Photo by Southernmost Illinois Tourism Bureau
Southern Illinois hotels from HK$418
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Family friendly
Check prices for these dates
Our top choices for Southern Illinois hotels
Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
9.6 out of 10, Exceptional, (1,704 reviews)
"A nice stay"
DAVID
The price is HK$1,011
HK$1,138 total
includes taxes & fees
4 Jul - 5 Jul
Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
9.0 out of 10, Wonderful, (1,003 reviews)
"Super close to mid America airport. Great breakfast and they had complimentary chili in the evening."
Scot
The price is HK$928
HK$1,057 total
includes taxes & fees
22 Jun - 23 Jun
Cobblestone Inn & Suites - Altamont
Cobblestone Inn & Suites - AltamontAltamont
9.6 out of 10, Exceptional, (878 reviews)
"The hotel was fabulous!"
Dominic
The price is HK$776
HK$838 total
includes taxes & fees
12 Jul - 13 Jul
Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
9.0 out of 10, Wonderful, (1,048 reviews)
"Quick and easy check in, fruendly staff, bed and pillows were super comfy and the breakfast was great. "
Todd
The price is HK$933
HK$1,051 total
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
9.0 out of 10, Wonderful, (1,002 reviews)
"Clean room, friendly staff, ver attentive and thoughtful at breakfast."
Melissa
The price is HK$925
HK$1,042 total
includes taxes & fees
5 Jul - 6 Jul
Quality Inn & Suites Metropolis I-24
Quality Inn & Suites Metropolis I-24Metropolis
7.8 out of 10, Good, (1,002 reviews)
"Excellent stay and conveniently located. Staff was very helpful during my 3 day stay"
Howard
The price is HK$541
HK$624 total
includes taxes & fees
21 Jun - 22 Jun
Baymont by Wyndham Effingham
Baymont by Wyndham EffinghamEffingham
8.2 out of 10, Very good, (1,003 reviews)
"Very clean, good breakfast"
Rickey
The price is HK$633
HK$702 total
includes taxes & fees
27 Jun - 28 Jun
Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
9.6 out of 10, Exceptional, (742 reviews)
"Everything about this place was excellent"
Andrew
The price is HK$970
HK$1,077 total
includes taxes & fees
4 Jul - 5 Jul
Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
8.8 out of 10, Excellent, (1,001 reviews)
"Wonderful stay. "
Jennifer
The price is HK$749
HK$831 total
includes taxes & fees
28 Jun - 29 Jun
Super 8 by Wyndham Troy IL/St. Louis Area
Super 8 by Wyndham Troy IL/St. Louis AreaTroy
8.0 out of 10, Very good, (1,003 reviews)
"Good customer service well put together hotel"
Donta
The price is HK$564
HK$626 total
includes taxes & fees
22 Jun - 23 Jun
Best Western Delta Inn
Best Western Delta InnEffingham
9.0 out of 10, Wonderful, (1,002 reviews)
"Nice quick stay"
Bri
The price is HK$773
HK$865 total
includes taxes & fees
21 Jun - 22 Jun
Suite Dreams Hotel
Suite Dreams HotelMattoon
8.8 out of 10, Excellent, (3 reviews)
"Owners are very nice and take pride in their hotel and it shows!"
Judd
The price is HK$745
HK$834 total
includes taxes & fees
23 Jun - 24 Jun
La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
9.2 out of 10, Wonderful, (1,002 reviews)
"Clean hotel, excellent staff, good breakfast"
Alexis
The price is HK$839
HK$940 total
includes taxes & fees
28 Jun - 29 Jun
Quality Inn Effingham North
Quality Inn Effingham NorthEffingham
8.4 out of 10, Very good, (1,002 reviews)
"Nice overnight stay"
Suzanne
The price is HK$683
HK$758 total
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Express & Suites Vandalia by IHG
Holiday Inn Express & Suites Vandalia by IHGVandalia
8.8 out of 10, Excellent, (832 reviews)
"Easy access fro I70.. Hotel very full but breakfast dining was clean & stocked."
Joyce
The price is HK$846
HK$922 total
includes taxes & fees
28 Jun - 29 Jun
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Quality Inn & Suites Vandalia near I-70 and Hwy 51Vandalia
8.4 out of 10, Very good, (1,002 reviews)
"Place was great. Not to bad for a great place to crash after a day of fishing."
Dawn
The price is HK$558
HK$609 total
includes taxes & fees
23 Jun - 24 Jun
Baymont by Wyndham Chester IL
Baymont by Wyndham Chester ILChester
8.6 out of 10, Excellent, (398 reviews)
"Nice place"
Doug
The price is HK$585
HK$650 total
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Effingham by IHG
Holiday Inn Effingham by IHGEffingham
9.2 out of 10, Wonderful, (692 reviews)
"Nice hotel. Great location on the Ohio River. Walking distance to the old downtown."
Glenn
The price is HK$792
HK$886 total
includes taxes & fees
3 Jul - 4 Jul
The Principal Hotel
The Principal HotelColumbia
9.6 out of 10, Exceptional, (302 reviews)
"Great hotel and nice staff!"
Michelle
The price is HK$884
HK$981 total
includes taxes & fees
22 Jun - 23 Jun
Days Inn & Suites by Wyndham Casey
Days Inn & Suites by Wyndham CaseyCasey
7.6 out of 10, Good, (886 reviews)
"Clean room and great staff!"
Beth
The price is HK$522
HK$579 total
includes taxes & fees
19 Jul - 20 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews
Comfort Inn Edwardsville - St. Louis
8/10 Good
More cheap stays in Southern Illinois
Welcome Suites
148 Regency Park O'Fallon IL
The price is HK$364 per night from 23 Jun to 24 Jun
HK$364
HK$418 total
23 Jun - 24 Jun
includes taxes & fees
Hotels in Southern Illinois with star-rating
4 Star Hotels
3 properties
Explore a world of travel with Expedia
- Pet-Friendly Hotel Hotels in Mount Vernon
- Motels in Albion
- Dix Hotels
- Hotels near Rend Lake College
- 5 Star Hotels in Corinth
- 3 Star Hotels in Aviston
- Motels in Herrin
- Makanda Hotels
- Mulberry Grove Hotels
- Motel 6 Hotels in Carlyle
- Extended Stay America Hotels in Carlyle
- Casino Hotel Hotels in Southern Illinois
- Farmstay in Southwest Illinois
- Golf Hotel Hotels in Sparta
- Cabin Rentals in Waltonville
- Cabin Rentals in Marion
- Albion Hotels
- Cisne Hotels
- Mount Vernon Hotels
- Guest Houses in Southwest Illinois
- Hamilton County Hotels
- Cabin Rentals in Dix
- Romantic Hotel Hotels in Carterville
- 3 Star Hotels in Keyesport
- 4 Star Hotels in Sims
- Cheap Hotels in Du Quoin
- Hotels near William Jennings Bryan Statue
- Red Roof Inn Hotels in Carbondale
- Cabin Rentals in Christopher
- Marissa Hotels
- Hotel with Pool Hotels in Carlyle
- Goreville Hotels
- Kinmundy Hotels
- Spa Hotel Hotels in Carlyle
- Apartments in Carlyle
- Carlyle Hotels
- 4 Star Hotels in Tamaroa
- Ava Hotels
- Sesser Hotels
- Creal Springs Hotels
- Hilton Hotels in Ewing
- Noble Hotels
- Hotels near William Jennings Bryan Boyhood Home and Museum
- Sparta Hotels
- Family Hotel Hotels in Grayville
- Red Lion Hotels in Southwest Illinois
- Hotels near West Access Marina
- Hotels near Stone Creek Golf Club and Resort
- Family Hotel Hotels in Harrisburg
- 3 Star Hotels in Odin
- 4 Star Hotels in Carmi
- Drury Inn & Suites Hotels in New Baden
- Hotels near Flora City Hall
- Pet-Friendly Hotel Hotels in Marion
- Lodges in Whittington
- Hotels near Mount Vernon Outland
- Apartments in Pinckneyville
- Fairfield Hotels
- Lodges in Enfield
- Adventure Sport Hotel Hotels in Marion
- Luxury Hotel Hotels in Southern Illinois
- Cabin Rentals in Southern Illinois
- La Quinta Inn & Suites Hotels in Southern Illinois
- Pet-Friendly Hotel Hotels in Carlyle
- Marion Hotels
- Chalets in Southern Illinois
- Hotels near Kokopelli Golf Club
- Cheap Hotels in Carbondale
- Cabin Rentals in Carbondale
- B&B in Southern Illinois
- Independent Hotels in Sparta
- 3 Star Hotels in Du Quoin
- 4 Star Hotels in Carbondale
- Hotels near Southern Illinois
- Ina Hotels
- Nashville Hotels
- Independent Hotels in Centralia
- Hotels near Salem Fairgrounds
- Cheap Hotels in Grayville
- Lodges in Herrin
- 3 Star Hotels in Carmi
