Photo by Bill Dillard
Southeast Missouri hotels from HK$424
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Our top choices for Southeast Missouri hotels
8.8 out of 10, Excellent, (463)
"Nice place "
Debbie
The price is HK$665
HK$757 total
includes taxes & fees
22 Dec - 23 Dec
7.8 out of 10, Good, (1002)
"Love the updated rooms and the vending area."
Kathi
The price is HK$591
HK$624 total
includes taxes & fees
22 Dec - 23 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1007)
"Great place and staff, very accommodating!"
Megan
The price is HK$700
HK$790 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian
The price is HK$739
HK$834 total
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
Teresa
The price is HK$807
HK$912 total
includes taxes & fees
9 Jan - 10 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
8.8 out of 10, Excellent, (672)
"Great place "
GUY
The price is HK$655
HK$709 total
includes taxes & fees
7 Jan - 8 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Holiday Home
10.0 out of 10, Exceptional, (3)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is HK$411 per night from 27 Dec to 28 Dec
HK$411
HK$468 total
27 Dec - 28 Dec
includes taxes & fees
7.8/10 Good! (1,003 reviews)
Hotels in Southeast Missouri with star-rating
4 Star Hotels
2 properties
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