Photo by RVLuckyorWhat

Upstate South Carolina Holiday Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
2 Jan - 4 Jan
In two months
13 Feb - 15 Feb
In three months
13 Mar - 15 Mar
In four months
10 Apr - 12 Apr

Our top choices for Upstate South Carolina holiday rentals

Meeting facility
Mint House Greenville - Downtown

Apartment in Greenville Downtown

Mint House Greenville - Downtown
4.0 star property
9.2 out of 10, Wonderful, (774)
"Excellent stay as always! "
United States
Elena
The price is HK$904
HK$1,021 total
includes taxes & fees
11 Jan - 12 Jan 2026
Mint House Greenville - Downtown
Full-sized fridge, microwave, oven, stovetop
stayAPT Suites Greenville-Haywood Mall

Aparthotel in Greenville

stayAPT Suites Greenville-Haywood Mall
3.0 star property
9.0 out of 10, Wonderful, (196)
"Great place!"
United States
Daecia
The price is HK$817
HK$899 total
includes taxes & fees
16 Dec - 17 Dec
stayAPT Suites Greenville-Haywood Mall
Interior
Wooded Cottage - 3 Mi to Clemson University

Cottage in Clemson

Wooded Cottage - 3 Mi to Clemson University
3.0 star property
10.0 out of 10, Exceptional, (1)
Wooded Cottage - 3 Mi to Clemson University
Exterior
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Cabin in Seneca

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
9.8 out of 10, Exceptional, (51)
"The place was absolutely magnificent."
United States
David
The price is HK$693
HK$1,105 total
includes taxes & fees
16 Dec - 17 Dec
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2 bedrooms, iron/ironing board, free WiFi, bed sheets
Stylish Downtown Greenville Apartment 1 Block Off Main Street

Apartment in Greenville Downtown

Stylish Downtown Greenville Apartment 1 Block Off Main Street
2.0 star property
10.0 out of 10, Exceptional, (7)
The price is HK$483
HK$1,046 total
includes taxes & fees
21 Dec - 22 Dec
Stylish Downtown Greenville Apartment 1 Block Off Main Street
2 bedrooms, free WiFi, bed sheets
Stylish Downtown Greenville Apartment 1 Block Off Main Street

Apartment in Greenville Downtown

Stylish Downtown Greenville Apartment 1 Block Off Main Street
2.0 star property
9.2 out of 10, Wonderful, (7)
The price is HK$537
HK$1,105 total
includes taxes & fees
30 Dec - 31 Dec
Stylish Downtown Greenville Apartment 1 Block Off Main Street
Terrace/patio
The Station by Compo Hotels

Aparthotel in Travelers Rest

The Station by Compo Hotels
4.0 star property
10.0 out of 10, Exceptional, (15)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is HK$1,427
HK$2,211 total
includes taxes & fees
15 Jan - 16 Jan 2026
The Station by Compo Hotels
Private kitchen
Park Place Apartments by Landing

Aparthotel in Greenville

Park Place Apartments by Landing
4.0 star property
7.6 out of 10, Good, (42)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Exterior detail
Riverwalk Falls-lovely one bedroom condo

Condo in Greenville Downtown

Riverwalk Falls-lovely one bedroom condo
10.0 out of 10, Exceptional, (174)
"An amazing location and great stay!"
United States
Amanda S.
The price is HK$778
HK$1,584 total
includes taxes & fees
17 Dec - 18 Dec
Riverwalk Falls-lovely one bedroom condo
Outdoor spa tub
Lazy Bear Retreat by the Creek

Cabin in Pickens

Lazy Bear Retreat by the Creek
10.0 out of 10, Exceptional, (45)
"Clean , rustic interior, nothing fancy. "
United States
Robert
The price is HK$666
HK$1,430 total
includes taxes & fees
16 Dec - 17 Dec
Lazy Bear Retreat by the Creek
Microwave, oven, stovetop, dishwasher
Upscale Artsy Bungalow-Walk away to Unity Park

Holiday Home in Greenville

Upscale Artsy Bungalow-Walk away to Unity Park
10.0 out of 10, Exceptional, (5)
The price is HK$1,479
HK$3,040 total
includes taxes & fees
16 Dec - 17 Dec
Upscale Artsy Bungalow-Walk away to Unity Park
Fridge, microwave, oven, stovetop
Spacious 4-bedroom home in charming Travelers Rest with WiFi & Firepit.

Holiday Home in Travelers Rest

Spacious 4-bedroom home in charming Travelers Rest with WiFi & Firepit.
10.0 out of 10, Exceptional, (17)
"Great location, clean place, great communication would come back again."
United States
Jeff S.
The price is HK$973
HK$2,655 total
includes taxes & fees
5 Jan - 6 Jan 2026
Spacious 4-bedroom home in charming Travelers Rest with WiFi & Firepit.
Terrace/patio
The Mountains are calling for You and Yours!

Cabin in Cleveland

The Mountains are calling for You and Yours!
9.8 out of 10, Exceptional, (113)
"Our family of 5 stayed for a visit to The Pretty Place Chapel. House was great, everyone had their own little personal space. Great location to not only The Pretty Place Chapel but many other sights like waterfalls, hiking trails, wonderful restaurants & coffee shops. Would say a 10 out of 10 trip! "
United States
Tiffany B.
The Mountains are calling for You and Yours!
Smart TV, fireplace, books
Deep Water-Keowee Lakefront,Kayaks, Dock, Dog friendly,level water entry, kayaks

Holiday Home in Seneca

Deep Water-Keowee Lakefront,Kayaks, Dock, Dog friendly,level water entry, kayaks
9.8 out of 10, Exceptional, (65)
"Wonderful experience! Great home, location and host."
United States
Christine V.
Deep Water-Keowee Lakefront,Kayaks, Dock, Dog friendly,level water entry, kayaks
Property grounds
Modern Condo in the Heart of Downtown Greenville

Condo in Greenville Downtown

Modern Condo in the Heart of Downtown Greenville
9.6 out of 10, Exceptional, (105)
"Great location, clean, good communication with the host"
United States
Michael R.
The price is HK$1,226
HK$2,411 total
includes taxes & fees
16 Dec - 17 Dec
Modern Condo in the Heart of Downtown Greenville
Exterior
Hickory Cottage - 1bdrm Retreat

Cottage in Taylors

Hickory Cottage - 1bdrm Retreat
10.0 out of 10, Exceptional, (46)
"The cottage was absolutely gorgeous and so clean. The host were so nice and answered any questions we had. 100% recommend staying here as it was a wonderful place to stay. We will be back to stay here for sure. It's one home we wouldnt hesitate staying at again because I loved every minute there. "
United States
Michael & Stephanie L.
Hickory Cottage - 1bdrm Retreat
Exterior
Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard

Holiday Home in Greer

Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard
2.0 star property
10.0 out of 10, Exceptional, (8)
"Yes. The house was very nice. "
United States
Karen
Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard
Private kitchen
2BR 2Bath - Swamp Rabbit Trail Resort

Apartment in Greenville

2BR 2Bath - Swamp Rabbit Trail Resort
9.2 out of 10, Wonderful, (24)
"Great location and clean condo! We loved the Swamp Rabbit Cafe for breakfast and walking on the swanp rabbit trail, all super close to easily walk to. "
United States
linda S.
The price is HK$553
HK$1,508 total
includes taxes & fees
22 Dec - 23 Dec
2BR 2Bath - Swamp Rabbit Trail Resort
Exterior
Historic 19th Century Cabin in Greenville

Cabin in Greenville

Historic 19th Century Cabin in Greenville
10.0 out of 10, Exceptional, (5)
"Great cabin in the perfect location. Hosts have thought of everything. Will definitely stay here again! "
United States
David R.
The price is HK$708
HK$1,293 total
includes taxes & fees
22 Dec - 23 Dec
Historic 19th Century Cabin in Greenville
Dining
Private, pet-friendly adorable getaway mins to downtown

Holiday Home in Greenville

Private, pet-friendly adorable getaway mins to downtown
9.6 out of 10, Exceptional, (110)
"The best! Our home-away-from-home when visiting our son at Furman. Thank you, Yamileth! "
United States
Aletta M.
The price is HK$1,168
HK$2,415 total
includes taxes & fees
4 Jan - 5 Jan 2026
Private, pet-friendly adorable getaway mins to downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Upstate South Carolina Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"It was great! Comfortable and clean!"
Kathleen 1-night trip
Posted 17 hours ago
Embassy Suites Greenville Golf Resort & Conference Center

Find out more about Upstate South Carolina

Search for holiday rentals in Upstate South Carolina on Expedia! You can easily find your home rentals, villas, holiday apartments in Upstate South Carolina using one of the methods below:

  • View our selection of featured holiday rentals in Upstate South Carolina
  • Use the map to find apartments and other holiday homes in the Upstate South Carolina neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Upstate South Carolina while they last

Look no further and take a look at our great range of rental properties in Upstate South Carolina!