Our top choices for Southern Illinois hotels

Hampton Inn & Suites Effingham

Effingham

HK$1,063 total

includes taxes & fees

3 Jul - 4 Jul

Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

HK$1,129 total

includes taxes & fees

4 Jul - 5 Jul

Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

HK$1,036 total

includes taxes & fees

5 Jul - 6 Jul

Comfort Suites Mount Vernon

Mount Vernon

Todd

HK$1,082 total

includes taxes & fees

28 Jun - 29 Jun

Holiday Inn Effingham by IHG

Effingham

Glenn

HK$922 total

includes taxes & fees

9 Jul - 10 Jul

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jennifer

HK$731 total

includes taxes & fees

26 Jul - 27 Jul

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

HK$940 total

includes taxes & fees

5 Jul - 6 Jul

Best Western Delta Inn

Effingham

Bri

HK$851 total

includes taxes & fees

19 Jul - 20 Jul

Cobblestone Inn & Suites - Altamont

Altamont

Dominic

HK$838 total

includes taxes & fees

27 Jun - 28 Jun

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Rickey

HK$703 total

includes taxes & fees

3 Jul - 4 Jul

Fairfield Inn & Suites Marriott Effingham

Effingham

HK$835 total

includes taxes & fees

19 Jul - 20 Jul

Drury Inn & Suites Marion

Marion

Brandy

HK$1,053 total

includes taxes & fees

20 Jul - 21 Jul

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Melissa

HK$1,077 total

includes taxes & fees

2 Jul - 3 Jul

Comfort Inn & Suites Marion I-57

Marion

HK$1,143 total

includes taxes & fees

21 Jul - 22 Jul

Best Western Plus Parkside Inn & Suites

Olney

James

HK$1,102 total

includes taxes & fees

8 Jul - 9 Jul

Hampton Inn St. Louis - Columbia

Columbia

Angie

HK$899 total

includes taxes & fees

2 Jul - 3 Jul

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Suzanne

HK$760 total

includes taxes & fees

5 Jul - 6 Jul

The Principal Hotel

Columbia

Michelle

HK$982 total

includes taxes & fees

2 Jul - 3 Jul

In-room safe, desk, iron/ironing board, cots/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Dawn

HK$580 total

includes taxes & fees

5 Jul - 6 Jul

Country Inn & Suites by Radisson, Marion, IL

Marion

Gregory

HK$1,021 total

includes taxes & fees

20 Jul - 21 Jul

View all properties

Holiday Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Southern Illinois attractions

A rocky landscape with a sunset in the background.

Garden of the Gods Recreation Area

9.8/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

The Principal Hotel

10/10 Excellent

"Cute hotel in small town with good local restaurants within walking distance. Very clean and neat. Easy parking"

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"From door to door great employee’s great breakfast and dinner comes with the stay. Well maintained one of the best places we stayed at. 2nd time if we in the area and need a place they get my business. FYI really good selection of nearby restaurants.👍👍 Thank You so much !"

Walker's Bluff Casino Resort

10/10 Excellent

"We visited this casino for the first time and also stayed at the hotel. Although there are no other businesses within several miles, this location had everyone we needed. The hotel was nice and connected to the casino and restaurants. The casino had many of the newer slots we play and is not so huge that it required a great deal of walking. The restaurants and sports bar served a variety of good food at reasonable prices."