Photo by George Zimzores

South Central Houston hotels in Houston

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Central Houston hotels

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is HK$1,669
HK$5,137 total
includes taxes & fees
21 Dec - 22 Dec
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
The Green Haus Luxxe Cabana Rooftop Retreat

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (202)
" Beautiful relaxing love this place best I seen thank you"
United States
James
The price is HK$1,611
HK$2,001 total
includes taxes & fees
21 Dec - 22 Dec
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (542)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is HK$1,240
HK$1,451 total
includes taxes & fees
6 Jan - 7 Jan 2026
La Maison in Midtown an urban B&B

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1005)
"Very clean room very polite staff"
United States
David
The price is HK$1,078
HK$1,417 total
includes taxes & fees
25 Dec - 26 Dec
InterContinental Houston by IHG

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (888)
"Nice place to stay"
United States
Alexandra
The price is HK$1,142
HK$1,336 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hilton University of Houston

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
7.8 out of 10, Good, (37)
"Check in staff was friendly and room was clean."
United States
Alfredo
The price is HK$606
HK$710 total
includes taxes & fees
29 Dec - 30 Dec
Downtowner Inns - Houston Downtown

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (58)
"Great location will stay again "
United States
Jason
The price is HK$744
HK$871 total
includes taxes & fees
25 Dec - 26 Dec
Wanderstay Boutique Hotel

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1022)
"Excellent breakfast and bar"
United States
Misty
The price is HK$1,006
HK$1,252 total
includes taxes & fees
25 Dec - 26 Dec
The Westin Houston Medical Center/Museum District

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (478)
"Solid hotel and amenities"
United States
Kenneth
The price is HK$865
HK$1,012 total
includes taxes & fees
25 Dec - 26 Dec
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1001)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is HK$1,052
HK$1,477 total
includes taxes & fees
2 Jan - 3 Jan 2026
Houston Marriott Medical Center/Museum District

Houston 6 Bedroom Home

Houston 6 Bedroom Home
2.0 star property
South Central Houston
The price is HK$3,880
HK$4,540 total
includes taxes & fees
22 Dec - 23 Dec
Houston 6 Bedroom Home

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1857)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (226)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is HK$420
HK$492 total
includes taxes & fees
21 Dec - 22 Dec
Southmore Boulevard Motel

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1001)
"Nice hotel"
United States
Robert Jeanmard
The price is HK$646
HK$756 total
includes taxes & fees
21 Dec - 22 Dec
Americas Best Value Inn Medical Center Downtown

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1773)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is HK$669
HK$792 total
includes taxes & fees
25 Dec - 26 Dec
Hilton Houston Plaza/Medical Center

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1002)
"Room was very large…"
United States
Veronica
The price is HK$483
HK$568 total
includes taxes & fees
21 Dec - 22 Dec
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.4 out of 10, Very good, (188)
"This is an amazing place to stay."
United States
Darius
The price is HK$447
HK$523 total
includes taxes & fees
1 Jan - 2 Jan 2026
Wanderstay Houston Hostel

The Oasis Checkmate HTX Rooftop

The Oasis Checkmate HTX Rooftop
3.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2)
"This place is amazing! Beautiful decor and location is perfect for any event near the convention center. Safe and secure. Hosts were responsive and friendly. I let them know the ironing board was missing and they had a new one sent from Amazon the next day! 10/10 recommend and will rebook. "
United States
Veronica
The Oasis Checkmate HTX Rooftop

Posh Dtwn Midtown Home w Stunning Roof-topterrace

Posh Dtwn Midtown Home w Stunning Roof-topterrace
3.0 star property
South Central Houston
Posh Dtwn Midtown Home w Stunning Roof-topterrace
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Houston Heights

You'll enjoy the coffee shops and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Continental Club and Midtown Arts and Theater Center Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 4-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other top choices in the neighbourhood include InterContinental Houston by IHG and MyCrib Houston Hostel.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1169 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and James Turrell's Twilight Epiphany Skyscape. Continental Club and Midtown Arts and Theater Center Houston are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station.

Explore a world of travel with Expedia