Photo by Bill Dillard

Southeast Missouri hotels from HK$424

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Our top choices for Southeast Missouri hotels

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is HK$665
HK$757 total
includes taxes & fees
22 Dec - 23 Dec
The Farmstead Hotel

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1002)
"Love the updated rooms and the vending area."
United States
Kathi
The price is HK$591
HK$624 total
includes taxes & fees
22 Dec - 23 Dec
Motel 6 Poplar Bluff, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1007)
"Great place and staff, very accommodating!"
United States
Megan
The price is HK$700
HK$790 total
includes taxes & fees
28 Dec - 29 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is HK$739
HK$834 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is HK$807
HK$912 total
includes taxes & fees
9 Jan - 10 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
"Great place "
United States
GUY
The price is HK$655
HK$709 total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1005)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is HK$574
HK$654 total
includes taxes & fees
24 Dec - 25 Dec
Best Western Plus Sikeston

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1006)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is HK$646
HK$683 total
includes taxes & fees
22 Dec - 23 Dec
Drury Inn & Suites Jackson MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (720)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is HK$432
HK$492 total
includes taxes & fees
22 Dec - 23 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (332)
"Staff was very friendly."
United States
Joyce
The price is HK$742
HK$805 total
includes taxes & fees
23 Dec - 24 Dec
Honeysuckle Inn - Mountain View

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is HK$545
HK$614 total
includes taxes & fees
28 Dec - 29 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (449)
"Friendly staff clean rooms "
United States
Christopher
The price is HK$759
HK$860 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston

Town House Inn

Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (425)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is HK$503
HK$545 total
includes taxes & fees
21 Jan - 22 Jan 2026
Town House Inn

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is HK$724
HK$819 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (888)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is HK$721
HK$824 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
"Staff was great! Room was nice. "
United States
Lana
The price is HK$483
HK$536 total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Charleston/Sikeston East MO

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (911)
"Vary clean"
United States
George
The price is HK$589
HK$688 total
includes taxes & fees
24 Dec - 25 Dec
Comfort Inn Festus - St Louis South

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1005)
"Clean room, great location and friendly staff"
United States
Mark
The price is HK$700
HK$805 total
includes taxes & fees
26 Dec - 27 Dec
Drury Inn & Suites Sikeston, MO

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is HK$877
HK$982 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn Poplar Bluff

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (730)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southeast Missouri

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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

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