Best Southern Illinois Hotels in 2026 from HK$460 - Fully Refundable Options

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Our top choices for Southern Illinois hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

HK$870

HK$982 total

includes taxes & fees

20 Sept - 21 Sept

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.

A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.

A hotel room with two beds, a large window, and a wall-mounted lamp.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

John

HK$925

HK$1,043 total

includes taxes & fees

27 Sept - 28 Sept

A hotel lobby with a reception desk, seating area, and a large screen TV.

A brick building with a patio area featuring wicker furniture and a table.

A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.

A hotel dining area with a large wooden table, red upholstered chairs, a flat-screen TV mounted above the fireplace, and a kitchen area in the background.

3. Comfort Suites Mount Vernon

Mount Vernon

James

HK$931

HK$1,049 total

includes taxes & fees

4 Oct - 5 Oct

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

A modern indoor seating area with leather chairs and tables, a central round table, and a staircase leading to an upper level.

A hotel room with two beds, a desk, a chair, a TV, and a balcony with a view.

A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.

4. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Samuel

HK$1,003

HK$1,129 total

includes taxes & fees

1 Oct - 2 Oct

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

A reception area with a desk, chairs, a red carpet, and a television mounted on the wall.

A hotel with a covered entrance, multiple rooms, and a parking lot.

A hotel room with two beds, a nightstand, a lamp, and a framed picture on the wall.

5. Quality Inn Mount Vernon, IL

Mount Vernon

Matthew

HK$593

HK$674 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A parking lot with a Super 8 sign, a white car, and a truck.

A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.

A reception area with a counter, a clock, and a chandelier.

6. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Matthew W,

HK$572

HK$651 total

includes taxes & fees

15 Sept - 16 Sept

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

A hallway with vending machines and a carpeted floor.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.

7. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

MARK

HK$635

HK$705 total

includes taxes & fees

20 Sept - 21 Sept

A small, clean room with a microwave, a vending machine, and a table with chairs.

A reception area with a wooden counter, a tiled floor, and a wall with framed pictures.

A self-service laundry station with multiple washing machines, a price tag of $1.50, and a sign indicating guest services at the lobby.

A hotel room with two beds, a desk, a TV, and a bathroom door.

8. Rodeway Inn Mount Vernon, IL

Mount Vernon

Emil

HK$533

HK$608 total

includes taxes & fees

15 Sept - 16 Sept

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

A hotel lobby with a large indoor pool, a reception desk, and a seating area.

A modern living area with a sectional sofa, a fireplace, and a flat-screen TV.

A treats section with a variety of snacks and beverages, including a refrigerated display and shelves stocked with items like Welch's and Bonde.

9. Hampton Inn & Suites Effingham

Effingham

Kate

HK$894

HK$992 total

includes taxes & fees

20 Sept - 21 Sept

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

An indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls. There are lounge chairs and a small seating area with tables.

A spacious lobby with a large seating area, a reception desk, and a television.

10. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

HK$1,090

HK$1,221 total

includes taxes & fees

17 Sept - 18 Sept

An indoor swimming pool with a diving board, a changing room, and a tiled floor.

A hotel room with two beds, a desk, a window with curtains, and a painting on the wall.

A restaurant with a tiled floor, wooden tables and chairs, a counter with a coffee machine, and a tiled backsplash.

A Days Inn building with a flat roof, large windows, and a sign above the entrance.

11. Days Inn by Wyndham Mount Vernon

Mount Vernon

Asa

HK$567

HK$645 total

includes taxes & fees

20 Sept - 21 Sept

A modern hotel room with a large bed, a desk with a computer, a chair, a large window, a bathroom with a bathtub, and a green accent wall.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A hotel room with a large window, a blue sofa, a patterned armchair, a desk, and a television.

A grocery store aisle with shelves stocked with various food items and two refrigerated beverage dispensers.

12. Holiday Inn Express & Suites Effingham by IHG

Effingham

Sheridan

HK$941

HK$1,054 total

includes taxes & fees

18 Sept - 19 Sept

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

An indoor swimming pool with clear water, tiled walls, and a ceiling with square vents.

An outdoor patio area with a table and chairs, a red umbrella, and a brick building facade.

13. Drury Inn & Suites Marion

Marion

Suzanne

HK$737

HK$884 total

includes taxes & fees

20 Sept - 21 Sept

A Country Inn & Suites building with a covered entrance and a sign.

A building with a green roof, white columns, and a glass entrance.

A restaurant with wooden tables and chairs, a coffee bar with various appliances, and a TV mounted on the wall.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a no diving sign.

14. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Larry

HK$742

HK$824 total

includes taxes & fees

20 Sept - 21 Sept

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

A modern kitchen area with a counter, various appliances, and food display items.

A hotel room with a large bed, a desk with a chair, a flat-screen TV, a bathtub, and framed pictures on the wall.

15. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

HK$900

HK$1,008 total

includes taxes & fees

20 Sept - 21 Sept

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and landscaped gardens.

A golf course with a flagstick, trees, and a water hazard.

A modern kitchen with a central island, bar stools, and various appliances.

A spacious lobby with a reception desk, seating area, and a kitchen in the background.

16. Comfort Inn & Suites Marion I-57

Marion

Daniel

HK$847

HK$1,016 total

includes taxes & fees

4 Oct - 5 Oct

A banquet hall with tables set for a formal event, draped with white fabric and string lights, and a chandelier above.

A spacious restaurant with high ceilings, large windows, and a variety of seating arrangements including tables and chairs.

A Holiday Inn lobby with a reception desk, two armchairs, and a decorative ceiling light.

A bar area with a long counter, multiple stools, and a television screen.

17. Holiday Inn Effingham by IHG

Effingham

Penny

HK$823

HK$922 total

includes taxes & fees

24 Sept - 25 Sept

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a framed artwork on the wall.

A Best Western hotel with a modern facade, a parking lot, and a clear sky.

A hotel room with a desk, two monitors, a keyboard, and a mouse.

18. Best Western Delta Inn

Effingham

Chris

HK$678

HK$759 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a bed, a desk, a television, and a bathroom.

A reception area with a stone wall, a reception desk, and a red patterned chair.

A hotel room with a kitchenette, a dining area, a sofa, a bed, and a patterned carpet.

An indoor swimming pool with clear blue water, wooden beams, and brick walls.

19. Quality Inn Effingham North

Effingham

Sierra

HK$602

HK$669 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor seating area with a fire pit, surrounded by wooden chairs and a view of a sunset over a landscaped garden.

A hotel room with a large bed, a wooden headboard, a nightstand, a desk, a chair, and a painting on the wall.

A modern bathroom with a grey cabinet, two lamps, a round mirror, and an elevator.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

20. Best Western Plus Parkside Inn & Suites

Olney

Richard

HK$993

HK$1,102 total

includes taxes & fees

20 Sept - 21 Sept

View all properties

Holiday Rentals in Southern Illinois

Cottage

A covered porch with blue plastic chairs, a ceiling fan, and large windows offering a view of the outdoors.

A single-story house with a stone foundation and a gabled roof, surrounded by a small lawn and a wooden fence.

A bedroom with a bed, a nightstand, a mirror, a ceiling fan, and a door leading to a bathroom.

A kitchen with wooden cabinets, a microwave, a dishwasher, and a dining area with chairs and a table.

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

A modern kitchen with dark cabinets, a round dining table, and a tufted bench.

A modern living room with a flat-screen TV, wooden entertainment unit, leather sofa, and a dining table.

A bedroom with a bed, a chair, a window, and two framed pictures on the wall.

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Cottage

A living room with a fireplace, leather sofas, and a clock on the wall.

A room with a wooden wall, a window with a view of a deck and outdoor area, and a potted plant with flowers on a table.

A bedroom with a bed, wooden walls, a welcome sign, a television, and a door.

A modern kitchen with wooden cabinets, a white refrigerator, and a microwave. There is a dining area with a table and chairs, and a living room with a couch and a fireplace.

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

A long, narrow hallway with wooden floors and large windows.

A modern kitchen with a stainless steel refrigerator, oven, and dishwasher. There is a wooden dining table and a brick accent wall.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a tiled floor.

A covered porch with wooden flooring, a bench, and large windows.

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

A modern kitchen with white cabinetry, a coffee maker, a sink, a dishwasher, and a built-in oven.

A hallway with a white door, a mirror, a lamp, and a basket on a console table.

A modern kitchen with white cabinets, a wooden dining table, and black chairs.

A living room with a beige sectional sofa, a wooden coffee table, a patterned rug, and a small side table with a lamp.

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.

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Harrah's Metropolis

8.0/10 (310 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Ramada by Wyndham Effingham

10/10 Excellent

"Everything was great and great location and great breakfast."

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"We were meeting up with family for the weekend. Hotel staff went out of their way to keep us together. Rooms were clean and bed comfortable."

Country Inn & Suites by Radisson, Effingham, IL

8/10 Good

"Close to the interstate."

Baymont by Wyndham Effingham

10/10 Excellent

"Rooms are clean, external and internal building clean, staff awesome, the man at the front desk morning shift super guy. Breakfast options good, best so far among the budget hotels have being to. Parking, sufficient spaces even for large commercial trucks and there is Petro behind the hotel and a restaurant right beside."

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"The amenities where excellent and offered more then other places offer. The staff were kind d and friendly. The rooms where clean, comfortable, and up to what you wa t feom a hotel stay.I would stay there again."

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

10/10 Excellent

"I enjoyed my stay at Harrahs. The hotel was nice and clean. The staff was friendly and helpful. I ordered room service food from the grill which arrived quickly and tasted fresh. The only thing I was wondering was why The Bridges didn't have room service. I did go to Bridges for breakfast and it tasted fresh and flavorful. I enjoyed the casino with had a good selection of slots, but I would stay there even without gaming. I enjoyed it very much."

Motel 6 Caseyville, IL - Caseyville Il

8/10 Good

"Average"

Comfort Inn Edwardsville - St. Louis

10/10 Excellent

"A very nice place to stay. Breakfast was amazing."

Comfort Suites Fairview Heights - St. Louis

8/10 Good

"There was a smell in our room that was very strong. Other than that it was clean."

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

HK$400

HK$460 total

20 Sept - 21 Sept

includes taxes & fees

Americas Best Value Inn Collinsville St. Louis

552 Ramada Blvd Collinsville IL

HK$413

HK$475 total

11 Oct - 12 Oct

includes taxes & fees

Best Western Delta Inn

1509 Hampton Dr Effingham IL

HK$678

HK$759 total

20 Sept - 21 Sept

includes taxes & fees

9/10 Wonderful! (1,002 reviews)

Country Inn & Suites by Radisson, Effingham, IL

1200 N Raney Effingham IL

HK$742

HK$824 total

20 Sept - 21 Sept

includes taxes & fees

8.8/10 Excellent! (1,004 reviews)

Comfort Inn Edwardsville - St. Louis

3080 S State Route 157 Edwardsville IL

HK$720

HK$828 total

21 Sept - 22 Sept

includes taxes & fees

8.4/10 Very good! (936 reviews)

Baymont by Wyndham Marion

2608 W Main St Marion IL

HK$708

HK$849 total

20 Sept - 21 Sept

includes taxes & fees

Southern Illinois hotels from HK$460

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southern Illinois

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

2. Holiday Inn Express & Suites Mount Vernon by IHG

3. Comfort Suites Mount Vernon

4. DoubleTree by Hilton Mt. Vernon

5. Quality Inn Mount Vernon, IL

6. Super 8 by Wyndham Mt. Vernon IL

7. SureStay Hotel by Best Western Whittington Rend Lake

8. Rodeway Inn Mount Vernon, IL

9. Hampton Inn & Suites Effingham

10. Best Western Plus Centralia Hotel & Suites

11. Days Inn by Wyndham Mount Vernon

12. Holiday Inn Express & Suites Effingham by IHG

13. Drury Inn & Suites Marion

14. Country Inn & Suites by Radisson, Effingham, IL

15. La Quinta Inn & Suites by Wyndham Effingham

16. Comfort Inn & Suites Marion I-57

17. Holiday Inn Effingham by IHG

18. Best Western Delta Inn

19. Quality Inn Effingham North

20. Best Western Plus Parkside Inn & Suites

Holiday Rentals in Southern Illinois

Harrisburg Home w/ Private Yard + Screened Porch!

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Illinois Vacation Rental Home: Pets Welcome

Cozy Anna Home Near Southern Illinois Attractions!

Country Home Near EIU & Lake Charleston!

Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

World Wide Technology Raceway

O'Fallon Family Sports Park

Harrah's Metropolis

Learn more about Southern Illinois

Top Southern Illinois Hotel Reviews

Ramada by Wyndham Effingham

Drury Plaza Hotel Mt. Vernon

Country Inn & Suites by Radisson, Effingham, IL

Baymont by Wyndham Effingham

Drury Inn & Suites St. Louis Fairview Heights

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Motel 6 Caseyville, IL - Caseyville Il

Comfort Inn Edwardsville - St. Louis

Comfort Suites Fairview Heights - St. Louis

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

Americas Best Value Inn Collinsville St. Louis

Best Western Delta Inn

Country Inn & Suites by Radisson, Effingham, IL

Comfort Inn Edwardsville - St. Louis

Baymont by Wyndham Marion

Hotels in Southern Illinois with star-rating

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