Luxury Holidays in Northeast Missouri 2026

Photo by Andrew Hershfeld

Plan, book, travel with confidence
Better together
Save up to HK$7,200 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy free Wi-Fi, an outdoor pool and 3 restaurants. Our guests praise the helpful staff and the clean rooms in their ...

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants and a casino. Our guests praise the clean rooms in their reviews. Popular attractions ...

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff and the room service ...

9.2/10 Wonderful! (586 reviews)

"Don't eat at the restaurant. The food was awful. The service was horrible, maybe worst I've ever had. Couldn't get orders. Couldn't get refills. Server not once asked how the food or drinks were (they were awful as well). And it was an anniversary dinner for us and stay. Hotel pillows were horrible. ..."

Reviewed on 8 Sept 2026

See all 3,016 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.