Best Southwest Illinois Hotels in 2026 from HK$390 - Fully Refundable Options

A calm lake surrounded by trees and vegetation.

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Go beyond your typical stay in Southwest Illinois

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Our top choices for Southwest Illinois hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

HK$870

HK$981 total

includes taxes & fees

13 Sept - 14 Sept

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

A Best Western U.S. Inn with a modern design, featuring a covered entrance and a parking lot.

A reception area with a stone wall, a round mirror, a reception desk, and a computer setup.

A hotel room with two beds, a desk, and a window with a view.

2. Best Western U. S. Inn

Nashville

James

HK$941

HK$1,025 total

includes taxes & fees

10 Sept - 11 Sept

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

A spacious lobby with a modern design, featuring a large seating area with leather chairs, a kitchen area with a counter and appliances, and a flat-screen TV mounted on the wall.

A hotel room with a large bed, a desk with a chair, a sofa, and a TV.

A modern hotel room with a living area, a kitchenette, and a door leading to another room.

3. Best Western Plus MidAmerica Hotel

Mascoutah

Justin

HK$824

HK$939 total

includes taxes & fees

30 Aug - 31 Aug

A hotel room with two beds, a desk with a computer, a chair, a TV, and two wall-mounted lamps.

A conference room with a TV, a door, and a window with blinds.

A reception area with a counter, framed certificates, a clock, and a checkered floor.

A bathroom with a granite countertop sink, a mirror, a towel rack, and a telephone.

4. Super 8 by Wyndham Okawville

Okawville

Peter

HK$520

HK$551 total

includes taxes & fees

6 Sept - 7 Sept

A hotel room with two beds, a large window, and a wall-mounted lamp.

A Holiday Inn Express & Suites building with a parking lot and a covered entrance.

An indoor swimming pool with a 4'2" depth, tiled walls, and a ceiling with recessed lighting.

A hotel reception area with two reception desks, a wall-mounted digital screen, and a security camera.

5. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Abigail

HK$894

HK$1,007 total

includes taxes & fees

27 Sept - 28 Sept

A hotel lobby with a reception desk, seating area, and a large screen TV.

A hotel dining area with a large wooden table, red upholstered chairs, a flat-screen TV mounted above the fireplace, and a kitchen area in the background.

A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.

A Comfort Suites hotel with a spacious parking lot and a modern brick facade.

6. Comfort Suites Mount Vernon

Mount Vernon

Erica

HK$894

HK$1,007 total

includes taxes & fees

30 Aug - 31 Aug

A hotel room with a bed, a television, a desk, and a chair.

A reception area with a reception desk, a computer, a sewing machine, and an exit sign.

A breakfast area with a counter, microwave, coffee machine, and seating.

7. Super 8 by Wyndham Greenville

Greenville

Rebecca

HK$508

HK$564 total

includes taxes & fees

7 Sept - 8 Sept

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

A hotel reception area with a computer desk, a printer, a coffee machine, and a framed cityscape picture on the wall.

A hotel reception area with a long wooden counter, coffee machines, and a wall with framed pictures.

8. Comfort Inn & Suites Greenville I-70

Greenville

Alan

HK$783

HK$869 total

includes taxes & fees

20 Sept - 21 Sept

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

A hotel lobby with a reception desk, a red sofa, a potted plant, and a fireplace.

A modern dining area with round tables and chairs, a green booth seating area, and artwork on the walls.

A hotel room with a large bathtub, a desk with a chair, and a bed.

9. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Blake

HK$858

HK$968 total

includes taxes & fees

11 Sept - 12 Sept

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

A gym with weightlifting equipment, treadmills, and a mirrored wall.

A reception area with a wooden reception desk, a wall-mounted decorative piece, and a vending machine.

A modern living room with a fireplace, comfortable seating, and a television.

10. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

HK$1,086

HK$1,249 total

includes taxes & fees

20 Sept - 21 Sept

An indoor swimming pool area with multiple lanes, lounge chairs, and a small seating area.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

A lobby with patterned sofas, a fireplace, and framed pictures on the wall.

A modern hotel lobby with seating areas, including sofas and chairs, and a large window with blinds.

11. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

KEVIN

HK$831

HK$964 total

includes taxes & fees

27 Sept - 28 Sept

A brick building with a wooden gazebo in front.

A spacious dining area with multiple round tables and chairs, a fireplace, and large windows with curtains.

A compact kitchen with a sink, microwave, and stove, a wooden cabinet, and a television mounted on the wall.

A hotel room with two beds, a dresser, a television, and a bathroom visible through an open door.

12. Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

les

HK$854

HK$982 total

includes taxes & fees

30 Aug - 31 Aug

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

A spacious lobby with a large seating area, a reception desk, and a television.

An indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls. There are lounge chairs and a small seating area with tables.

13. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

HK$1,090

HK$1,220 total

includes taxes & fees

7 Sept - 8 Sept

A hotel room with a large bed, a red bedspread, a bathtub, a nightstand with a lamp, and two framed pictures on the wall.

A kitchen with a dishwasher, coffee makers, a water dispenser, and various kitchen utensils.

A hotel room with a wooden dining table, four brown chairs, a beige sofa, a small wooden coffee table, a lamp, a framed picture on the wall, and a kitchenette with a microwave.

A hotel room with a sofa, two lamps, a television, and a desk.

14. Seasons Inn & Suites Highland

Highland

Patricia

HK$678

HK$753 total

includes taxes & fees

7 Sept - 8 Sept

A hotel room with two beds, a desk, a chair, and a wall-mounted lamp.

A Holiday Inn Express building with a modern design, featuring a covered entrance and a parking lot.

An indoor swimming pool with a lifeguard on duty sign, a pool lift, and chairs around the pool area.

A lobby with green armchairs, a sofa, a flat-screen TV, and framed artwork on the walls.

15. Holiday Inn Express Troy by IHG

Troy

Donald

HK$862

HK$957 total

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

A hotel room with two beds, a desk, a chair, a TV, and a balcony with a view.

A modern indoor seating area with leather chairs and tables, a central round table, and a staircase leading to an upper level.

A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.

16. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Samuel

HK$1,074

HK$1,208 total

includes taxes & fees

30 Aug - 31 Aug

A lobby with a wooden staircase, a desk with a computer, and patterned armchairs.

A gym with treadmills, elliptical machines, and weight equipment.

A Ramada hotel with a brick facade, large entrance, and a clear sky.

A kitchen with white cabinets, a microwave, a coffee machine, and a refrigerator.

17. Ramada by Wyndham Vandalia

Vandalia

Harold

HK$635

HK$692 total

includes taxes & fees

30 Aug - 31 Aug

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.

A hotel with a brick facade, a flagpole with an American flag, and a parking lot with several cars.

18. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Matthew W,

HK$550

HK$626 total

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

A hotel with a flat facade, multiple windows, and a sign indicating it is a 'SureStay Hotel by Best Western'.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.

19. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Vinay

HK$635

HK$705 total

includes taxes & fees

6 Sept - 7 Sept

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A gym with treadmills, a weight machine, and exercise balls.

A breakfast area with a counter, seating, and kitchen appliances.

A room with a fireplace, a mounted deer head, a bookshelf, and two armchairs.

20. Baymont by Wyndham Chester IL

Chester

Keng

HK$607

HK$673 total

includes taxes & fees

30 Aug - 31 Aug

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Stay near popular Southwest Illinois attractions

World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

See properties

O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Visit the shops and top-notch restaurants in this family-friendly area.

See properties

DuQuoin State Fairgrounds

8.2/10 (95 reviews)

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

See properties

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

See all hotels in Southwest Illinois

A swampy area with tall, thin trees and water reflecting the sky.

Top Southwest Illinois Hotel Reviews

Super 8 by Wyndham Collinsville St. Louis

10/10 Excellent

"It was a very clean and nice place to stay. Thank you again."

Drury Inn & Suites St. Louis Collinsville

10/10 Excellent

"Always a pleasant stay at the Drury Inn!"

Baymont by Wyndham Marion

10/10 Excellent

"Nice rooms and beds. Good shower and water pressure. Good AC!"

The Principal Hotel

10/10 Excellent

"The Principal has become our favorite hotel we stay at! Clean- really nice rooms! anything you could want for food or drink within walking distance- and the on-site restaraunt -Graphite is awesome if you are lookig for fine dining plus they give you a discount when staying! The town of Columbia is great!"

Comfort Inn Edwardsville - St. Louis

10/10 Excellent

"Free parking, quiet and close to the freeway"

Super 8 by Wyndham O'Fallon

10/10 Excellent

"My stay was good and my room was clean"

DoubleTree by Hilton Mt. Vernon

10/10 Excellent

"What a beautiful place to stay! Our room was spacious and clean. Breakfast was fantastic!"

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent

"Great value- Clean room - Amazing staff- Surprisingly good breakfast - Plenty of surrounding food options"

Motel 6 Caseyville, IL - Caseyville Il

10/10 Excellent

"Great place to stay it was clean and staff was helpful!"

More cheap stays in Southwest Illinois

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

HK$433

HK$498 total

21 Sept - 22 Sept

includes taxes & fees

6.6/10 (1,083 reviews)

Comfort Suites Fairview Heights - St. Louis

137 Ludwig Dr Fairview Heights IL

HK$593

HK$670 total

20 Sept - 21 Sept

includes taxes & fees

Best Western St. Louis Fairview Heights

150 Ludwig Dr Fairview Heights IL

HK$626

HK$708 total

31 Aug - 1 Sept

includes taxes & fees

Baymont by Wyndham Marion

2608 W Main St Marion IL

HK$642

HK$770 total

1 Sept - 2 Sept

includes taxes & fees

8.4/10 Very good! (1,091 reviews)

Comfort Suites Mount Vernon

404 South 44th Street Mount Vernon IL

HK$894

HK$1,007 total

30 Aug - 31 Aug

includes taxes & fees

Best Western U. S. Inn

11640 State Route 127 Nashville IL

HK$941

HK$1,025 total

10 Sept - 11 Sept

includes taxes & fees

Hotels in Southwest Illinois with star-rating

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Southwest Illinois hotels from HK$390

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southwest Illinois

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southwest Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

2. Best Western U. S. Inn

3. Best Western Plus MidAmerica Hotel

4. Super 8 by Wyndham Okawville

5. Holiday Inn Express & Suites Mount Vernon by IHG

6. Comfort Suites Mount Vernon

7. Super 8 by Wyndham Greenville

8. Comfort Inn & Suites Greenville I-70

9. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

10. Fairfield Inn & Suites by Marriott O'Fallon, IL

11. Drury Inn & Suites St. Louis O'Fallon, IL

12. Country Hearth Inn & Suites Edwardsville St. Louis

13. Best Western Plus Centralia Hotel & Suites

14. Seasons Inn & Suites Highland

15. Holiday Inn Express Troy by IHG

16. DoubleTree by Hilton Mt. Vernon

17. Ramada by Wyndham Vandalia

18. Super 8 by Wyndham Mt. Vernon IL

19. SureStay Hotel by Best Western Whittington Rend Lake

20. Baymont by Wyndham Chester IL

Stay near popular Southwest Illinois attractions

World Wide Technology Raceway

O'Fallon Family Sports Park

DuQuoin State Fairgrounds

Learn more about Southwest Illinois

Top Southwest Illinois Hotel Reviews

Super 8 by Wyndham Collinsville St. Louis

Drury Inn & Suites St. Louis Collinsville

Baymont by Wyndham Marion

The Principal Hotel

Comfort Inn Edwardsville - St. Louis

Super 8 by Wyndham O'Fallon

DoubleTree by Hilton Mt. Vernon

Quality Inn O'Fallon - St. Louis - Shiloh

Motel 6 Caseyville, IL - Caseyville Il

More cheap stays in Southwest Illinois

Super 8 by Wyndham O'Fallon

Comfort Suites Fairview Heights - St. Louis

Best Western St. Louis Fairview Heights

Baymont by Wyndham Marion

Comfort Suites Mount Vernon

Best Western U. S. Inn

Hotels in Southwest Illinois with star-rating

Explore a world of travel with Expedia

Go further with the Expedia app