South Main hotels in Houston
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Our top choices for South Main hotels
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,015 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is HK$733
HK$858 total
includes taxes & fees
17 Jan - 18 Jan
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (829 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is HK$608
HK$711 total
includes taxes & fees
26 Jan - 27 Jan
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Clean rooms, quiet property. We will be back again. "
Javier
The price is HK$617
HK$722 total
includes taxes & fees
27 Jan - 28 Jan
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (996 reviews)
"Easy access to stadium "
Richard
The price is HK$765
HK$895 total
includes taxes & fees
23 Jan - 24 Jan
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,204 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is HK$905
HK$1,059 total
includes taxes & fees
24 Jan - 25 Jan
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport29.9 km from South Main
8.4 out of 10, Very good, (1,010 reviews)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
Debra
The price is HK$655
HK$766 total
includes taxes & fees
30 Jan - 31 Jan
Days Inn & Suites by Wyndham Houston Hobby Airport
Days Inn & Suites by Wyndham Houston Hobby Airport15.8 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Awesome friendly staff and spotless rooms. Kudos to the manager."
Mauricio
The price is HK$577
HK$675 total
includes taxes & fees
21 Jan - 22 Jan
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road22.8 km from South Main
8.4 out of 10, Very good, (1,001 reviews)
"Safe hotel"
Nick
The price is HK$570
HK$667 total
includes taxes & fees
22 Jan - 23 Jan
Homewood Suites By Hilton Houston IAH Airport Beltway 8
Homewood Suites By Hilton Houston IAH Airport Beltway 829.9 km from South Main
8.4 out of 10, Very good, (934 reviews)
"The staff were very helpful and friendly. The rooms were very clean and comfortable. I’d book there again as it’s close to the airport and out of the congestion of the City."
Mlela
The price is HK$633
HK$740 total
includes taxes & fees
21 Jan - 22 Jan
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,015 reviews)
"It was a great stay "
Thrideep
The price is HK$680
HK$799 total
includes taxes & fees
23 Jan - 24 Jan
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very good, (1,300 reviews)
"Very comfortable clean and all around great stay"
Landy
The price is HK$496
HK$581 total
includes taxes & fees
2 Feb - 3 Feb
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.6 out of 10, (1,003 reviews)
"It was ok, to spend a night waiting for a flight. "
Hamlet
The price is HK$421
HK$492 total
includes taxes & fees
24 Jan - 25 Jan
DoubleTree by Hilton Houston Intercontinental Airport
DoubleTree by Hilton Houston Intercontinental Airport31.5 km from South Main
8.4 out of 10, Very good, (1,004 reviews)
"Clean rooms, friendly staff. Yummy warm cookies upon checkin! "
Amanda
The price is HK$1,017
HK$1,189 total
includes taxes & fees
30 Jan - 31 Jan
Hampton Inn & Suites Houston Medical Center NRG Park
Hampton Inn & Suites Houston Medical Center NRG ParkTexas Medical Center, 3 km from South Main
8.2 out of 10, Very good, (1,007 reviews)
"Clean, staff was great. "
Lavetta
The price is HK$793
HK$932 total
includes taxes & fees
23 Jan - 24 Jan
WoodSpring Suites Houston Northwest
WoodSpring Suites Houston Northwest23.8 km from South Main
7.6 out of 10, Good, (516 reviews)
"Great experience!!"
Bryant
The price is HK$475
HK$547 total
includes taxes & fees
25 Jan - 26 Jan
Four Points by Sheraton Houston Hobby Airport
Four Points by Sheraton Houston Hobby AirportSoutheast Houston, 15.3 km from South Main
7.8 out of 10, Good, (1,000 reviews)
"Air conditioner was just fine, a sage place to stay."
Valorie
The price is HK$461
HK$540 total
includes taxes & fees
15 Jan - 16 Jan
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD28.8 km from South Main
9.0 out of 10, Wonderful, (974 reviews)
"Area is nice and quiet. Hotel was clean. "
Isabel
The price is HK$617
HK$722 total
includes taxes & fees
21 Jan - 22 Jan
Hampton Inn & Suites Houston I-10 West Park Row
Hampton Inn & Suites Houston I-10 West Park Row29.3 km from South Main
8.8 out of 10, Excellent, (671 reviews)
"Great staff, Clean room. "
Corliss
The price is HK$561
HK$662 total
includes taxes & fees
20 Jan - 21 Jan
Moxy Houston Downtown
Moxy Houston DowntownDowntown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (701 reviews)
"Staff was very pleasant and the rooms were clean."
Elizabeth
The price is HK$769
HK$918 total
includes taxes & fees
18 Jan - 19 Jan
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (153 reviews)
"Such a great place to stay! Absolutely amazing!"
Charlette
The price is HK$684
HK$825 total
includes taxes & fees
27 Jan - 28 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Blossom Hotel Houston, Curio Collection by Hilton
10/10 Excellent
