Best Santee Hotels in 2026 from HK$509 - Fully Refundable Options

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Our top choices for Santee hotels

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

1. Hampton Inn Santee-I-95

Santee

Janice

HK$977

HK$1,084 total

includes taxes & fees

20 Sept - 21 Sept

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

2. Fairfield Inn & Suites by Marriott Santee

Santee

Melissa

HK$1,052

HK$1,167 total

includes taxes & fees

20 Sept - 21 Sept

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

3. Tru By Hilton Santee

Santee

Vicky L

HK$765

HK$849 total

includes taxes & fees

27 Sept - 28 Sept

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

4. Best Western Plus Santee Inn

Santee

Bonnie

HK$867

HK$962 total

includes taxes & fees

20 Sept - 21 Sept

A water park with a pool, slides, and umbrellas.

A modern lounge area with seating, tables, and a fireplace.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

5. Holiday Inn Santee by IHG

Santee

Dennis

HK$823

HK$914 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

6. Baymont by Wyndham Santee

Santee

Yomerys

HK$627

HK$696 total

includes taxes & fees

13 Sept - 14 Sept

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

7. Comfort Inn & Suites Santee

Santee

santa

HK$812

HK$901 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

8. Travelodge by Wyndham Santee

Santee

Mark

HK$502

HK$557 total

includes taxes & fees

27 Sept - 28 Sept

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

9. Quality Inn & Suites Santee I-95

Santee

Will

HK$452

HK$545 total

includes taxes & fees

17 Sept - 18 Sept

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

A two-story building with a beige facade, large windows, and a central entrance.

10. Super 8 by Wyndham Santee/I-95

Santee

William

HK$500

HK$555 total

includes taxes & fees

17 Sept - 18 Sept

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

11. Red Roof Inn Santee

Santee

Tiffany

HK$494

HK$548 total

includes taxes & fees

14 Sept - 15 Sept

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A bathroom with a sink, mirror, and a shower area.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

12. Econo Lodge Santee

Santee

Dorothy

HK$472

HK$524 total

includes taxes & fees

1 Oct - 2 Oct

A gym with treadmills, an elliptical, dumbbells, and a bench.

A hotel room with two beds, a desk, and a chair.

A conference room with round tables, black chairs, and white tablecloths.

13. Ramada by Wyndham Santee I-95

Santee

Stevenson

HK$560

HK$622 total

includes taxes & fees

27 Sept - 28 Sept

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A tent with two beds, a small table, and a chair.

A modern room with a grey sofa, a small table, and a view of a lake and parked car through large glass doors.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

14. Bells Marina & Resort

Eutawville

Amber

HK$643

HK$737 total

includes taxes & fees

13 Sept - 14 Sept

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.

A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

A corner market with a refrigerator stocked with beverages and snacks.

15. Fairfield Inn by Marriott Orangeburg

Orangeburg

Percy

HK$827

HK$917 total

includes taxes & fees

15 Sept - 16 Sept

A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

A hotel room with a large bed, bedside tables, a desk, and a chair.

A reception desk with a digital screen displaying 'Welcome' and 'Red Roof Inn.' There is a clock on the wall, a window with a view of a parking lot, and a refrigerator with 'Carolina's' branding.

A hotel reception area with a counter, coffee machines, and a refrigerator.

16. Red Roof Inn Orangeburg

Orangeburg

Amanda

HK$459

HK$509 total

includes taxes & fees

21 Sept - 22 Sept

A self-service kiosk with a beverage cooler, microwave, and various food items.

A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.

A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.

A modern interior with a dining area, seating arrangements, and a reception desk.

17. Tru by Hilton Orangeburg

Orangeburg

Andrew

HK$894

HK$992 total

includes taxes & fees

27 Sept - 28 Sept

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

A gym with treadmills, a bench, and a ball.

A modern dining area with tables and chairs, large windows with sheer curtains, and pendant lighting.

A snack shop with a sign reading "Hampton Suite Shop" and a variety of snacks and drinks on display.

18. Hampton Inn & Suites Orangeburg

Orangeburg

JORDAN

HK$1,022

HK$1,135 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a desk, a chair, and a mirror.

A two-story building with a sign indicating it is a hotel.

A wooden pergola with a bench, a well-maintained lawn, and a parking area with buildings in the background.

A living room with a sofa, armchair, coffee table, and a flat-screen TV mounted on the wall.

19. SureStay Hotel by Best Western Manning

Manning

Christopher

HK$642

HK$713 total

includes taxes & fees

23 Sept - 24 Sept

A spacious dining area with multiple tables and chairs, a reception desk, and large windows providing natural light.

A modern lobby with a wooden ceiling, a central seating area with a round table, and a bar with a variety of bottles.

An outdoor patio area with a fire pit, seating, and tables.

A modern hotel room with a grey sofa, a flat-screen TV, a desk with a lamp, and abstract wall art.

20. SpringHill Suites by Marriott Orangeburg

Orangeburg

Henrietta

HK$856

HK$950 total

includes taxes & fees

17 Sept - 18 Sept

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Stay near popular Santee attractions

Santee State Park

8.0/10 (219 reviews)

Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.

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Santee Cooper Country Club

7.8/10 (94 reviews)

This George Cobb-designed course winds through majestic pines with strategic doglegs and panoramic Lake Marion views. Enjoy the signature closing hole and well-maintained fairways perfect for golfers of all skill levels.

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Santee National Golf Club

8.0/10 (74 reviews)

This championship course blends Lowcountry charm with highland terrain, featuring moss-draped oaks and pristine bunkers. Enjoy diverse play with wide-open front nine and wooded back nine challenges.

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Santee Town Hall

Santee Town Hall serves as the community's administrative hub with rental spaces for local events. The grounds feature a charming gazebo and spacious lawn perfect for seasonal celebrations like the Easter Egg Hunt.

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Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

See all hotels in Santee

A tree with Spanish moss and autumn leaves in a body of water.

Top Santee Hotel Reviews

Holiday Inn Santee by IHG

10/10 Excellent

"Great value and amazing amenities. Hotel looks amazing, must have been redone recently."

Tru By Hilton Santee

10/10 Excellent

"Great place to stay!"

SureStay Hotel by Best Western Manning

10/10 Excellent

"Will be stopping there agaun"

Hampton Inn Santee-I-95

10/10 Excellent

"Every things was just right"

Baymont by Wyndham Santee

8/10 Good

"Clean room. Friendly staff"

Red Roof Inn Santee

10/10 Excellent

"Nice place. Clean & mattress was super comfy!"

Waterfront Lake Marion Retreat • Pool • Gazebo • Minutes from I-95

10/10 Excellent

"The condo was perfect. Clean, everything was very nice. Was pictured just like it was. Host was excellent for communication and easy check in! We will be back"

Travelodge by Wyndham Santee

10/10 Excellent

"Love the location very friendly and clean. I love they have high security on site"

Ramada by Wyndham Santee I-95

8/10 Good

"The price rate was great"

More cheap stays in Santee

Peach Tree Inn

111 Conners Dr St. George SC

HK$507

HK$547 total

1 Oct - 2 Oct

includes taxes & fees

7/10 Good! (260 reviews)

Baymont by Wyndham Santee

249 Britain Street Santee SC

HK$627

HK$696 total

13 Sept - 14 Sept

includes taxes & fees

8/10 Very good! (1,487 reviews)

SureStay Hotel by Best Western Manning

2816 Paxville Highway Manning SC

HK$642

HK$713 total

23 Sept - 24 Sept

includes taxes & fees

8.6/10 Excellent! (1,000 reviews)

Tru By Hilton Santee

263 Britain St. and 273 Britain St. Santee SC

HK$765

HK$849 total

27 Sept - 28 Sept

includes taxes & fees

9.2/10 Wonderful! (949 reviews)

Spark by Hilton Orangeburg

731 Citadel Road Orangeburg SC

HK$765

HK$849 total

13 Sept - 14 Sept

includes taxes & fees

7.8/10 Good! (1,001 reviews)

Tru by Hilton Orangeburg

739 Citadel Road Orangeburg SC

HK$894

HK$992 total

27 Sept - 28 Sept

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Hotels in Santee with star-rating

Frequently asked questions

Where is the best place for a stay in Santee?

Based on our traveller data, Tru By Hilton Santee is one of the top choices for your stay. This hotel offers free breakfast and an indoor pool. Other good choices for your visit include Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee. See all available top hotels, or vacation rentals in Santee.

What are some of the best holiday rentals that Santee has to offer?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated holiday home rental in Santee is located on a lake, and has a patio, a selection of games and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Another good choice for your trip to Santee is Patio + Pool Table: Lake Marion Getaway. See all vacation rentals in Santee.

If I need to cancel my hotel reservation in Santee, will I receive a refund?

Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.

What's the best place to stay on a budget in Santee?

Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Santee.

What's the best family accommodation in Santee?

Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another good option for your stay with the kids. Find more child-friendly accommodations in Santee.

What is the top LGBTQ-friendly accommodation in Santee?

Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are two other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santee.

What's the best dog-friendly hotel in Santee?

Tru By Hilton Santee is a top dog-friendly hotel, and offers an indoor pool along with free WiFi for its human guests. Two other good options for you and your pet include Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee. See more pet-friendly hotel accommodations in Santee.

What's the best accommodation for a golf trip to Santee?

Ramada by Wyndham Santee I-95 is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Holiday Inn Santee by IHG and Super 8 by Wyndham Santee/I-95. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.

What are some accommodation options with pools in Santee?

Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast and free WiFi. Quality Inn & Suites Santee I-95 is an additional hotel with an on-site pool. View all hotels with pools in Santee.

What is staying in Santee like?

Families will find child-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and cafes. In Santee, there are 151 hotels and other accommodation options to choose from. Find out more about Santee.

What are the top places to visit in Santee?

Favourite places to visit include Santee Cooper Country Club, Santee State Park and Lake Marion. A couple of additional sights to add to your itinerary are Santee National Golf Club and Santee Town Hall. Take a look at what more there is to see and do in Expedia's Santee guide.

What's the seasonal weather like in Santee?

The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.

Santee hotels from HK$509

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santee

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santee hotels

1. Hampton Inn Santee-I-95

2. Fairfield Inn & Suites by Marriott Santee

3. Tru By Hilton Santee

4. Best Western Plus Santee Inn

5. Holiday Inn Santee by IHG

6. Baymont by Wyndham Santee

7. Comfort Inn & Suites Santee

8. Travelodge by Wyndham Santee

9. Quality Inn & Suites Santee I-95

10. Super 8 by Wyndham Santee/I-95

11. Red Roof Inn Santee

12. Econo Lodge Santee

13. Ramada by Wyndham Santee I-95

14. Bells Marina & Resort

15. Fairfield Inn by Marriott Orangeburg

16. Red Roof Inn Orangeburg

17. Tru by Hilton Orangeburg

18. Hampton Inn & Suites Orangeburg

19. SureStay Hotel by Best Western Manning

20. SpringHill Suites by Marriott Orangeburg

Stay near popular Santee attractions

Santee State Park

Santee Cooper Country Club

Santee National Golf Club

Santee Town Hall

Learn more about Santee

Top Santee Hotel Reviews

Holiday Inn Santee by IHG

Tru By Hilton Santee

SureStay Hotel by Best Western Manning

Hampton Inn Santee-I-95

Baymont by Wyndham Santee

Red Roof Inn Santee

Waterfront Lake Marion Retreat • Pool • Gazebo • Minutes from I-95

Travelodge by Wyndham Santee

Ramada by Wyndham Santee I-95

More cheap stays in Santee

Peach Tree Inn

Baymont by Wyndham Santee

SureStay Hotel by Best Western Manning

Tru By Hilton Santee

Spark by Hilton Orangeburg

Tru by Hilton Orangeburg

Hotels in Santee with star-rating

Frequently asked questions

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