Photo by Ryan Coleman

Search Vacation Homes in Sikeston

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Beautiful location in the secluded woods

10.0 out of 10, Exceptional, (42)
"Our trip was to attend my son's graduation from SIU. The cabin was in an accessible spot to Carbondale and was great for the 5 of us. We enjoyed our stay!"
The price is HK$777
HK$1,406 total
includes taxes & fees
14 Aug - 15 Aug
Beautiful location in the secluded woods

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
9.8 out of 10, Exceptional, (18)
"Great place to stay. "
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

Sunset Ridge - Cabin 4

10.0 out of 10, Exceptional, (7)
Sunset Ridge - Cabin 4

Notting Hill Cottage

9.6 out of 10, Exceptional, (322)
"Perfect getaway for peace and quiet. Beautiful hikes and great for dogs. Hot tub was excellent. "
Notting Hill Cottage

Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

10.0 out of 10, Exceptional, (21)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

Woodland Retreat - Cabin 3

10.0 out of 10, Exceptional, (3)
"Great location. This place had it all and clean!"
Woodland Retreat - Cabin 3

On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower

9.8 out of 10, Exceptional, (171)
"We wanted a good central location for our time in wine country. This place was perfect…and we were able to check out several Wineries during our stay. "
On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

9.8 out of 10, Exceptional, (154)
"House was clean and comfortable and fun. Would stay again!"
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Private lake, beach & hot tub, romantic getaway or family vaca

9.8 out of 10, Exceptional, (29)
"We had a funeral in Poplar Bluff and needed a place to stay. This worked well for our family for the few days we stayed. "
Private lake, beach & hot tub, romantic getaway or family vaca

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

10.0 out of 10, Exceptional, (97)
"Perfect location, next to trails, wineries. Quiet, cozy, beds were super comfortable, extremley clean, no complaints at all."
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp

9.4 out of 10, Exceptional, (3)
"Our stay was awesome. House was very clean and adorable! "
Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp

Hilltop Retreat, a modernly-rustic getaway!

10.0 out of 10, Exceptional, (39)
"Great place for family visits to SIU."
Hilltop Retreat, a modernly-rustic getaway!

Betty's Vineyard House - On the Shawnee Wine Trail - Walk to/from the Winery!

10.0 out of 10, Exceptional, (80)
"Wonderful place with great amenities. We'll be back!"
Betty's Vineyard House - On the Shawnee Wine Trail - Walk to/from the Winery!

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

10.0 out of 10, Exceptional, (117)
"Second time returning to property and planning a third visit. Beds are very comfortable, house is welcoming and well stocked. Always nice sitting on the porch and watching the deer. Home is private but close to attractions. "
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Cozy Anna Home Near Southern Illinois Attractions!

10.0 out of 10, Exceptional, (9)
"We had a great experience staying here. It was the perfect location! "
Cozy Anna Home Near Southern Illinois Attractions!

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (139)
"The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area."
The price is HK$1,178
HK$1,923 total
includes taxes & fees
11 Aug - 12 Aug
Serenity South -- Gardens, River-Views, and Refreshing Space

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (43)
"Has everything you need. Comfy and in a great location. "
The price is HK$636
HK$793 total
includes taxes & fees
11 Aug - 12 Aug
Little Blue Cottage on Spanish

Pinecrest Haven - Cabin 5

Pinecrest Haven - Cabin 5

Hillside Haven - Cabin 1

10.0 out of 10, Exceptional, (2)
"Great little cabin and perfect for a couple getaway. Everything was close by and loved being able to walk to Feather Hills winery. Thanks for a great stay "
Hillside Haven - Cabin 1

^4BdrmsEACHw/PRIVATEBathrms^

9.8 out of 10, Exceptional, (15)
"We had an amazing time at the house, the host was very thoughtful about everything they had in the house! Perfect getaway! "
^4BdrmsEACHw/PRIVATEBathrms^
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Sikeston Hotel Reviews