Best St. Charles Hotels in 2026 from HK$441 - Fully Refundable Options

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Our top choices for St. Charles hotels

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern indoor pool area with lounge chairs and a pool.

1. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Kimberley

HK$995

HK$1,146 total

includes taxes & fees

30 Oct - 31 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A hotel room with a bed, desk, chair, and a bathroom.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

2. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

HK$643

HK$740 total

includes taxes & fees

7 Nov - 8 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

3. Hampton Inn Rochester-South

Rochester

dennis

HK$766

HK$882 total

includes taxes & fees

8 Nov - 9 Nov

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A hotel with a covered entrance, multiple floors, and a parking lot.

4. Spark by Hilton Rochester South

Rochester

Stanton

HK$526

HK$606 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

5. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

HK$859

HK$989 total

includes taxes & fees

7 Nov - 8 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

6. AmericInn by Wyndham Winona

Winona

Jonathan

HK$994

HK$1,109 total

includes taxes & fees

1 Nov - 2 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern lounge area with seating, a fireplace, and a bar area.

7. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

HK$1,034

HK$1,191 total

includes taxes & fees

14 Nov - 15 Nov

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

A cozy living room with a fireplace, a staircase, and a dining area.

8. Stone Mill Hotel & Suites

Lanesboro

Bernie

HK$823

HK$884 total

includes taxes & fees

3 Nov - 4 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

9. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Deanna

HK$895

HK$1,030 total

includes taxes & fees

24 Oct - 25 Oct

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A hotel room with a desk, a chair, a flat-screen TV mounted on the wall, and a lamp on the desk.

A gym with treadmills, elliptical machines, and a stationary bike.

A snack bar with a variety of packaged snacks, a refrigerator stocked with beverages, and a microwave.

10. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Terri

HK$604

HK$695 total

includes taxes & fees

22 Nov - 23 Nov

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A reception area with a curved counter, ceiling lights, and a potted plant.

11. Brentwood Inn & Suites

Downtown Rochester

Elaine

HK$940

HK$1,083 total

includes taxes & fees

29 Oct - 30 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

12. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Cory

HK$1,074

HK$1,236 total

includes taxes & fees

6 Nov - 7 Nov

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A bar with wooden stools and a neon sign.

A hotel room with two beds, a desk, a chair, and a mirror.

An indoor swimming pool with a slide, seating area, and a large frog statue.

13. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

blake

HK$579

HK$667 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

14. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Brien

HK$910

HK$1,047 total

includes taxes & fees

6 Nov - 7 Nov

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A reception area with two counters, a patterned wall, and a wooden floor.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

15. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester

Richard

HK$926

HK$1,066 total

includes taxes & fees

7 Nov - 8 Nov

A hotel room with two beds, a desk, a chair, and a lamp.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

16. Country Trails Inn & Suites

Preston

Jeannie

HK$991

HK$1,094 total

includes taxes & fees

25 Oct - 26 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

17. Quality Inn & Suites Mayo Clinic Area

Rochester

Jessica

HK$534

HK$623 total

includes taxes & fees

13 Nov - 14 Nov

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

18. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Alvaro

HK$586

HK$675 total

includes taxes & fees

8 Nov - 9 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

19. Econo Lodge Mayo Clinic Area

Rochester

Ashley

HK$518

HK$597 total

includes taxes & fees

15 Nov - 16 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

20. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

James

HK$862

HK$1,098 total

includes taxes & fees

6 Nov - 7 Nov

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Top St. Charles Hotel Reviews

Hotel Indigo Rochester – Mayo Clinic Area by IHG

8/10 Good

"Parking was an additional fee but the walk wasn't bad and there was a skyway. The beds had some hair on the outer most layers, I suspect housekeeping didn't use their lint rollers on that part. Housekeeping knocked on our door and tried to enter despite us hanging the do not disturb sign and getting a late checkout with front desk, which was a bit alarming early in the morning."

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Room was spotless. Staff was very helpful."

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

8/10 Good

"Great staff, the hotel needs some updating."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"This hotel was very convenient to Mayo, just a five minute walk. It was especially nice to stay so close to mayo and yet avoid dealing with the construction. Parking was easy to get to if you use the ramp across the street from the hotel. Overall the hotel is a bit dated but very clean. The beds could use replacing as the mattress was saggy. We liked having the extra room of a suite as well as the mini kitchen."

Kahler Grand Hotel

8/10 Good

"Can’t go to a Kahler Grand restaurant and get breakfast. They only have room service for breakfast!"

The Plaza Hotel & Suites Winona

8/10 Good

"Wa"

Express Suites Riverport Inn & Suites

10/10 Excellent

"Nice hotel clean.."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Very nice place, convient, clean"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"."

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

HK$388

HK$441 total

15 Nov - 16 Nov

includes taxes & fees

Quality Inn near Medical Center

5708 Bandel Road NW Rochester MN

HK$493

HK$567 total

12 Nov - 13 Nov

includes taxes & fees

7.8/10 Good! (982 reviews)

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

HK$592

HK$682 total

24 Oct - 25 Oct

includes taxes & fees

7.8/10 Good! (1,033 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

HK$643

HK$740 total

7 Nov - 8 Nov

includes taxes & fees

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

HK$742

HK$854 total

28 Oct - 29 Oct

includes taxes & fees

8.2/10 Very good! (1,002 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

HK$940

HK$1,083 total

29 Oct - 30 Oct

includes taxes & fees

Hotels in St. Charles with star-rating

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

What are some of the best holiday rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of St. Charles offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

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St. Charles hotels from HK$441

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. Hyatt House Rochester/Mayo Clinic Area

2. Holiday Inn Express Rochester South - Mayo Area by IHG

3. Hampton Inn Rochester-South

4. Spark by Hilton Rochester South

5. Home2 Suites by Hilton Rochester Mayo Clinic Area

6. AmericInn by Wyndham Winona

7. Residence Inn by Marriott Rochester Mayo Clinic Area South

8. Stone Mill Hotel & Suites

9. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10. Comfort Inn & Suites Rochester South Mayo Clinic

11. Brentwood Inn & Suites

12. TownePlace Suites by Marriott Rochester Mayo Clinic Area

13. AmericInn by Wyndham Rochester Near Mayo Clinic

14. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

15. Hilton Garden Inn Rochester Downtown, MN

16. Country Trails Inn & Suites

17. Quality Inn & Suites Mayo Clinic Area

18. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

19. Econo Lodge Mayo Clinic Area

20. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Learn more about St. Charles

Top St. Charles Hotel Reviews

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Kahler Inn and Suites - Mayo Clinic Area

Kahler Grand Hotel

The Plaza Hotel & Suites Winona

Express Suites Riverport Inn & Suites

Hyatt House Rochester/Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Quality Inn near Medical Center

Med City Inn & Suites - Mayo Clinic Area

Holiday Inn Express Rochester South - Mayo Area by IHG

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Brentwood Inn & Suites

Hotels in St. Charles with star-rating

Frequently asked questions

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