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Southern Illinois Business Hotel

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Check availability on Southern Illinois Business Hotel

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Southern Illinois business-friendly hotels

Exterior
Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1002)
"Clean room, excellent staff."
United States
Nancy
The price is HK$809
HK$906 total
includes taxes & fees
10 Jan - 11 Jan 2026
Holiday Inn Express & Suites Effingham by IHG
Lobby
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1006)
"Check in was quick, staff was friendly and helpful, room was very nice and clean."
United States
Don
The price is HK$848
HK$957 total
includes taxes & fees
22 Dec - 23 Dec
Comfort Suites Mount Vernon
Exterior
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1002)
"Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!"
United States
Barbara
The price is HK$721
HK$807 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Effingham
Lobby lounge
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1584)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is HK$731
HK$827 total
includes taxes & fees
25 Dec - 26 Dec
Drury Plaza Hotel Mt. Vernon
Lobby
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1003)
"Hotel is very clean and staff is also friendly."
United States
Tonya
The price is HK$506
HK$607 total
includes taxes & fees
2 Jan - 3 Jan 2026
Drury Inn & Suites Marion
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (905)
"Great place to stay."
United States
Stephen
The price is HK$529
HK$587 total
includes taxes & fees
31 Dec - 1 Jan 2026
SureStay Hotel by Best Western Whittington Rend Lake
Front of property – evening/night
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1000)
"Clean rooms and kind staff"
United States
Linda
The price is HK$694
HK$771 total
includes taxes & fees
20 Jan - 21 Jan 2026
Country Inn & Suites by Radisson, Effingham, IL
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1001)
"reception was great, room clean, and the price was right."
United States
tom
The price is HK$518
HK$591 total
includes taxes & fees
4 Jan - 5 Jan 2026
Super 8 by Wyndham Mt. Vernon IL
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (602)
"Very beautiful place to stay "
United States
Valerie
The price is HK$938
HK$1,051 total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus Centralia Hotel & Suites
Exterior
Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG
3.0 star property
Carbondale
8.8 out of 10, Excellent, (642)
"Great staff!"
United States
Greg
The price is HK$879
HK$1,011 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Carbondale-Conference Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

10/10 Excellent
"Rooms are always great. The price is excellent and the staff have always been very friendly. Each time we visit home Illinois we stay there. "
Maaria 2-night trip
Posted 3 days ago
Quality Inn O'Fallon IL - St. Louis

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between HK$587 and HK$1,051 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travellers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travellers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 9.0.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at HK$587 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travellers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're travelling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travellers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favourite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're travelling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.

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