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Southern Illinois Business Hotel

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Check availability on Southern Illinois Business Hotel

Our top choices for Southern Illinois business-friendly hotels

Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3.0 star property
Marion
9.4 out of 10, Exceptional, (1002)
"Great hotel and very clean "
United States
Jose
The price is HK$506
HK$607 total
includes taxes & fees
2 Jan - 3 Jan 2026
Drury Inn & Suites Marion
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1008)
"Rooms have been painted great breakfast close to interstate and restaurants"
United States
Stephen
The price is HK$849
HK$957 total
includes taxes & fees
10 Dec - 11 Dec
Comfort Suites Mount Vernon
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

2.5 star property
Marion
9.0 out of 10, Wonderful, (925)
"yes the room was great and the staff was great! "
United States
Amador
The price is HK$755
HK$906 total
includes taxes & fees
9 Jan - 10 Jan 2026
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1566)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is HK$731
HK$827 total
includes taxes & fees
17 Dec - 18 Dec
Drury Plaza Hotel Mt. Vernon
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

2.5 star property
Mount Vernon
7.8 out of 10, Good, (1003)
"reception was great, room clean, and the price was right."
United States
tom
The price is HK$483
HK$552 total
includes taxes & fees
4 Jan - 5 Jan 2026
Super 8 by Wyndham Mt. Vernon IL
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3.0 star property
Effingham
9.2 out of 10, Wonderful, (1005)
"Clean room, excellent location, pet friendly. Would definitely book again. "
United States
Misty
The price is HK$721
HK$807 total
includes taxes & fees
28 Dec - 29 Dec
La Quinta Inn & Suites by Wyndham Effingham
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
Whittington
8.8 out of 10, Excellent, (903)
"Great place to stay."
United States
Stephen
The price is HK$562
HK$624 total
includes taxes & fees
31 Dec - 1 Jan 2026
SureStay Hotel by Best Western Whittington Rend Lake
Desk, soundproofing, iron/ironing board, rollaway beds
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 star property
Effingham
8.8 out of 10, Excellent, (1000)
"Clean rooms and kind staff"
United States
Linda
The price is HK$727
HK$807 total
includes taxes & fees
29 Dec - 30 Dec
Country Inn & Suites by Radisson, Effingham, IL
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

2.5 star property
Centralia
9.6 out of 10, Exceptional, (598)
"Very beautiful place to stay "
United States
Valerie
The price is HK$938
HK$1,051 total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus Centralia Hotel & Suites
Free daily continental breakfast
Best Western Delta Inn

Best Western Delta Inn

2.5 star property
Effingham
9.2 out of 10, Wonderful, (1002)
"Clean room, courteous staff, nice amenities."
United States
Richard M
The price is HK$655
HK$733 total
includes taxes & fees
7 Jan - 8 Jan 2026
Best Western Delta Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

10/10 Excellent
"Room was clean, staff were really nice & helpful!! We will be back!"
Shkaia 1-night trip
Posted 1 day ago
Red Lion Inn & Suites Pontoon Beach

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Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between HK$552 and HK$1,051 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travellers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travellers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 9.0.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at HK$552 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travellers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're travelling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travellers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favourite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're travelling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.