Southeast Missouri 5 Stars Hotels
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Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Southeast Missouri.

Urban Lofts
104 North Jackson Street, Perryville, MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews
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Southeast Missouri Star Rating Hotels
Southeast Missouri Hotels Near an Attraction
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Echo Bluff State Park
- Hotels near Current River State Park
- Hotels near Taum Sauk Mountain State Park
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Hotels near K Bridge Recreation Area
- Hotels near Hawn State Park
Southeast Missouri Theme Hotels
- Adults Only in Southeast Missouri
- Adventure Sport Hotel in Southeast Missouri
- Bar Hotel in Southeast Missouri
- Business Hotel in Southeast Missouri
- Casino Hotel in Southeast Missouri
- Cheap Hotels in Southeast Missouri
- Family Hotel in Southeast Missouri
- Golf Hotel in Southeast Missouri
- Historic Hotel in Southeast Missouri
- Hotel with Pool in Southeast Missouri
- Luxury Hotel in Southeast Missouri
- Pet-friendly Hotel in Southeast Missouri
- Romantic Hotel in Southeast Missouri
- Ski Hotel in Southeast Missouri
- Spa Hotel in Southeast Missouri
- Wedding Hotels in Southeast Missouri
- Winery Hotel in Southeast Missouri
More accommodation types in Southeast Missouri
- Vacation Homes in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- Cottages in Southeast Missouri
- Apartments in Southeast Missouri
- Motels in Southeast Missouri
- Farmstay in Southeast Missouri
- RV Parks in Southeast Missouri
- Lodges in Southeast Missouri
- Aparthotels in Southeast Missouri
- Condo Rentals in Southeast Missouri
- B&B in Southeast Missouri
- Villas in Southeast Missouri
Explore more hotels
- Pear Tree Inn Sikeston
- Drury Inn & Suites Sikeston, MO
- Super 8 by Wyndham Farmington
- Drury Inn & Suites Jackson MO
- Best Western Plus Sikeston
- Courtyard by Marriott Cape Girardeau Downtown
- Silo Farm Haus- located in the heart of wine country!
- Drury Inn & Suites Cape Girardeau
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Days Inn and Suites by Wyndham Sikeston
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Postcard Cabins St. Francois
- Hampton Inn Poplar Bluff
- Super 8 by Wyndham Perryville
- Quality Inn
- Super 8 by Wyndham Bonne Terre
- Hampton Inn Sikeston
- Holiday Inn Express & Suites Perryville by IHG
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