Otay Mesa hotels in San Diego
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Our top choices for Otay Mesa hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.2 out of 10, Very good, (1,775 reviews)
"Was happy with my stay! No complaints 👌"
Rafael
The price is HK$1,191
HK$1,355 total
includes taxes & fees
13 Aug - 14 Aug
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.2 out of 10, Good, (1,024 reviews)
"Very clean, bed was comfortable!"
Michael A
The price is HK$933
HK$1,061 total
includes taxes & fees
2 Aug - 3 Aug
Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
8.8 out of 10, Excellent, (1,340 reviews)
"Clean room, ac was perfect staff was great"
Brandon
The price is HK$981
HK$1,115 total
includes taxes & fees
2 Aug - 3 Aug
Valli Hi Motel
Valli Hi Motel7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,057 reviews)
"It was a good stay."
AILEEN
The price is HK$705
HK$804 total
includes taxes & fees
27 Jul - 28 Jul
Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,904 reviews)
"Nice location and clean hotel."
Abdelghani
The price is HK$1,454
HK$1,602 total
includes taxes & fees
12 Aug - 13 Aug
Holiday Inn Express San Diego South - Chula Vista by IHG
Holiday Inn Express San Diego South - Chula Vista by IHG14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,308 reviews)
"We had a very wonderful time at our stay here"
Liezl
The price is HK$1,256
HK$1,382 total
includes taxes & fees
11 Aug - 12 Aug
Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,731 reviews)
"As usual everything about our stay was great."
Edward
The price is HK$1,299
HK$1,493 total
includes taxes & fees
3 Aug - 4 Aug
Motel 6 El Cajon, CA - San Diego
Motel 6 El Cajon, CA - San Diego27 km from Otay Mesa
7.4 out of 10, Good, (1,715 reviews)
"A good place to stay if you need a place to crash in for the night"
Ivy Ruth
The price is HK$641
HK$739 total
includes taxes & fees
16 Jul - 17 Jul
Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,101 reviews)
"We really enjoyed the cleanliness and the manager Karen was excellent 😊"
Deniece
The price is HK$1,622
HK$1,788 total
includes taxes & fees
2 Aug - 3 Aug
Old Town Inn
Old Town Inn30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,910 reviews)
"Clean room and great breakfast."
Michael
The price is HK$1,383
HK$1,677 total
includes taxes & fees
13 Aug - 14 Aug
Sheraton San Diego Resort
Sheraton San Diego Resort28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,572 reviews)
"Great stay"
Karen
The price is HK$1,458
HK$2,072 total
includes taxes & fees
14 Aug - 15 Aug
Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South13 km from Otay Mesa
8.2 out of 10, Very good, (1,601 reviews)
"The room was comfortable and conveniently located. Breakfast was great for the cost of our stay."
Arsenia P
The price is HK$992
HK$1,093 total
includes taxes & fees
9 Aug - 10 Aug
Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel7.1 km from Otay Mesa
8.0 out of 10, Very good, (1,872 reviews)
"Nice right by the concert we were going to and staff was nice."
vanessa
The price is HK$993
HK$1,094 total
includes taxes & fees
2 Aug - 3 Aug
TownePlace Suites by Marriott San Diego Airport/Liberty Station
TownePlace Suites by Marriott San Diego Airport/Liberty Station29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,007 reviews)
"So convenient, great staff, excellent shuttle service, clean hotel I was very impressed."
Terry
The price is HK$1,560
HK$1,793 total
includes taxes & fees
2 Aug - 3 Aug
La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,662 reviews)
"Very nice and clean hotel"
Lidia
The price is HK$981
HK$1,079 total
includes taxes & fees
9 Aug - 10 Aug
Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,084 reviews)
"Very good hotel at the price with good choice of breakfast."
Tirthankar
The price is HK$1,372
HK$1,577 total
includes taxes & fees
19 Jul - 20 Jul
Lafayette Hotel & Club
Lafayette Hotel & Club26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,809 reviews)
"Great experience, staff was excellent food was delicious.. definitely recommend the hotel!"
Lisa
The price is HK$2,257
HK$2,595 total
includes taxes & fees
21 Jul - 22 Jul
Best Western Plus Hacienda Hotel Old Town
Best Western Plus Hacienda Hotel Old TownOld Town San Diego, 29.9 km from Otay Mesa
8.4 out of 10, Very good, (2,062 reviews)
"Clean room, staff were amazing and location was great!"
Joy
The price is HK$1,235
HK$1,419 total
includes taxes & fees
19 Jul - 20 Jul
Wyndham San Diego Bayside
Wyndham San Diego Bayside25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,215 reviews)
"very good hotel location, close to all restaurants, bay, Little Italy"
Oxana
The price is HK$1,206
HK$1,671 total
includes taxes & fees
29 Jul - 30 Jul
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,026 reviews)
"Exceptional hotel, staff and amenities. Love this hotel!"
CAROL
The price is HK$973
HK$1,164 total
includes taxes & fees
11 Aug - 12 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Seaport Village are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
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