Sioux Falls Sioux Empire Medical Museum Hotels

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Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Sioux Empire Medical Museum hotels

Interior detail
Hotel On Phillips

Hotel On Phillips

2.5 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1293)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (584)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is HK$803
HK$897 total
includes taxes & fees
20 Dec - 21 Dec
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

3.0 star property
Mall District, 2.8 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1000)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

4.0 star property
Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (152)
"Room was very clean, great overall stay."
United States
Destiny
The price is HK$1,078
HK$1,229 total
includes taxes & fees
23 Dec - 24 Dec
Canopy By Hilton Sioux Falls Downtown
Front of property – evening/night
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1003)
"Great location and a friendly staff "
United States
Dan
The price is HK$760
HK$849 total
includes taxes & fees
19 Dec - 20 Dec
Hampton Inn Sioux Falls
Living area
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

3.0 star property
Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum
9.0 out of 10, Wonderful, (881)
"Under construction but staff adapted and accommodated very well. Room was clean and quiet. Perfect location "
United States
Joseph
The price is HK$852
HK$981 total
includes taxes & fees
29 Dec - 30 Dec
Hilton Garden Inn Sioux Falls Downtown
Porch
Historic Victorian Inn

Historic Victorian Inn

3.0 star property
Cathedral, 1.5 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is HK$977
HK$1,199 total
includes taxes & fees
18 Dec - 19 Dec
Historic Victorian Inn
Exterior
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1000)
"Breakfast good, staff very accommodating and friendly. "
United States
Geraldine
The price is HK$1,011
HK$1,125 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

3.0 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1004)
"Always a great stay. "
United States
Shawn
The price is HK$739
HK$978 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Sioux Falls-City Centre by IHG
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

4.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1000)
"Great hotel. Staff was excellent "
United States
Kristina
The price is HK$754
HK$843 total
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Sioux Falls Hotel & Convention Center
Exterior
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

3.0 star property
Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum
8.4 out of 10, Very good, (1153)
"It was a great place to stay!"
United States
Trinity
The price is HK$754
HK$843 total
includes taxes & fees
29 Dec - 30 Dec
Country Inn & Suites by Radisson, Sioux Falls, SD
Free daily continental breakfast
The Center Inn

The Center Inn

2.5 star property
All Saints, 2.4 km from Sioux Empire Medical Museum
8.4 out of 10, Very good, (699)
"Clean room and friendly staff."
United States
Betty
The Center Inn
3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
7.8 out of 10, Good, (1451)
"Everything was wonderful: Airport shuttle, room, breakfast, waterpark area, staff. What a great stay!"
United States
Christine
The price is HK$466
HK$526 total
includes taxes & fees
18 Dec - 19 Dec
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

2.5 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
7.6 out of 10, Good, (1003)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

2.0 star property
Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum
7.0 out of 10, Good, (51)
"Great "
United States
Jorge
Ramada by Wyndham Sioux Falls Arpt & Suites
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

2.0 star property
2.6 km from Sioux Empire Medical Museum
5.6 out of 10, (1007)
"Good room for the price."
United States
Michael
The price is HK$370
HK$422 total
includes taxes & fees
24 Dec - 25 Dec
Ramada by Wyndham Sioux Falls
Front of property
WoodSpring Suites Sioux Falls

WoodSpring Suites Sioux Falls

2.5 star property
2.8 km from Sioux Empire Medical Museum
5.2 out of 10, (60)
"The price was good, the cleanliness was better than other cheap hotels I've stayed in. My primary complaint was the slow internet speeds. There was also damage that had not been repaired from prior guests."
United States
Trent
The price is HK$537
HK$604 total
includes taxes & fees
10 Dec - 11 Dec
WoodSpring Suites Sioux Falls
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

3.0 star property
1.4 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveller
The price is HK$2,094
HK$2,374 total
includes taxes & fees
14 Dec - 15 Dec
Historic Twin Tudors Inn
In-room safe, desk, laptop workspace, blackout curtains
Highpoint Hotel

Highpoint Hotel

3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
The price is HK$1,309
HK$1,452 total
includes taxes & fees
16 Dec - 17 Dec
Highpoint Hotel
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

3.0 star property
Mall District, 3.7 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1002)
"Great location for travel. Various dining options close by."
United States
Russell
The price is HK$938
HK$1,045 total
includes taxes & fees
24 Dec - 25 Dec
Hyatt Place Sioux Falls South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sioux Empire Medical Museum Hotel Reviews

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

10/10 Excellent
"YES"
David 1-night trip
Posted 19 hours ago
Hampton Inn Sioux Falls

Hotels near other Sioux Empire Medical Museum attractions

Great Plains Zoo

4.3/5 (74 reviews)
Why not meet the animals who live at Great Plains Zoo during your holiday in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
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University of Sioux Falls

4.1/5 (170 reviews)
Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?
Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 108 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Sioux Empire Medical Museum?
Adjacent to Sioux Empire Medical Museum, Valley Inn is one of the top choices for your stay based on our traveller data, and this hotel offers free parking and free WiFi. Another good choice is Home2 Suites By Hilton Sioux Falls/Sanford Medical Center, located just 0.1 mi (0.2 km) away.
How many hotels are there close to Sioux Empire Medical Museum?
Expedia has 108 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.
If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.
What can I see and do near Sioux Empire Medical Museum?
Washington Pavilion of Arts and Science, Center for Western Studies and Delbridge Museum of Natural History feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can wander around Falls Park, Sherman Park or Veterans' Memorial Park if you want a dose of fresh air.

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