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Cairo Fort Defiance State Park Hotels

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Check prices for these dates

Tonight
12 Oct - 13 Oct
Tomorrow
13 Oct - 14 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Fort Defiance State Park hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.
A motel with a red roof and beige walls, a parking lot, and a signboard.
A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.

1. La Center Motel

La Center Motel
17.5 km from Fort Defiance State Park
United States
Carrie
HK$381
HK$450 total
includes taxes & fees
13 Oct - 14 Oct
La Center Motel
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A reception area with a counter, a flat-screen TV, and a window with blinds.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
17.5 km from Fort Defiance State Park
United States
William
HK$467
HK$523 total
includes taxes & fees
20 Oct - 21 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
20.2 km from Fort Defiance State Park
United States
Kathleen
HK$522
HK$584 total
includes taxes & fees
14 Oct - 15 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel lobby with a reception desk, seating area, and a large window.
A hotel room with a desk, chair, television, and a lamp.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
7.8 km from Fort Defiance State Park
United States
Santiago
HK$541
HK$601 total
includes taxes & fees
2 Nov - 3 Nov
Quality Inn Cairo I-57
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

5. Eagle Inn Charleston

Eagle Inn Charleston
16.2 km from Fort Defiance State Park
United States
Jackson
HK$518
HK$580 total
includes taxes & fees
13 Oct - 14 Oct
Eagle Inn Charleston
View all properties

Compare popular hotels close to Fort Defiance State Park

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
La Center Motel
7.6
Good
22 reviews
View
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
Super 8 by Wyndham Charleston/Sikeston East MO
6.8
676 reviews
View
A building with a fountain and flower beds in front.
The Riverstone Hotel Charleston-Sikeston
6.8
441 reviews
View
A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57
6.4
296 reviews
View
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
Eagle Inn Charleston
6.6
107 reviews
View

Top Fort Defiance State Park Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

8/10 Good
"It is a clean place, and we enjoyed our stay"
Laura 1-night trip
Posted 2 hours ago
Super 8 by Wyndham Sikeston/Miner Area
Drury Inn & Suites Paducah

Drury Inn & Suites Paducah

10/10 Excellent
"This is the place to stay! Clean, comfortable rooms, great food, and friendly staff. We’ll be back!"
James 1-night trip
Posted 9 hours ago
Drury Inn & Suites Paducah
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Awesome place will be staying in more of them"
Tim 1-night trip
Posted 18 hours ago
Drury Inn & Suites Sikeston, MO
Comfort Inn Paducah I-24

Comfort Inn Paducah I-24

10/10 Excellent
"Everything with our stay was very good. Didn't get to use all the amenities as we got in late and left early,"
DONNA 1-night trip
Posted 2 days ago
Comfort Inn Paducah I-24
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

10/10 Excellent
"Dianna was lovely to work with. Great setting, clean and comfortable. Unbeatable price."
Mark S. 1-night trip
Posted 3 days ago
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."
Richard 1-night trip
Posted 3 days ago
Days Inn and Suites by Wyndham Sikeston
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

8/10 Good
"I booked this cabin for a getaway for two adults and two dogs who don't like other dogs, and it was the perfect location for that. There are no other cabins within sight or within earshot, the road that runs by the cabin is quiet, and there's a park that's similarly very quiet about a 5-minute drive away. Check in was smooth and the cabin is very cute. The facilities, especially the shower, are pretty basic, but everything worked. The cabin is small, but comfortable for two people. There's AC and heating, so the temperature was comfortable.My notes are less a critique of the cabin, and more things to know: The water smells like rotten eggs, to the point where the entire bathroom stank after a shower. My dogs happily drank the tap water, so it seems safe - the area is marshy, so I suspect that explains the smell. If you're sensitive to smells, this might be a challenge. This is woods in the southern Midwest, so mosquitoes were out in force, and my dogs were covered in sticky pricklies the second they left the (nicely!) mowed area of the cabin - again, nothing to do with the cabin, just the reality of the area, and it meant we didn't spend a ton of time outside near the cabin. I might be interested in revisiting during a colder time of year when bugs and plants are dormant. I recommend bringing your own dry firewood because it's humid so any wood at the site might not burn very easily."
Elina S. 2-night trip
Posted 7 days ago
Peaceful secluded cabin located near Horseshoe Lake
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"This was one of the most amazing stays at any rental property we have ever had. First let me say the kitchen has every utensil and pot and pan you need. Muffin pans. Baking pans, stainers mugs, plates bowls, cups. Condiments, butter, farm fresh eggs were in the fridge. Snack bars were provided. Charcoal grill was available for use. Everything was clean and orderly. The house has so much heart and soul in it. You can feel the love that has persisted in this house for decades. The yard is shady & spacious for walking your dogs. Jane was a wonderful host and took great care of us. It was a pleasure meeting her. The farm is across from the red house and is home to 20 something horses. It was an all out wonderful and relaxing stay. Don't hesitate to stay with Jane in the redhouse on the farm. It was truly amazing!!"
Chris P. 5-night trip
Posted 12 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 1 month ago
Cozy cabins on beautiful Horseshoe Lake

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

7.4/10 (23 reviews)
You can learn about the history of Columbus when you stop by Columbus-Belmont State Park.
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Ullin City Hall

6.6/10 (4 reviews)
After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums.
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Limekin Springs Trail Trailhead

You can take time to visit Limekin Springs Trail Trailhead during your travels to Ullin. Make some time to visit the shops while you're in the area.
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Front Street Studio & Art Gallery

8.6/10 (15 reviews)
You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savour the top-notch restaurants.
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Lower Cache River Access Area

You can take time to visit Lower Cache River Access Area during your travels to Cypress.
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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.
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Henry N Barkhausen Cache River Wetlands Center

8.0/10 (1 review)
You can spend time studying the exhibits at Henry N Barkhausen Cache River Wetlands Center during your travels in Cypress. Amble around the area's parks or experience its museums.
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Frequently asked questions

What's the area like around Fort Defiance State Park?
Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best place to stay close to Fort Defiance State Park?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.
If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If your reservation is non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best deals available near Fort Defiance State Park.

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