Byron Oxbow Nature Center Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Oxbow Nature Center hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

A modern hotel room with a bed, desk, and kitchenette.

A modern lounge area with a sofa, chairs, and tables.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

16.7 km from Oxbow Nature Center

howard

HK$859

HK$989 total

includes taxes & fees

7 Nov - 8 Nov

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

2. Econo Lodge Mayo Clinic Area

18 km from Oxbow Nature Center

Ashley

HK$518

HK$597 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

14.4 km from Oxbow Nature Center

Brien

HK$910

HK$1,047 total

includes taxes & fees

6 Nov - 7 Nov

A modern dining area with high tables, chairs, and pendant lighting.

A swimming pool with a tiled deck, sun loungers, and a lifeguard chair.

A reception desk with a large digital screen displaying a cityscape and the word "happy."

A multi-story hotel with a modern design, featuring a prominent entrance with a covered area and a parking lot in front.

4. Hampton Inn & Suites Rochester-North

11.4 km from Oxbow Nature Center

Mark

HK$803

HK$925 total

includes taxes & fees

6 Nov - 7 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

5. EVEN Hotel Rochester - Mayo Clinic Area by IHG

15.3 km from Oxbow Nature Center

James

HK$862

HK$1,098 total

includes taxes & fees

6 Nov - 7 Nov

A spacious lobby with a reception desk, sofas, and a coffee table.

A hotel room with a large bed, a sofa, a TV, and a desk.

A lobby with a brown sofa, yellow armchairs, a coffee table, and a clock on the wall.

A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

6. Sleep Inn & Suites West-Near Medical Center

11.3 km from Oxbow Nature Center

Jacqueline

HK$616

HK$709 total

includes taxes & fees

15 Nov - 16 Nov

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A modern dining area with wooden tables and chairs, a kitchen with granite countertops, and a view of the outdoors through large windows.

A hotel room with a blue sofa, a wooden coffee table, a bed with white linens, a TV, and a large mirror.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

7. Comfort Inn & Suites West - Medical Center

11.4 km from Oxbow Nature Center

Tammy

HK$680

HK$782 total

includes taxes & fees

15 Nov - 16 Nov

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A coffee station with two espresso machines and a variety of coffee pods and cups.

A hotel lobby with leather armchairs, a fireplace, patterned carpet, and a dining area in the background.

8. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

14.8 km from Oxbow Nature Center

Janet

HK$792

HK$911 total

includes taxes & fees

7 Nov - 8 Nov

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

9. Quality Inn & Suites Mayo Clinic Area

17.8 km from Oxbow Nature Center

Jessica

HK$534

HK$623 total

includes taxes & fees

13 Nov - 14 Nov

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A conference room with a long table, multiple chairs, and decorative wall art.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

15 km from Oxbow Nature Center

MATTHEW

HK$812

HK$934 total

includes taxes & fees

6 Nov - 7 Nov

A hotel room with a flat-screen TV, a sofa with a red pillow, a small table, and a lamp.

A hotel reception area with a coffee station, seating area, and a fireplace.

A hotel reception area with a red 'Hello' sign, a reception desk, a coffee station, and a fireplace.

A hotel room with a large bed, two bedside tables with lamps, a telephone, and a window with sheer curtains.

11. TownePlace Suites by Marriott Rochester

11.6 km from Oxbow Nature Center

Kari

HK$768

HK$884 total

includes taxes & fees

30 Oct - 31 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A modern bar area with a long counter, bar stools, and a television screen mounted on the wall.

A modern urban street with tall buildings, a pedestrian walkway, and a parking area.

12. Staybridge Suites Rochester - Mayo Clinic Area by IHG

15.3 km from Oxbow Nature Center

Amanda

HK$893

HK$1,044 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A gym with exercise equipment, a clock, and a window with blinds.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

13. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

15 km from Oxbow Nature Center

Lin

HK$920

HK$1,059 total

includes taxes & fees

24 Nov - 25 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

14. Hampton Inn Rochester-South

17.8 km from Oxbow Nature Center

dennis

HK$766

HK$882 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A restaurant interior with wooden tables, chairs, and a stone wall.

15. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

16.3 km from Oxbow Nature Center

Deanna

HK$895

HK$1,030 total

includes taxes & fees

31 Oct - 1 Nov

A modern hotel room with a dining area, a sofa, and a view of the landscape.

A rooftop terrace with outdoor seating and a city skyline in the background.

A modern indoor swimming pool with clear water, surrounded by lounge chairs and a seating area with a patterned wall.

16. Hilton Rochester Mayo Clinic Area

16.4 km from Oxbow Nature Center

Jennifer

HK$1,392

HK$1,603 total

includes taxes & fees

7 Nov - 8 Nov

A multi-story hotel with a stone facade, a central entrance, and a parking lot.

An outdoor patio with a stone wall, a grill, and seating.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

A hotel room with a dining area, a sofa, a TV, and a bed.

17. Candlewood Suites Rochester Mayo Clinic Area by IHG

17.7 km from Oxbow Nature Center

Kevin

HK$839

HK$965 total

includes taxes & fees

15 Nov - 16 Nov

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A bar with wooden stools and a neon sign.

18. AmericInn by Wyndham Rochester Near Mayo Clinic

17.6 km from Oxbow Nature Center

blake

HK$591

HK$681 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a wooden ceiling, clear blue water, and seating areas around the pool.

A lobby with two patterned armchairs, a wooden coffee table, a wall-mounted TV, a lamp, and a framed artwork.

A vending area with a beverage dispenser, a trash bin, and a water cooler.

A hotel room with two beds, a desk, a chair, a television, and a lamp.

19. Med City Inn & Suites - Mayo Clinic Area

14.6 km from Oxbow Nature Center

Chase

HK$592

HK$682 total

includes taxes & fees

25 Oct - 26 Oct

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

20. The Berkman

15 km from Oxbow Nature Center

Suzette

HK$1,491

HK$1,733 total

includes taxes & fees

21 Nov - 22 Nov

View all properties

Compare popular hotels close to Oxbow Nature Center

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Econo Lodge Mayo Clinic Area	9.0 Wonderful 1,009 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 748 reviews	View
Hampton Inn & Suites Rochester-North	9.2 Wonderful 1,000 reviews	View
EVEN Hotel Rochester - Mayo Clinic Area by IHG	9.4 Exceptional 1,002 reviews	View

Hotels recommended for families near Oxbow Nature Center

A modern kitchen with dark wood cabinets, stainless steel appliances, and a central island with seating.

An outdoor patio area with stone walls, outdoor seating, and landscaped gardens.

A compact hotel room with a kitchenette, a dining area, a seating area with a sofa and armchairs, and a large window with curtains.

A self-service breakfast area with a refrigerator, beverage dispenser, and a glass display case.

Staybridge Suites Rochester - Commerce Dr NW by IHG

Rochester

HK$909

HK$1,047 total

includes taxes & fees

7 Nov - 8 Nov

A modern kitchen with dark wooden cabinets, a central island with bar stools, and pendant lighting.

A modern two-story house with a garage, a covered driveway, and a well-maintained lawn.

A carpeted staircase with a handrail on the left and a railing on the right.

A kitchen with a modern design, featuring a black countertop, wooden cabinets, and a backsplash with a geometric pattern. There are two pendant lights above the sink.

Custom Luxury Rambler in Highland Hills, Rochester

Rochester

HK$2,728

HK$4,186 total

includes taxes & fees

25 Oct - 26 Oct

A spacious living area with a wooden dining table, bar stools, and a patterned armchair. A staircase leads to an upper level with a balcony.

A restaurant with a staircase, dining tables, chairs, a coffee machine, and a refrigerator.

An indoor swimming pool with a wooden ceiling and large windows.

Quality Inn near Medical Center

Rochester

HK$493

HK$567 total

includes taxes & fees

12 Nov - 13 Nov

Comfort Inn & Suites West - Medical Center

Rochester

HK$680

HK$782 total

includes taxes & fees

15 Nov - 16 Nov

Sleep Inn & Suites West-Near Medical Center

Rochester

HK$616

HK$709 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A compact hotel room with a kitchenette, a dining area, a sofa, and a bed.

A hotel room with a large window, a clock, a framed picture of pottery, a desk with a computer, and a seating area with patterned chairs.

A Microtel Inn & Suites building with a signboard, a parking lot, and a clear sky.

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

HK$546

HK$629 total

includes taxes & fees

1 Nov - 2 Nov

TownePlace Suites by Marriott Rochester

Rochester

HK$768

HK$884 total

includes taxes & fees

30 Oct - 31 Oct

A multi-story hotel with a brick facade, a covered lobby entrance, and a parking lot with several cars.

A compact kitchen with white cabinets, a microwave, a refrigerator, a sink, and a chair.

A hotel reception area with a black reception desk, a 'WELCOME' sign, a bench, and two armchairs.

Extended Stay America Suites Rochester North

Rochester

HK$501

HK$576 total

includes taxes & fees

30 Oct - 31 Oct

Top Oxbow Nature Center Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Convenient"

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"The hotel was very nice and convenient for travel to the Mayo Clinic with direct access to the underground walk way. The room was clean and nice to have the continental breakfast option. Construction was taking place outside of the hotel to improve the Mayo Clinic buildings in the area. The windows seemed to be rather low on their sound proofing ability. Almost seemed like the windows were open at times."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Close to Mayo with hourly shuttle service. Also parking underground was secure. Good breakfast included and the bar/restaurant very nice too. We will stay here again when my husband gets his other shoulder done."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Nice stay"

TownePlace Suites by Marriott Rochester

10/10 Excellent

"This is my go to hotel when visiting Rochester! Perfect for families, lots of room space and breakfast is always hot and fresh. Highly recommend!"

Kahler Grand Hotel

10/10 Excellent

"My fourth hotel in the area, and one of the best. Great old hotel vibe. Hot tub and pool on the roof. Perfect location if fast Mayo appointments are on your itinerary. Two very different eating options inside the hotel. I will be Back"

Sleep Inn & Suites West-Near Medical Center

8/10 Good

"The breakfast didn't have fruit or cut up fruit in frig. Did't care for the sausage"

Comfort Inn & Suites West - Medical Center

8/10 Good

"The room was very clean and the beds were comfortable. Breakfast was good with lots of options."

Extended Stay America Suites Rochester North

10/10 Excellent

"Me gustó que todo está muy limpio y la recepción fueron muy amables . Lo que no me gustó fue el desayuno , lo único que tenía fue café , pan y avena"

Other attractions near Oxbow Nature Center

Zollman Zoo

Visit the native and exotic animals who call Zollman Zoo home during your travels in Byron. Amble around the area's parks or experience its art scene.

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Oxbow Park

8.8/10 (5 reviews)

Explore the great outdoors at Oxbow Park, a lovely green space in Byron. Visit the cosy cafes or top-notch restaurants in this walkable area.

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Kalmar Town Hall

Kalmar Town Hall is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

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Putting Green

Enjoy a round of golf in Byron at Putting Green. Amble around the area's parks or experience its art scene.

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Somerby Golf Club

Enjoy a round of golf in Byron at Somerby Golf Club. Amble around the area's parks or experience its art scene.

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East Brookfield Park

After visiting East Brookfield Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Somerby Park

Somerby Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.

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Brook Lawn Park

After visiting Brook Lawn Park, make a plan to see the other sights and activities in Byron. Amble around the area's parks or experience its art scene.

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Frequently asked questions

What's the area like around Oxbow Nature Center?

Oxbow Nature Center is located in Byron. You'll find 7 hotels and other accommodations within a few miles for a convenient home base.

What's the best place to stay close to Oxbow Nature Center?

Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. You'll find it 10.1 mi (16.2 km) from Oxbow Nature Center. Other good choices around the area include AmericInn by Wyndham Rochester Near Mayo Clinic and Quality Inn near Medical Center.

How many hotels will I find near Oxbow Nature Center?

Expedia has 7 hotels and other accommodation options a few miles from Oxbow Nature Center.

If I need to cancel the hotel reservation for my stay near Oxbow Nature Center, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available near Oxbow Nature Center.

What can I see and do near Oxbow Nature Center?

If you're looking forward to a day of shopping, consider Byron Town Square, Cheery Meadows Center and High Point Shopping Center and pick out the perfect souvenir. Putting Green, Somerby Golf Club and Links of Byron Mini Golf are worth a stop while you're in the area. Oxbow Park, Zollman Zoo and Kalmar Town Hall are a few additional nearby sights.

Byron Oxbow Nature Center Hotels

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Oxbow Nature Center hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Econo Lodge Mayo Clinic Area

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

4. Hampton Inn & Suites Rochester-North

5. EVEN Hotel Rochester - Mayo Clinic Area by IHG

6. Sleep Inn & Suites West-Near Medical Center

7. Comfort Inn & Suites West - Medical Center

8. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

9. Quality Inn & Suites Mayo Clinic Area

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11. TownePlace Suites by Marriott Rochester

12. Staybridge Suites Rochester - Mayo Clinic Area by IHG

13. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

14. Hampton Inn Rochester-South

15. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

16. Hilton Rochester Mayo Clinic Area

17. Candlewood Suites Rochester Mayo Clinic Area by IHG

18. AmericInn by Wyndham Rochester Near Mayo Clinic

19. Med City Inn & Suites - Mayo Clinic Area

20. The Berkman

Compare popular hotels close to Oxbow Nature Center

Hotels recommended for families near Oxbow Nature Center

Staybridge Suites Rochester - Commerce Dr NW by IHG

Custom Luxury Rambler in Highland Hills, Rochester

Quality Inn near Medical Center

Comfort Inn & Suites West - Medical Center

Sleep Inn & Suites West-Near Medical Center

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

TownePlace Suites by Marriott Rochester

Extended Stay America Suites Rochester North

Top Oxbow Nature Center Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Kahler Inn and Suites - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Hyatt House Rochester/Mayo Clinic Area

TownePlace Suites by Marriott Rochester

Kahler Grand Hotel

Sleep Inn & Suites West-Near Medical Center

Comfort Inn & Suites West - Medical Center

Extended Stay America Suites Rochester North

Other attractions near Oxbow Nature Center

Zollman Zoo

Oxbow Park

Kalmar Town Hall

Putting Green

Somerby Golf Club

East Brookfield Park

Somerby Park

Brook Lawn Park

Frequently asked questions