Cape Girardeau Saint Francis Medical Center Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Saint Francis Medical Center

Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 star property
0.5 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (781)
"Excellent stay"
United States
Christina
The price is HK$772
HK$871 total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
0.8 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
The price is HK$701
HK$790 total
includes taxes & fees
11 Dec - 12 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
0.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is HK$740
HK$834 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
0.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (1000)
"I do love this hotel chain. Another great visit!"
United States
Mark
The price is HK$701
HK$790 total
includes taxes & fees
11 Dec - 12 Dec
Drury Inn & Suites Cape Girardeau
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
1.5 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (139)
"Nice hotel, clean and comfortable "
United States
Laura
The price is HK$685
HK$773 total
includes taxes & fees
14 Dec - 15 Dec
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
0.4 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is HK$545
HK$615 total
includes taxes & fees
10 Dec - 11 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property
1.6 km from Saint Francis Medical Center
8.0 out of 10, Very good, (876)
"Clean room, low noise and very comfortable!"
United States
Richard
The price is HK$545
HK$658 total
includes taxes & fees
14 Dec - 15 Dec
Candlewood Suites Cape Girardeau by IHG
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 star property
2 km from Saint Francis Medical Center
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is HK$428
HK$500 total
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
0.8 km from Saint Francis Medical Center
9.0 out of 10, Wonderful, (1002)
"Great stay"
United States
Heather
The price is HK$545
HK$615 total
includes taxes & fees
10 Dec - 11 Dec
Pear Tree Inn Cape Girardeau West
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
4.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is HK$903
HK$1,023 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Cape Girardeau Downtown
Room
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 star property
5.7 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (99)
"It was a nice stay"
United States
Douglas
The price is HK$679
HK$773 total
includes taxes & fees
14 Dec - 15 Dec
Tru By Hilton Cape Girardeau
Lobby sitting area
The Riverview

The Riverview

4.0 star property
4.9 km from Saint Francis Medical Center
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
United States
ryan
The price is HK$667
HK$753 total
includes taxes & fees
8 Dec - 9 Dec
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
6.7 km from Saint Francis Medical Center
8.8 out of 10, Excellent, (660)
"Great place "
United States
GUY
The price is HK$609
HK$659 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
15.3 km from Saint Francis Medical Center
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is HK$646
HK$683 total
includes taxes & fees
8 Dec - 9 Dec
Drury Inn & Suites Jackson MO
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 star property
6.7 km from Saint Francis Medical Center
8.2 out of 10, Very good, (739)
"Dirty "
United States
Jon
The price is HK$621
HK$672 total
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites Jackson-Cape Girardeau
Lobby
Quality Inn

Quality Inn

2.5 star property
3.8 km from Saint Francis Medical Center
7.2 out of 10, Good, (680)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is HK$469
HK$529 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn
Free WiFi, bed sheets
Town House Inn

Town House Inn

2.5 star property
11.4 km from Saint Francis Medical Center
7.6 out of 10, Good, (422)
"Room was clean and had a refrigerator and microwave for use if needed."
United States
Sherry
The price is HK$541
HK$586 total
includes taxes & fees
8 Dec - 9 Dec
Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Saint Francis Medical Center Hotel Reviews

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent
"Excellent looking room. Service was great."
Oge and Precious 1-night trip
Posted 4 days ago
Hampton Inn Cape Girardeau I 55 East

Hotels near other Saint Francis Medical Center attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Medical Center?
Saint Francis Medical Center is located in Cape Girardeau. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 9 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Saint Francis Medical Center?
Adjacent to Saint Francis Medical Center, Pear Tree Inn Cape Girardeau Near the Medical Center is one of the top choices for your stay based on our traveller data, and this hotel offers free WiFi and LCD TVs. Other good choices within a short distance include Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West.
How many hotels are there close to Saint Francis Medical Center?
Expedia has 9 hotels and other accommodation options within a mile from Saint Francis Medical Center.
If I need to cancel the hotel reservation for my stay near Saint Francis Medical Center, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Saint Francis Medical Center.
What can I see and do near Saint Francis Medical Center?
You might spend a leisurely day outdoors at Fort D Historic Site and Cape Rock Park. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.

Explore a world of travel with Expedia