Best Defiance Hotels in 2026 from HK$714 - Fully Refundable Options

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A modern hotel room with a desk, chair, and a large mirror.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

HK$730

HK$861 total

includes taxes & fees

19 Oct - 20 Oct

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

2. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

HK$934

HK$1,096 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A hotel lobby with a reception desk, seating area, and a large potted plant.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

HK$647

HK$763 total

includes taxes & fees

8 Nov - 9 Nov

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

A hotel room with a desk, chair, sofa, and a window with curtains.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

HK$730

HK$861 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

5. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

HK$1,028

HK$1,213 total

includes taxes & fees

1 Nov - 2 Nov

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

An indoor swimming pool with a blue interior, surrounded by white chairs and tables, and a blue ceiling.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

6. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

HK$660

HK$796 total

includes taxes & fees

27 Oct - 28 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

7. The Wildwood Hotel

Wildwood

Rachell

HK$649

HK$756 total

includes taxes & fees

26 Oct - 27 Oct

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

HK$849

HK$1,007 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

9. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

HK$946

HK$1,098 total

includes taxes & fees

18 Oct - 19 Oct

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

10. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

HK$927

HK$1,079 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel lobby with a seating area, a map mural, and a television.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A coffee station with two coffee machines and a display of coffee pods and cups.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

HK$840

HK$977 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio area with wicker furniture and a central fire feature.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

12. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

HK$911

HK$1,060 total

includes taxes & fees

29 Oct - 30 Oct

A spacious lobby with a central round table, two sofas, and a chandelier.

A buffet setup with various food items and a decorative vase of flowers.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

13. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Chasity

HK$1,020

HK$1,183 total

includes taxes & fees

21 Oct - 22 Oct

Two people in a swimming pool with colorful inflatable rings.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

14. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

HK$1,052

HK$1,225 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio with a built-in grill, seating area, and stone walls.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

A multi-story hotel with a parking lot in front.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

15. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Chelsea

HK$1,483

HK$1,735 total

includes taxes & fees

26 Oct - 27 Oct

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A hotel room with orange furniture, a glass coffee table, a dining area with a table and chairs, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, a mirror, and a wardrobe.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

16. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

Saranne

HK$1,088

HK$1,261 total

includes taxes & fees

30 Oct - 31 Oct

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

17. Comfort Inn Near Six Flags St. Louis

Pacific

Gail

HK$697

HK$798 total

includes taxes & fees

9 Nov - 10 Nov

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

18. Quality Inn Near Six Flags St. Louis

Pacific

Chantelle

HK$664

HK$760 total

includes taxes & fees

9 Nov - 10 Nov

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

A modern hotel room with a neatly made bed, a bedside table with a lamp, a wall-mounted artwork, and a small seating area with a bench.

A snack display area with various chips and snacks, a refrigerated section, and a wall with a 'Treats' sign.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

19. Hampton Inn St. Louis Wentzville

Wentzville

Jill

HK$1,127

HK$1,279 total

includes taxes & fees

1 Nov - 2 Nov

A hotel reception area with a counter, coffee machines, a refrigerated display, and artwork on the wall.

A snack bar with shelves of chips, candies, and bottled water.

An indoor swimming pool with clear water, a diving board, and a seating area with tables and chairs.

A hotel room with a bed, desk, TV, and a view of the outdoors.

20. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Chesterfield

Charles

HK$841

HK$975 total

includes taxes & fees

27 Oct - 28 Oct

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Ameristar Casino Resort and Spa

10/10 Excellent

"Very clean and professional"

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Staff were all very helpful and welcoming! Breakfast and kick back dinner were wonderful! Room was great and comfortable with plenty of room but halls were dirty. Loved the parking garage. Overall, our favorite place to stay! Would highly recommend it!"

Drury Inn & Suites Southwest St. Louis

10/10 Excellent

"We've stayed here before and enjoy the cocktail hour and a great BBQ place, sugar fire, next door. The breakfast is always great. Please tip the gals working it."

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"Nice place"

The Wildwood Hotel

10/10 Excellent

"Clean, quiet, great continental breakfast, and close to several places to eat."

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"Room was clean, breakfast was good, no problems checking in or out. I have stayed twice and will stay again."

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Excellent location. Good parking. Clean rooms."

Wingate by Wyndham St. Louis/Fenton Route 66

10/10 Excellent

"Clean, comfortable, easy access. Good Price, Perfect for a 4 day stay."

More cheap stays in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

HK$622

HK$714 total

15 Nov - 16 Nov

includes taxes & fees

8/10 Very good! (1,000 reviews)

Quality Inn Foristell

12 Highway W Foristell MO

HK$647

HK$731 total

15 Nov - 16 Nov

includes taxes & fees

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

HK$647

HK$763 total

8 Nov - 9 Nov

includes taxes & fees

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

HK$745

HK$856 total

15 Nov - 16 Nov

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

HK$931

HK$1,070 total

25 Oct - 26 Oct

includes taxes & fees

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

HK$961

HK$1,104 total

15 Nov - 16 Nov

includes taxes & fees

9.4/10 Exceptional! (1,103 reviews)

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

What are some of the best holiday rentals that Defiance has to offer?

HotTub-2br2b-near Historic Main Street: This holiday home rental outside of Defiance offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. Make the most of Access to hot tub in this rental home to help you unwind. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Defiance hotels from HK$714

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

2. TownePlace Suites by Marriott St. Louis Chesterfield

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

4. Staybridge Suites O'Fallon Chesterfield by IHG

5. Residence Inn by Marriott O'Fallon

6. Comfort Inn & Suites Chesterfield - St. Louis

7. The Wildwood Hotel

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Hyatt Place St. Louis/Chesterfield

10. Hampton Inn & Suites St. Louis/Chesterfield

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

12. Courtyard by Marriott St. Louis Chesterfield

13. Drury Plaza Hotel St. Louis Chesterfield

14. Holiday Inn St. Louis West Six Flags by IHG

15. Residence Inn by Marriott St. Louis Chesterfield

16. DoubleTree by Hilton Hotel St. Louis - Chesterfield

17. Comfort Inn Near Six Flags St. Louis

18. Quality Inn Near Six Flags St. Louis

19. Hampton Inn St. Louis Wentzville

20. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Historic Daniel Boone Home and Heritage Center

Sugar Creek Winery

Yellow Farmhouse Winery

Broemmelsiek Park

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Ameristar Casino Resort and Spa

Drury Plaza Hotel St. Louis Creve Coeur

Drury Inn & Suites Southwest St. Louis

Drury Plaza Hotel St. Louis Chesterfield

The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Country Inn & Suites by Radisson, St. Charles Historic District

Wingate by Wyndham St. Louis/Fenton Route 66

More cheap stays in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

Quality Inn Foristell

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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