Photo by Michael True

Defiance hotels from HK$477

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending Defiance hotels

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1001)
"Great place to stay! "
The price is HK$1,014
HK$1,176 total
includes taxes & fees
9 Sept - 10 Sept
Drury Plaza Hotel St. Louis Chesterfield

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (997)
"Clean stay at an affordable price. "
The price is HK$751
HK$860 total
includes taxes & fees
5 Oct - 6 Oct
Baymont by Wyndham Warrenton

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
8.8 out of 10, Excellent, (695)
"Nice location, with a couple restaurants nearby. Quiet, clean, nice beds/pillows."
The price is HK$1,173
HK$1,391 total
includes taxes & fees
6 Sept - 7 Sept
Hilton Garden Inn St. Louis/O'Fallon MO

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very good, (1000)
"Very good hotel for the price"
The price is HK$696
HK$804 total
includes taxes & fees
10 Sept - 11 Sept
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1000)
"We liked the indoor/outdoor pool, the free drinks, and the breakfast was great"
The price is HK$858
HK$995 total
includes taxes & fees
28 Sept - 29 Sept
Drury Plaza Hotel St. Louis St. Charles

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 star property
9.0 out of 10, Wonderful, (960)
"Comfortable beds, good breakfast, and great hotel!"
The price is HK$968
HK$1,127 total
includes taxes & fees
6 Sept - 7 Sept
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1562)
"Great place to stay."
The Wildwood Hotel

Best Western Plus Fenton

2.5 star property
9.2 out of 10, Wonderful, (107)
"Great stay! "
The price is HK$774
HK$894 total
includes taxes & fees
8 Sept - 9 Sept
Best Western Plus Fenton

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
9.4 out of 10, Exceptional, (795)
"Very clean and nice hotel overall"
The price is HK$1,054
HK$1,256 total
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Quality Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very good, (336)
"Pool was small. Staff was great. Room was very clean and well maintained. Overall very nice stay. "
The price is HK$772
HK$884 total
includes taxes & fees
7 Sept - 8 Sept
Quality Inn Near Six Flags St. Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1001)
"Perfect place to stay, very clean and quiet."
The price is HK$723
HK$853 total
includes taxes & fees
8 Sept - 9 Sept
Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1006)
"And nice hotel at a nice price "
The price is HK$582
HK$686 total
includes taxes & fees
29 Sept - 30 Sept
Comfort Inn & Suites St. Louis - O'Fallon

Super 8 by Wyndham Warrenton

2.0 star property
7.4 out of 10, Good, (587)
"Staff was extremely accommodating and friendly."
The price is HK$491
HK$562 total
includes taxes & fees
10 Sept - 11 Sept
Super 8 by Wyndham Warrenton

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (776)
"Friendly staff and clean, fresh smelling rooms."
The price is HK$788
HK$929 total
includes taxes & fees
9 Sept - 10 Sept
Holiday Inn Express St. Louis West - O'Fallon by IHG

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very good, (1015)
"Everything was great, clean, close to the places we were going too. "
The price is HK$817
HK$939 total
includes taxes & fees
7 Sept - 8 Sept
Comfort Suites St Charles - St Louis

Best Western Plus The Charles Hotel

3.0 star property
8.0 out of 10, Very good, (1000)
"I enjoyed my stay the food was good!"
The price is HK$723
HK$838 total
includes taxes & fees
9 Sept - 10 Sept
Best Western Plus The Charles Hotel

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (901)
"Property was clean and the bed was very comfortable. We had a great stay and would likely stay there again if we are in the area. "
The price is HK$578
HK$632 total
includes taxes & fees
6 Sept - 7 Sept
Super 8 by Wyndham St. Clair MO

Hampton Inn St. Charles St. Peters

2.5 star property
8.0 out of 10, Very good, (1000)
"Easily accessible from I-70."
The price is HK$696
HK$800 total
includes taxes & fees
5 Oct - 6 Oct
Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
9.4 out of 10, Exceptional, (1003)
"The hotel is so warm and comforting and fits right into the quaint downtown area. "
The price is HK$822
HK$945 total
includes taxes & fees
7 Sept - 8 Sept
Country Inn & Suites by Radisson, St. Charles Historic District

Fairfield Inn & Suites Wentzville

2.5 star property
9.0 out of 10, Wonderful, (604)
"Wonderful place to stay."
The price is HK$1,069
HK$1,224 total
includes taxes & fees
8 Sept - 9 Sept
Fairfield Inn & Suites Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Defiance Hotels Near an Attraction

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

More cheap stays in Defiance

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West. See all available top hotels, or vacation rentals in Defiance.

What are some of the best holiday rentals that Defiance has to offer?

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway: This holiday home rental outside of Defiance is located on a lake, and has a furnished patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?
How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 17 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.