Lodging Image

Southeast Missouri hotels from HK$433

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Star rating

Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place!"
United States
Jennifer
The price is HK$831
HK$956 total
includes taxes & fees
2 Jul - 3 Jul
Drury Inn & Suites Sikeston, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is HK$784
HK$885 total
includes taxes & fees
12 Jul - 13 Jul
Drury Plaza Hotel Cape Girardeau Conference Center

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (925 reviews)
"Hotel Staff was very friendly!"
United States
Alice
The price is HK$792
HK$895 total
includes taxes & fees
12 Jul - 13 Jul
Fairfield Inn & Suites by Marriott Poplar Bluff

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (472 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is HK$823
HK$932 total
includes taxes & fees
26 Jul - 27 Jul
Holiday Inn Express & Suites Sikeston Southwest by IHG

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (879 reviews)
"Nice quiet overnight stay."
United States
Tammy
The price is HK$765
HK$857 total
includes taxes & fees
12 Jul - 13 Jul
Hampton Inn Poplar Bluff

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (581 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is HK$797
HK$903 total
includes taxes & fees
19 Jul - 20 Jul
Hampton Inn Sikeston

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (788 reviews)
"Beautiful hotel at a very good price."
United States
Sheldon
The price is HK$726
HK$786 total
includes taxes & fees
30 Jun - 1 Jul
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (203 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
The price is HK$727
HK$820 total
includes taxes & fees
9 Jul - 10 Jul
Fairfield Inn & Suites by Marriott Cape Girardeau

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (525 reviews)
"Great stay!!"
United States
Taylor
The price is HK$1,087
HK$1,232 total
includes taxes & fees
26 Jul - 27 Jul
Courtyard by Marriott Cape Girardeau Downtown

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel"
United States
mason
The price is HK$565
HK$637 total
includes taxes & fees
26 Jul - 27 Jul
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is HK$643
HK$680 total
includes taxes & fees
26 Jul - 27 Jul
Drury Inn & Suites Jackson MO

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very good, (1,001 reviews)
"Enjoyed our stay "
United States
Cynthia
The price is HK$553
HK$633 total
includes taxes & fees
13 Jul - 14 Jul
Super 8 by Wyndham Perryville

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (635 reviews)
"Excellent staff and location was nice and quiet "
United States
Colleen
The price is HK$860
HK$936 total
includes taxes & fees
19 Jul - 20 Jul
Crown Pointe Lodge, BW Signature Collection

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (599 reviews)
"Beautiful new hotel didn’t disappoint! Rey comfortable beds. Great breakfast and attentive staff keeping things filed for the best guest experience. I would definitely stop there again on my next trip through Perryville!"
United States
Cheryl
The price is HK$862
HK$987 total
includes taxes & fees
3 Jul - 4 Jul
Holiday Inn Express & Suites Perryville by IHG

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (611 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
United States
John
The price is HK$1,037
HK$1,170 total
includes taxes & fees
1 Jul - 2 Jul
The Riverview

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (825 reviews)
"A nice stay"
United States
DAVID
The price is HK$830
HK$936 total
includes taxes & fees
12 Jul - 13 Jul
Hampton Inn Cape Girardeau I 55 East

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (140 reviews)
The price is HK$701
HK$798 total
includes taxes & fees
5 Jul - 6 Jul
Tru By Hilton Cape Girardeau

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (96 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is HK$792
HK$897 total
includes taxes & fees
5 Jul - 6 Jul
Fairfield Inn & Suites by Marriott Sikeston

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
7.8 out of 10, Good, (1,001 reviews)
"Clean room, check in was easy. It was a good stopover for 1 night."
United States
Nancy
The price is HK$699
HK$799 total
includes taxes & fees
29 Jun - 30 Jun
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
The price is HK$377
HK$436 total
includes taxes & fees
28 Jun - 29 Jun
Deerfield Inn & Suites Steele Near Blytheville I 55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southeast Missouri

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Walnut Hollow Lake to K Bridge Recreation Area.

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia