A modern building with a unique triangular roof and a central spire.

Santa Lucia hotels in Syracuse

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
31 Jul - 2 Aug
Next weekend
7 Aug - 9 Aug

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Lucia hotels

Rooftop terrace

1. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (289 reviews)
"Beautiful hotel with good amenities"
Canada
Alessia
The price is HK$1,410
HK$1,640 total
includes taxes & fees
29 Jul - 30 Jul
Caportigia Boutique Hotel
Front of property

2. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (686 reviews)
"This accommodation was very comfortable and I would highly recommend it."
Australia
Janet
The price is HK$1,386
HK$1,580 total
includes taxes & fees
12 Aug - 13 Aug
Grande Albergo Alfeo
Breakfast area

3. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (130 reviews)
"Amazing stay. Beautiful views and everyone was very friendly. "
United States
Anna
The price is HK$2,293
HK$2,612 total
includes taxes & fees
30 Jul - 31 Jul
Giuggiulena Villa
Coffee/tea maker, electric kettle

4. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (282 reviews)
The price is HK$778
HK$887 total
includes taxes & fees
29 Jul - 30 Jul
Nostos rooms & Apartments
Porch

5. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (386 reviews)
"This was my favorite stay in Sicily! I love the elevator and the staff were really nice and accommodating. I also want to point out the excellent AC inside the room. I would only suggest a bottle of water inside the room and a personal tea/ coffee station."
United States
Diane
The price is HK$759
HK$865 total
includes taxes & fees
4 Aug - 5 Aug
Piccolo Hotel Casa Mia
Minibar, in-room safe, desk, soundproofing

6. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (74 reviews)
"The room appeared to be recently remodeled and was very modern. Of the 4 hotels that we stayed at on this trip, the bed/pillows were the most comfortable. Great view of the marina from our room balcony and public parking (free) was relatively easy. "
United States
Michael
The price is HK$885
HK$1,009 total
includes taxes & fees
29 Jul - 30 Jul
Lakkios
View from room

7. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (15 reviews)
"Clean, very convenient for exploring Ortigia. Nice continental breakfast."
United States
Mary
The price is HK$1,417
HK$1,616 total
includes taxes & fees
3 Aug - 4 Aug
Calafatari B&B
Balcony

8. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (88 reviews)
"."
United States
Dany
The price is HK$712
HK$812 total
includes taxes & fees
2 Aug - 3 Aug
B&B Nike
1 bedroom, down duvets, minibar, in-room safe

9. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (58 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
The price is HK$1,955
HK$2,239 total
includes taxes & fees
29 Jul - 30 Jul
Re Dionisio Luxury Suites
In-room safe, desk, soundproofing, iron/ironing board

10. B&B IL MORO

B&B IL MORO
Santa Lucia
The price is HK$706
HK$1,008 total
includes taxes & fees
30 Jul - 31 Jul
B&B IL MORO
Desk, soundproofing, iron/ironing board (on request), free WiFi

11. B&B Vergilia

B&B Vergilia
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (56 reviews)
"The host, Raymond is very friendly. He came to meet us at the Square and explained in details on every houseware."
Canada
Siu-Fai
The price is HK$912
HK$1,040 total
includes taxes & fees
29 Jul - 30 Jul
B&B Vergilia
Lobby lounge

12. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (17 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is HK$880
HK$1,004 total
includes taxes & fees
2 Aug - 3 Aug
Regina Margherita
Soundproofing, free WiFi

13. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (43 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
The price is HK$988
HK$1,126 total
includes taxes & fees
3 Aug - 4 Aug
Hotel Palazzo Cavalieri
Terrace/patio

14. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (36 reviews)
"Wonderful stay in the center of it all "
United States
lori
The price is HK$1,475
HK$1,682 total
includes taxes & fees
29 Jul - 30 Jul
Fortaleza Charme House
In-room safe, desk, soundproofing, iron/ironing board

15. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.0 out of 10, Very good, (2 reviews)
"Great hotel. Close to everything 15min walk into Ortigia and the excursions dock. The staff are incredibly helpful and thoughtful. Rooms are clean and nice. The balcony had great views of the water and ortigia. Highly recommend to anyone visiting Siracusa! "
United States
Aria
The price is HK$2,087
HK$2,384 total
includes taxes & fees
29 Jul - 30 Jul
Casa Miranda Boutique
Premium bedding, down duvets, memory-foam beds, in-room safe

16. Eos Sea View Apartment

Eos Sea View Apartment
Santa Lucia
10.0 out of 10, Exceptional, (2 reviews)
The price is HK$1,174
HK$1,339 total
includes taxes & fees
1 Aug - 2 Aug
Eos Sea View Apartment
Free daily buffet breakfast

17. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
9.4 out of 10, Exceptional, (9 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is HK$1,050
HK$1,197 total
includes taxes & fees
6 Aug - 7 Aug
San Nicola Rooms Siracusa
Premium bedding, desk, cots/infant beds, rollaway beds

18. B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (60 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is HK$729
HK$832 total
includes taxes & fees
4 Aug - 5 Aug
B&B Siracusa
View from room

19. Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (124 reviews)
"Very friendly and helpful staff."
United States
David
The price is HK$739
HK$843 total
includes taxes & fees
30 Jul - 31 Jul
Hotel Mediterraneo
View from room

20. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (42 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is HK$656
HK$748 total
includes taxes & fees
27 Aug - 28 Aug
Gymnasium
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Lucia

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Breakfast area
Giuggiulena Villa
3.0 star property
10.0
Exceptional
130 reviews
View
Minibar, in-room safe, desk, soundproofing
Lakkios
3.0 star property
9.2
Wonderful
74 reviews
View
Rooftop terrace
Caportigia Boutique Hotel
5.0 star property
9.4
Exceptional
289 reviews
View
Soundproofing, free WiFi
Hotel Palazzo Cavalieri
4.0 star property
9.0
Wonderful
43 reviews
View
Porch
Piccolo Hotel Casa Mia
3.0 star property
8.6
Excellent
386 reviews
View

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

A natural rock arch over a body of water with people paddling in kayaks.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

Top Santa Lucia Hotel Reviews

Mangia's Brucoli, Sicily, Autograph Collection

Mangia's Brucoli, Sicily, Autograph Collection

10/10 Excellent
"We stayed here for 5 nights in a room with private pool. The room was of high standards, clean and elegant, and the pool and outdoor area perfect for relaxing in privacy. The property in general was beautiful and well maintained. Food was good and the breakfast buffet left little to wish for. The offer of paying €120 pp per day for lunch and dinner is not worth it, though, even though the restaurants are quite expensive. Overall a very nice stay and we highly recommend this hotel."
Therese 5-night trip
Posted 7 hours ago
Mangia's Brucoli, Sicily, Autograph Collection

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Lucia?
Based on our traveller data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Caportigia Boutique Hotel and Fortaleza Charme House.
How many hotels will I find in Santa Lucia?
Expedia has 312 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia