Santa Fe Lake

A waterfront with Spanish moss-covered trees, a wooden dock, and a distant shoreline.

Top Santa Fe Lake Hotel Deals

3 Bedroom House on Private Scenic Lake Mable

3 Bedroom House on Private Scenic Lake Mable

Melrose FL
3 Bedroom House on Private Scenic Lake Mable
Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites

2.5 out of 5
17230 Ne Us Highway 301 Waldo FL
Best Western Waldo Inn and Suites
Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG

2.5 out of 5
15111 S.Highway 301 Starke FL
Holiday Inn Express Starke by IHG
Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida

3 out of 5
1514 Southwest 14th Street Gainesville FL
Hotel Eleo at the University of Florida
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

3 out of 5
4000 Southwest 40th Blvd Gainesville FL
Drury Inn & Suites Gainesville
Gainesville Lodge

Gainesville Lodge

2 out of 5
413 West University Ave Gainesville FL
Gainesville Lodge
Hampton Inn & Suites Gainesville Downtown University

Hampton Inn & Suites Gainesville Downtown University

3 out of 5
101 SE 1st Ave Gainesville FL
Hampton Inn & Suites Gainesville Downtown University
Red Carpet Inn

Red Carpet Inn

2 out of 5
744 N Temple Ave Starke FL
Red Carpet Inn
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2.5 out of 5
2603 SW 13TH STREET Gainesville FL
Comfort Suites Gainesville near University
See all 1,380 properties in Santa Fe Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.