Best Cape Girardeau Hotels in 2026 from HK$527 - Fully Refundable Options

A calm body of water, a sandy beach, and a forested area in the distance.

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Our top choices for Cape Girardeau hotels

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

HK$793

HK$902 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

HK$785

HK$885 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

3. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

HK$730

HK$823 total

includes taxes & fees

11 Oct - 12 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

4. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

HK$794

HK$895 total

includes taxes & fees

11 Oct - 12 Oct

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

5. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

HK$830

HK$936 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

6. The Riverview

Cape Girardeau

Alyssa

HK$897

HK$1,012 total

includes taxes & fees

7 Oct - 8 Oct

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

A lobby with seating areas, a reception desk, and a bar.

A spacious living room with a sofa set, a coffee table, and a dining area.

7. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

HK$982

HK$1,112 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

8. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

HK$565

HK$637 total

includes taxes & fees

11 Oct - 12 Oct

A modern retail area with a display of local items and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

HK$701

HK$798 total

includes taxes & fees

11 Oct - 12 Oct

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

A hotel room with a bed, a TV, a desk, and a chair.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

10. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

Samuel

HK$667

HK$796 total

includes taxes & fees

11 Oct - 12 Oct

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

11. Quality Inn Cape Girardeau North

Cape Girardeau

Danny

HK$467

HK$527 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

A bathroom with a marble wall and a white bathtub.

12. Town House Inn Cape Giradreau

Cape Girardeau

Joshua

HK$589

HK$688 total

includes taxes & fees

6 Oct - 7 Oct

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

HK$634

HK$686 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

14. Drury Inn & Suites Jackson MO

Jackson

Thomas

HK$628

HK$664 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

15. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

HK$594

HK$642 total

includes taxes & fees

29 Oct - 30 Oct

A living room with a blue wall, a fireplace, a sofa, and a chair.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A bar area with stools and a counter where a bartender is serving drinks.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

16. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

HK$825

HK$898 total

includes taxes & fees

8 Oct - 9 Oct

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

17. Town House Inn

Jackson

Taylor

HK$559

HK$605 total

includes taxes & fees

6 Oct - 7 Oct

A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

A cozy log cabin interior with a wooden staircase, a cushioned sofa, a small table, and a lamp.

A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

18. Makanda Inn

Makanda

Michele

HK$2,056

HK$2,343 total

includes taxes & fees

6 Oct - 7 Oct

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Stay near popular Cape Girardeau attractions

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)

Enjoy panoramic views of the Mississippi River and Bill Emerson Memorial Bridge from this peaceful riverside park. Stroll along the well-maintained walking paths and find perfect spots for memorable photographs.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Hunter Valley Winery

7.4/10 (48 reviews)

Sip award-winning Chambourcin and Chardonnay at this picturesque Missouri estate with lake views. Bring a picnic basket and enjoy live weekend music on the deck overlooking the sculpture garden.

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Riverfront Park

8.0/10 (2 reviews)

This riverside haven features terraced seating overlooking the Mississippi and a flood wall adorned with historical murals. Stroll the riverfront trail while watching paddle boats dock at this picturesque park.

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Show Me Center

8.6/10 (40 reviews)

The Show Me Centre hosts Southeast Missouri State basketball and major concerts in a versatile arena setting. Catch Redhawks games or enjoy performances by renowned artists in this regional entertainment hub.

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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)

This 3.5-acre water park thrills with a 265-foot free-fall slide and 700-foot lazy river. Families can splash in the pirate ship playground or relax in shaded lounge areas during summer months.

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eDen Spa & Salon

7.8/10 (25 reviews)

Cape Girardeau's only AVEDA Concept spa resides in a historic 1800s Colonial home blending antique charm with modern amenities. Book a massage or facial and arrive early to enjoy the infrared sauna before your treatment.

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Learn more about Cape Girardeau

Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.

See all hotels in Cape Girardeau

A nighttime view of a bridge with its cables illuminated against a starry sky.

Top Cape Girardeau Hotel Reviews

The Riverview

10/10 Excellent

"We were passing through and pleasantly surprised! Clean, well appointed, super friendly staff - everyone seemed happy t work there, and all around great. A real Starbucks in the lobby plus extra security because of the casino in the parking lot were huge plusses. 😊"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Perfect location, beds were awesome & staff were friendly & accommodating!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

10/10 Excellent

"We’ve been staying at Chip’s house the past two years during the fair! It’s always comfy and cozy! Chip’s fabulous!"

Hampton Inn Cape Girardeau I 55 East

8/10 Good

"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Very nice! Bed was comfortable and room had a very large bathroom and shower. Towels were thick and fluffy. Enjoyed having a bar downstairs with a fun friendly staff. Will stay there again when I’m coming through."

The Little Cape Lofted Cottage | Creek & Nature

8/10 Good

"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked away property. I did feel like it was a bit overpriced."

Town House Inn Cape Giradreau

8/10 Good

"The outside needed cleaning, but the room was very clean and well maintained."

More cheap stays in Cape Girardeau

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

HK$467

HK$527 total

1 Nov - 2 Nov

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

HK$565

HK$637 total

11 Oct - 12 Oct

includes taxes & fees

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

HK$667

HK$796 total

11 Oct - 12 Oct

includes taxes & fees

8/10 Very good! (1,001 reviews)

Tru By Hilton Cape Girardeau

2520 Veterans Memorial Dr Cape Girardeau MO

HK$701

HK$798 total

11 Oct - 12 Oct

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

HK$793

HK$902 total

11 Oct - 12 Oct

includes taxes & fees

9.4/10 Exceptional! (1,004 reviews)

Hotel 7 Inn Anna

100 Richview Dr Anna IL

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Frequently asked questions

What's the best place to stay in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is one of the top choices for your stay based on our traveller data. This hotel offers free breakfast and a restaurant. Other good options for your visit include The Riverview and Pear Tree Inn Cape Girardeau West. See all available top hotels, or vacation rentals in Cape Girardeau.

What are some of the best holiday rentals that Cape Girardeau has to offer?

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau: This highly rated holiday home rental in Cape Girardeau is equipped with a BBQ, air conditioning and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge and a stovetop. Other favourite homes for rent in Cape Girardeau are "Brickyard"-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau and Little Blue Cottage on Spanish. See all vacation rentals in Cape Girardeau.

If I need to cancel my hotel reservation in Cape Girardeau, will I receive a refund?

Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Cape Girardeau.

What's the best accommodation for a budget-friendly stay in Cape Girardeau?

Based on reviews, Pear Tree Inn Cape Girardeau West is a popular hotel for our travellers who want a more economical choice, and features free buffet breakfast and free Wi-Fi. View all budget hotels in Cape Girardeau.

What's the best family accommodation in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Pear Tree Inn Cape Girardeau West is another good option for your stay with the kids. Also, attractions such as Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are fun for children of all ages. Find more child-friendly accommodations in Cape Girardeau.

What's the best LGBTQ-friendly hotel in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Candlewood Suites Cape Girardeau by IHG and Pear Tree Inn Cape Girardeau West are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Cape Girardeau.

What's the best dog-friendly hotel in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a top hotel for people travelling with their pets, and offers a restaurant and free WiFi for its human guests. Two other good options for you and your pet's trip include Candlewood Suites Cape Girardeau by IHG and Pear Tree Inn Cape Girardeau West. See more pet-friendly hotel accommodations in Cape Girardeau.

What are some accommodation options with pools in Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top hotel with a pool, a full-service spa and free WiFi. View all hotels with pools in Cape Girardeau.

What is the best spa hotel in Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness centre. See all spa hotels in Cape Girardeau.

What is staying in Cape Girardeau like?

History buffs will enjoy exploring Cape Girardeau, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its riverfront, university setting and shopping. In Cape Girardeau, there are 69 hotels and other accommodation options to choose from. Find out more about Cape Girardeau.

What should I do while I'm visiting Cape Girardeau?

Favorite family attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. Landmarks like The Glenn House and Fort D Historic Site might be worth a visit. The picturesque setting of Shawnee National Forest and Mississippi River exemplify the area's natural beauty. Take a look at what more there is to see and do in Expedia's Cape Girardeau guide.

What's the weather like in Cape Girardeau?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cape Girardeau is 1495 mm.

Cape Girardeau hotels from HK$527

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Cape Girardeau

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Cape Girardeau hotels

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2. Drury Plaza Hotel Cape Girardeau Conference Center

3. Drury Inn & Suites Cape Girardeau

4. Fairfield Inn & Suites by Marriott Cape Girardeau

5. Hampton Inn Cape Girardeau I 55 East

6. The Riverview

7. Courtyard by Marriott Cape Girardeau Downtown

8. Pear Tree Inn Cape Girardeau West

9. Tru By Hilton Cape Girardeau

10. Candlewood Suites Cape Girardeau by IHG

11. Quality Inn Cape Girardeau North

12. Town House Inn Cape Giradreau

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

14. Drury Inn & Suites Jackson MO

15. Comfort Suites Jackson-Cape Girardeau

16. EC Reed's Mercantile and Hotel

17. Town House Inn

18. Makanda Inn

Stay near popular Cape Girardeau attractions

Southeast Missouri State University

Riverfront Bridge Park

Century Casino & Hotel Cape Girardeau

Hunter Valley Winery

Riverfront Park

Show Me Center

Cape Splash Family Aquatic Center

eDen Spa & Salon

Learn more about Cape Girardeau

Top Cape Girardeau Hotel Reviews

The Riverview

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Candlewood Suites Cape Girardeau by IHG

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Hampton Inn Cape Girardeau I 55 East

Courtyard by Marriott Cape Girardeau Downtown

The Little Cape Lofted Cottage | Creek & Nature

Town House Inn Cape Giradreau

More cheap stays in Cape Girardeau

Quality Inn Cape Girardeau North

Pear Tree Inn Cape Girardeau West

Candlewood Suites Cape Girardeau by IHG

Tru By Hilton Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotel 7 Inn Anna

Frequently asked questions

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