Best Southern Illinois Hotels in 2026 from HK$470 - Fully Refundable Options

A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Go beyond your typical stay in Southern Illinois

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Our top choices for Southern Illinois hotels

Desk, blackout curtains, iron/ironing board, free cots/infant beds

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

HK$871

HK$982 total

includes taxes & fees

6 Sept - 7 Sept

In-room safe, desk, laptop workspace, blackout curtains

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Angela D

HK$894

HK$1,008 total

includes taxes & fees

23 Aug - 24 Aug

In-room safe, desk, iron/ironing board, free cots/infant beds

3. Comfort Suites Mount Vernon

Mount Vernon

Erica

HK$923

HK$1,040 total

includes taxes & fees

16 Aug - 17 Aug

Pillow-top beds, in-room safe, desk, iron/ironing board

4. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Samuel

HK$1,003

HK$1,129 total

includes taxes & fees

3 Sept - 4 Sept

Desk, blackout curtains, iron/ironing board, free WiFi

5. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Matthew W,

HK$530

HK$604 total

includes taxes & fees

30 Aug - 31 Aug

Premium bedding, pillow-top beds, desk, laptop workspace

6. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Debbie

HK$628

HK$697 total

includes taxes & fees

13 Aug - 14 Aug

7. Quality Inn Mount Vernon, IL

Mount Vernon

David

HK$593

HK$674 total

includes taxes & fees

23 Aug - 24 Aug

Indoor pool, open 8 AM to 10 PM, pool loungers

8. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

HK$1,169

HK$1,309 total

includes taxes & fees

16 Aug - 17 Aug

9. Days Inn by Wyndham Mount Vernon

Mount Vernon

Norberto

HK$567

HK$645 total

includes taxes & fees

16 Aug - 17 Aug

10. Hampton Inn & Suites Effingham

Effingham

Kate

HK$959

HK$1,064 total

includes taxes & fees

7 Sept - 8 Sept

11. Drury Inn & Suites Marion

Marion

Alicia

HK$832

HK$998 total

includes taxes & fees

16 Aug - 17 Aug

Premium bedding, down duvets, desk, blackout curtains

12. Holiday Inn Express & Suites Effingham by IHG

Effingham

Sheridan

HK$910

HK$1,019 total

includes taxes & fees

23 Aug - 24 Aug

Premium bedding, in-room safe, desk, laptop workspace

13. Comfort Inn & Suites Marion I-57

Marion

Daniel

HK$894

HK$1,073 total

includes taxes & fees

16 Aug - 17 Aug

Desk, laptop workspace, blackout curtains, iron/ironing board

14. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

HK$807

HK$904 total

includes taxes & fees

23 Aug - 24 Aug

Desk, laptop workspace, iron/ironing board, free WiFi

15. Best Western U. S. Inn

Nashville

James

HK$941

HK$1,026 total

includes taxes & fees

16 Aug - 17 Aug

16. Cobblestone Inn & Suites - Altamont

Altamont

Daria

HK$777

HK$839 total

includes taxes & fees

13 Aug - 14 Aug

Indoor pool, open 7:00 AM to noon, pool loungers

17. Holiday Inn Effingham by IHG

Effingham

Parry

HK$792

HK$887 total

includes taxes & fees

31 Aug - 1 Sept

Pillow-top beds, desk, laptop workspace, blackout curtains

18. Best Western Plus MidAmerica Hotel

Mascoutah

Jaysen

HK$859

HK$980 total

includes taxes & fees

20 Aug - 21 Aug

In-room safe, desk, blackout curtains, soundproofing

19. Holiday Inn Express & Suites Salem by IHG

Salem

Todd

HK$894

HK$1,002 total

includes taxes & fees

30 Aug - 31 Aug

20. Baymont by Wyndham Marion

Marion

james

HK$692

HK$830 total

includes taxes & fees

16 Aug - 17 Aug

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Holiday Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.

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World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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Harrah's Metropolis

8.0/10 (310 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Would recommend this hotel."

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent

"Very, very clean and the staff was very, very helpful"

Best Western St. Louis Fairview Heights

8/10 Good

"The one thing I did not like was the lack of a soft drink machine or a snack machine without going to another hotel."

Drury Inn & Suites Marion

10/10 Excellent

"The room was clean, the staff was very friendly. Pool and hot tub was clean and nice. The breakfast, dinner and drinks were good. Love the afternoon popcorn as well."

The Principal Hotel

10/10 Excellent

"E"

Baymont by Wyndham Effingham

8/10 Good

"The king room 103 was outdated but clean. Toilet seat was loose. TV could have used a written channel guide. Bed was so comfortable! Fairly quiet. Breakfast was good and hot. Would recommend for a quick overnight stop on the road."

Holiday Inn Express Metropolis by IHG

10/10 Excellent

"Great stop over hotel. Comfy beds and comfy rooms. Clean and well Maintained for an older hotel building that has been refurbished."

Baymont by Wyndham Marion

10/10 Excellent

"It was clean, quiet, and good parking."

Comfort Suites Fairview Heights - St. Louis

8/10 Good

"Service was good. Rooms were as expected for the price. However, one room had a bad smell that I think was coming from the tub. Swimming pool was not good. Very cloudy water and smelled of algae. Overall not bad for the price."

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

HK$417

HK$479 total

13 Aug - 14 Aug

includes taxes & fees