakfast was extremely polite and helpful."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Huge rooms! Never had a hotel room soo big! Breakfast was great! Walking into a clean hotel and greeting you with a smile! The only thing was the pool was so cold! Everything else was perfect! Great safe location! Beautiful town!"