A coastal landscape with clear turquoise waters, a long bridge, and a small island with buildings.

Lower Florida Keys 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Lower Florida Keys 4 Star Hotels

Tonight
3 Sept - 4 Sept
Tomorrow
4 Sept - 5 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Lower Florida Keys 4-star hotels

A room with a view of the beach and ocean, a bed with a white and blue blanket, and a small table with a potted plant.
A poolside area with lounge chairs and umbrellas, palm trees, and a view of the sea.
A beachside lounge with chairs and umbrellas, overlooking the ocean.
A beachfront resort with a prominent sign, white balconies, and tropical landscaping.

1. Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses
Old Town Key West
United States
Deaenna
HK$1,139
HK$1,855 total
includes taxes & fees
9 Sept - 10 Sept
Southernmost Beach Resort and Guesthouses
A hotel with a swimming pool, balconies, and a view of the sea.
A beach wedding setup with white chairs, a wooden arch, and lanterns.
A marina with jet skis docked in front of a hotel with a dock and a boat in the background.
A spacious bar area with a wooden counter and green bar stools, a seating area with a sofa and chairs, and a dining area with a table set for two.

2. Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa
Key West Historic District
United States
JASON
HK$1,576
HK$2,320 total
includes taxes & fees
29 Sept - 30 Sept
Hyatt Centric Key West Resort and Spa
A hotel with a large pool, multiple balconies, and palm trees.
A couple holding hands in a tropical setting with palm trees and greenery.
A modern cafe with a wooden counter, seating area, and shelves stocked with beverages.
A hotel room with a bed, a sofa, a round table with a book, a window with a view, and a radiator.

3. Blue Flamingo Resort Key West

Blue Flamingo Resort Key West
New Town
United States
REBECCA
HK$860
HK$1,408 total
includes taxes & fees
8 Sept - 9 Sept
Blue Flamingo Resort Key West
A beachfront hotel with a covered patio, palm trees, and a boat on the sand.
A pool area with lounge chairs and umbrellas, surrounded by palm trees and a building with balconies.
A resort with a beach, a dock, and a water view.
A balcony with a view of the ocean, a sofa, and a massage table.

4. Pier House Resort & Spa

Pier House Resort & Spa
Key West Historic District
United States
Mark
HK$2,274
HK$3,105 total
includes taxes & fees
9 Sept - 10 Sept
Pier House Resort & Spa
A dining table with plates of food, a drink, and a view of a pool and palm trees.
A hotel entrance with a palm tree-lined driveway, a vintage car, and a metal canopy structure.
A person standing by a window overlooking a beach with palm trees and the ocean.
A hotel room with a bed, a TV, a coffee table, a sofa, and a view of the ocean.

5. Margaritaville Beach House Key West

Margaritaville Beach House Key West
Key West
United States
TRICIA LYNN
HK$1,396
HK$2,062 total
includes taxes & fees
16 Sept - 17 Sept
Margaritaville Beach House Key West
A multi-story hotel with a pink facade, multiple balconies, and a prominent 'LA CONCHA' sign.
A balcony with a sofa, a round table, and a view of the cityscape.
A modern hotel entrance with a black and white striped curtain, wicker furniture, potted plants, and a sign for the Autograph Collection.
A spacious lobby with a checkered floor, a central seating area with wicker chairs, a large potted plant, and a staircase with a metal railing.

6. La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection
Key West Historic District
United States
Fatima
HK$1,325
HK$1,755 total
includes taxes & fees
16 Sept - 17 Sept
La Concha Key West, Autograph Collection
A swimming pool surrounded by palm trees and a natural rock formation.
A bar setting with a bartender preparing a drink, a counter with various bottles, and a TV screen in the background.
A cozy room with wicker furniture, a glass coffee table, and a view of lush greenery outside.
A pool area with lounge chairs and umbrellas, surrounded by palm trees.

7. Havana Cabana at Key West

Havana Cabana at Key West
New Town
United Kingdom
Fabrizio
HK$839
HK$1,439 total
includes taxes & fees
22 Sept - 23 Sept
Havana Cabana at Key West
A pool area with lounge chairs and palm trees, surrounded by boats and a sunset in the background.
An outdoor seating area with tables and chairs, overlooking a marina with boats.
A restaurant with wooden tables and chairs, a counter with seafood signs, and large windows.
A marina with numerous yachts docked, surrounded by palm trees and a clear sky.

8. The Perry Hotel & Marina Key West

The Perry Hotel & Marina Key West
Stock Island
United States
Boyan
HK$1,106
HK$1,728 total
includes taxes & fees
21 Sept - 22 Sept
The Perry Hotel & Marina Key West
A wooden deck with wicker furniture and a glass balustrade overlooking a beach.
A spacious lobby with green sofas, a coffee table, and a dining area.
A resort with a pool leading to a beach, surrounded by palm trees and white buildings.
A beach with white lounge chairs and umbrellas, a sandy shore, and a calm sea under a partly cloudy sky.

9. Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton
Old Town Key West
United States
Dirk
HK$1,660
HK$2,396 total
includes taxes & fees
14 Sept - 15 Sept
Casa Marina Key West, Curio Collection by Hilton
A wooden archway leading to a pool area surrounded by lush tropical vegetation.
A beach with palm trees, a sandy shore, and a calm sea under a clear sky.
A large, two-story building with a symmetrical facade, a central entrance with a double door, and a balcony on the upper floor.
A tall palm tree with a white building in the background.

10. Parrot Key Hotel & Villas

Parrot Key Hotel & Villas
Northside Resort
United States
Melvin
HK$1,035
HK$1,614 total
includes taxes & fees
16 Sept - 17 Sept
Parrot Key Hotel & Villas
A clear swimming pool with lounge chairs and gazebos, surrounded by palm trees.
An outdoor patio with tables and chairs, umbrellas, and palm trees.
A hotel with a central courtyard, palm trees, and a fountain.
A spacious living area with a high ceiling, a blue accent wall, and a wooden staircase.

11. DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West
Key West
United States
Jose
HK$866
HK$1,239 total
includes taxes & fees
17 Sept - 18 Sept
DoubleTree Resort by Hilton Grand Key - Key West
A marina with boats docked, a pool area, and a building with a white facade.
A clear view of turquoise ocean water and a blue sky with clouds.
A marina with numerous boats docked, a swimming pool, and palm trees.
A breakfast setting with a table, chairs, a vase with flowers, and a city view.

12. Hilton Key West Resort & Marina

Hilton Key West Resort & Marina
Stock Island
United States
Linda
HK$894
HK$1,474 total
includes taxes & fees
9 Sept - 10 Sept
Hilton Key West Resort & Marina
A hotel with a covered entrance, multiple balconies, and palm trees.
A room with a stone wall, a wooden bench, a cactus, and a framed painting.
A restaurant interior with wooden beams, a bar area, and a colorful ceiling mural.
A waterfront hotel with multiple balconies, a dock, and boats.

13. Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
Old Town Key West
United States
Melissa
HK$2,031
HK$2,593 total
includes taxes & fees
21 Sept - 22 Sept
Opal Key Resort & Marina, Key West
A two-story building with a covered entrance, palm trees, and a bench outside.
A white building with a sign reading 'Kimpton Key West Winslow's Bungalow.'
A bright room with a staircase, two windows overlooking a pool area, and two wicker chairs with cushions.
A poolside area with lounge chairs, umbrellas, and a covered seating area with hanging lights.

14. Winslow's Bungalows - Key West Historic Inns

Winslow's Bungalows - Key West Historic Inns
Old Town Key West
United States
Stacey
HK$1,529
HK$2,117 total
includes taxes & fees
7 Sept - 8 Sept
Winslow's Bungalows - Key West Historic Inns
A beach with a wooden pier, palm trees, and beach umbrellas.
An outdoor dining area with tables set for guests, overlooking a calm sea and a pier.
A modern bar area with a central island, white bar stools, and a view of the ocean.
A resort with a pool, lounge chairs, umbrellas, palm trees, and a view of the ocean.

15. The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton
Old Town Key West
United States
Joseph
HK$1,540
HK$2,262 total
includes taxes & fees
28 Sept - 29 Sept
The Reach Key West, Curio Collection by Hilton
A pool area with lounge chairs and a cabana.
A hotel room with a bed, a sofa, a desk with a computer, a chair, and a view of the sea through large windows.
A balcony with a table set for breakfast, overlooking the sea.
A dining area with a glass table, clear glass bottles, a bowl of fruit, and a wicker chair.

16. Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort
Key West Historic District
United States
Brian
HK$1,726
HK$2,551 total
includes taxes & fees
28 Sept - 29 Sept
Ocean Key Resort - A Noble House Resort
A large, white, two-story building with a balcony and a sign reading "The Marker Resort."
A tropical setting with palm trees and a building with a white facade and dark roof.
A marina with various boats docked, including a green and white boat named 'Jolly Roger'.
A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

17. The Marker Key West Harbor Resort

The Marker Key West Harbor Resort
Key West Historic District
United States
Joelle
HK$1,425
HK$2,098 total
includes taxes & fees
13 Sept - 14 Sept
The Marker Key West Harbor Resort
A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.
A spacious living area with a gray sofa, wooden staircase, and a kitchen in the background.
A spacious living area with a wooden staircase, a ceiling fan, a TV, and a view of the beach through an open door.
A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

18. Eden House

Eden House
Key West Historic District
United States
Therese
HK$894
HK$1,127 total
includes taxes & fees
8 Sept - 9 Sept
Eden House
A pool area with lounge chairs and palm trees.
A sign for Santa Maria Resort surrounded by lush greenery and palm trees.
A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.
A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.

19. Santa Maria Suites

Santa Maria Suites
Old Town Key West
United States
June Young
HK$2,188
HK$2,990 total
includes taxes & fees
16 Sept - 17 Sept
Santa Maria Suites
A pool area with lounge chairs, a pool with a depth limit sign, and a building with balconies.
A narrow wooden pathway leading to a door, a fire alarm box, and a lattice fence.
A multi-story hotel with balconies, outdoor seating, and palm trees.
A beach with a palm tree and the sun setting over the ocean.

20. Bishop Hotel Key West

Bishop Hotel Key West
Old Town Key West
United States
tracy
Bishop Hotel Key West
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Lower Florida Keys

Discover the local area in Lower Florida Keys as you check out popular sights like Florida Keys Beaches and Duval Street.

See all hotels in Lower Florida Keys
A coastal landscape with clear turquoise waters, a long bridge, and a small island with buildings.

Top Lower Florida Keys Hotel Reviews

Explore a world of travel with Expedia