Photo by Bill Dillard

Southeast Missouri hotels from HK$402
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Our top choices for Southeast Missouri hotels

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (223 reviews)
The price is HK$1,153
HK$1,220 total
includes taxes & fees
5 Mar - 6 Mar

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,010 reviews)
The price is HK$625
HK$661 total
includes taxes & fees
1 Mar - 2 Mar

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (53 reviews)
The price is HK$539
HK$917 total
includes taxes & fees
25 Feb - 26 Feb

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (511 reviews)
The price is HK$685
HK$773 total
includes taxes & fees
8 Mar - 9 Mar

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (560 reviews)
The price is HK$713
HK$816 total
includes taxes & fees
26 Feb - 27 Feb

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (587 reviews)
The price is HK$724
HK$824 total
includes taxes & fees
2 Mar - 3 Mar

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (159 reviews)
The price is HK$727
HK$820 total
includes taxes & fees
5 Mar - 6 Mar

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (710 reviews)
The price is HK$658
HK$712 total
includes taxes & fees
1 Mar - 2 Mar

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (996 reviews)
The price is HK$734
HK$830 total
includes taxes & fees
1 Mar - 2 Mar

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (493 reviews)
The price is HK$535
HK$608 total
includes taxes & fees
25 Feb - 26 Feb

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,008 reviews)
The price is HK$781
HK$882 total
includes taxes & fees
1 Mar - 2 Mar

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,007 reviews)
The price is HK$734
HK$844 total
includes taxes & fees
1 Mar - 2 Mar

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (111 reviews)
The price is HK$763
HK$868 total
includes taxes & fees
2 Mar - 3 Mar

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (801 reviews)
The price is HK$737
HK$825 total
includes taxes & fees
8 Mar - 9 Mar

Hampton Inn By Hilton Dexter
Hampton Inn By Hilton DexterDexter
10.0 out of 10, Exceptional, (12 reviews)
The price is HK$827
HK$928 total
includes taxes & fees
5 Mar - 6 Mar

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (338 reviews)
The price is HK$703
HK$762 total
includes taxes & fees
15 Mar - 16 Mar

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (60 reviews)
The price is HK$860
HK$973 total
includes taxes & fees
5 Mar - 6 Mar

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (447 reviews)
The price is HK$681
HK$772 total
includes taxes & fees
1 Mar - 2 Mar

Days Inn & Suites By Wyndham Festus
Days Inn & Suites By Wyndham FestusFestus
The price is HK$738
HK$844 total
includes taxes & fees
1 Mar - 2 Mar

Arcadia Academy
Arcadia AcademyArcadia
9.8 out of 10, Exceptional, (11 reviews)
The price is HK$1,064
HK$1,154 total
includes taxes & fees
26 Feb - 27 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (53 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Photo by Bill Dillard
Open Photo by Bill Dillard
More cheap stays in Southeast Missouri

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is HK$381 per night from 26 Feb to 27 Feb
HK$381
HK$402 total
26 Feb - 27 Feb
includes taxes & fees
8/10 Very Good! (1,007 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
2 properties
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