Offer Car Hire Car Hire in Southwest Illinois
Photo by Southernmost Illinois Tourism Bureau
Change your mindPenalty-free cancellation on many/select car hire
Treat yourselfMembers save 10% or more on over 1 million car hire
Shop smartCompare car suppliers to unlock big savings
Explore a world of travel with Expedia
- O'fallon Hotels
- 3 Star Hotels in Odin
- Freeburg Hotels
- Lebanon Hotels
- 5 Star Hotels in O'Fallon
- La Quinta Inn & Suites Hotels in Mascoutah
- Best Western Hotels in Baldwin
- Best Western Hotels in O'Fallon
- Sparta Hotels
- Spa Hotel Hotels in Carlyle
- Motel 6 Hotels in Carlyle
- Marissa Hotels
- Hotels near Salem Fairgrounds
- Mount Vernon Hotels
- Cheap Hotels in Belleville
- Drury Inn & Suites Hotels in New Baden
- Hilton Hotels in Swansea
- Cabin Rentals in Dix
- Hotels near O'Fallon Family Sports Park
- Casino Hotel Hotels in Southern Illinois
- 3 Star Hotels in New Athens
- Extended Stay America Hotels in Carlyle
- Pet-Friendly Hotel Hotels in Pocahontas
- Independent Hotels in Centralia
- Motels in Highland
- Hotels near World's Largest Catsup Bottle
- Cheap Hotels in Du Quoin
- Cabin Rentals in Waltonville
- B&B in O'Fallon
- Hyatt Hotels in Scott Air Force Base
- Troy Hotels
- Independent Hotels in Sparta
- B&B in Highland
- 5 Star Hotels in Hecker
- Golf Hotel Hotels in Sparta
- 3 Star Hotels in Bremen
- Apartments in Carlyle
- New Athens Hotels
- Pet-Friendly Hotel Hotels in Mount Vernon
- Highland Hotels
- Carlyle Hotels
- Red Roof Inn Hotels in Swansea
- Cheap Hotels in O'Fallon
- Pet-Friendly Hotel Hotels in Belleville
- Belleville Hotels
- Sesser Hotels
- Red Lion Hotels in Southwest Illinois
- Wyndham Hotels in New Baden
- Drury Inn & Suites Hotels in Highland
- 3 Star Hotels in Keyesport
- Pet-Friendly Hotel Hotels in O'Fallon
- Collinsville Hotels
- Bar Hotel Hotels in O'Fallon
- Hotel with Pool Hotels in O'Fallon
- Dix Hotels
- Nashville Hotels
- 5 Star Hotels in Marissa
- Hotels near Scott Air Force Base
- Hotel with Pool Hotels in Carlyle
- Hotels near Copper Dock Winery
- Cabin Rentals in Southern Illinois
- Drury Inn & Suites Hotels in Shiloh
- Luxury Hotel Hotels in Southern Illinois
- Guest Houses in Southwest Illinois
- Hotels near Shiloh-Scott Station
- 3 Star Hotels in Du Quoin
- 4 Star Hotels in Tamaroa
- Ava Hotels
- Hotels near William Jennings Bryan Boyhood Home and Museum
- 3 Star Hotels in Aviston
- Pet-Friendly Hotel Hotels in Carlyle
- Drury Inn & Suites Hotels in New Athens
- Vacation Homes in Belleville
- Hotels near Memorial Hospital Station
- Hotels near West Access Marina
- Apartments in Pocahontas
- Historic Hotel Hotels in Caseyville
- Farmstay in Southwest Illinois
- Cabin Rentals in Freeburg
- Apartments in Pinckneyville
Heading to Southwest Illinois? Explore Southwest Illinois with Expedia's Travel Guides to find the best hotels, holiday packages, car hire deals and more!