Rochester Mayo Clinic Hotels: 2026 Limited-Time Hotel Deals @Expedia

A historic building with a prominent tower, two American flags, and a modern glass structure in the foreground.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic hotels

Premium bedding, pillow-top beds, laptop workspace, blackout curtains

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Jorge

HK$996

HK$1,147 total

includes taxes & fees

4 Sept - 5 Sept

2. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

HK$1,344

HK$1,548 total

includes taxes & fees

29 Aug - 30 Aug

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Marissa

HK$946

HK$1,089 total

includes taxes & fees

16 Aug - 17 Aug

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Richard

HK$1,035

HK$1,192 total

includes taxes & fees

15 Aug - 16 Aug

5. The Berkman

Folwell, 1.4 km from Mayo Clinic

Jana

HK$1,468

HK$1,707 total

includes taxes & fees

8 Aug - 9 Aug

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

paul

HK$753

HK$973 total

includes taxes & fees

14 Aug - 15 Aug

Indoor pool, pool umbrellas, pool loungers

Premium bedding, down duvets, desk, laptop workspace

7. The Towers At Kahler Grand Hotel

Downtown Rochester, 0.1 km from Mayo Clinic

Chris

HK$2,817

HK$3,243 total

includes taxes & fees

16 Aug - 17 Aug

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Denise

HK$871

HK$1,018 total

includes taxes & fees

6 Sept - 7 Sept

2 restaurants; breakfast, lunch and dinner served

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

HK$887

HK$1,021 total

includes taxes & fees

15 Aug - 16 Aug

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Eric

HK$862

HK$992 total

includes taxes & fees

14 Aug - 15 Aug

Premium bedding, desk, blackout curtains, iron/ironing board

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

HK$910

HK$1,047 total

includes taxes & fees

30 Aug - 31 Aug

In-room safe, desk, laptop workspace, soundproofing

12. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Camille

HK$1,327

HK$1,527 total

includes taxes & fees

4 Sept - 5 Sept

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

Richard

HK$740

HK$852 total

includes taxes & fees

16 Aug - 17 Aug

14. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Denise

HK$536

HK$617 total

includes taxes & fees

30 Aug - 31 Aug

Indoor pool, open 7:00 AM to 10:00 PM, pool loungers

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Bridgett

HK$1,247

HK$1,436 total

includes taxes & fees

15 Aug - 16 Aug

Premium bedding, in-room safe, desk, laptop workspace

16. Aspen Suites

1.2 km from Mayo Clinic

CASEY

HK$1,083

HK$1,309 total

includes taxes & fees

9 Aug - 10 Aug

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Leo

HK$777

HK$894 total

includes taxes & fees

21 Aug - 22 Aug

Desk, iron/ironing board (on request), free WiFi, bed sheets

18. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Bryan

HK$980

HK$1,129 total

includes taxes & fees

15 Aug - 16 Aug

Premium bedding, pillow-top beds, iron/ironing board

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Kim

HK$894

HK$1,029 total

includes taxes & fees

15 Aug - 16 Aug

Down duvets, desk, laptop workspace, iron/ironing board

20. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Cassandra

HK$579

HK$676 total

includes taxes & fees

30 Aug - 31 Aug

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 547 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 630 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 729 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 298 reviews	View
The Berkman	9.6 Exceptional 425 reviews	View

Top Mayo Clinic Hotel Reviews

Brentwood Inn & Suites

8/10 Good

"Clean rooms and property. Breakfast was very basic."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"Enjoyable stay. Nice restaurant. Close to civic center. Shuttle is a real nice extra. Respectful staff. Dated physically, lots of traffic with Mayo near bye. They seem to own near by buildings as well."

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"Check i and out is always fast, Staff is very helpful and the free breakfast is nice, are room was clean and comfortable."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Nice facility, nice rooms."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"We were only there for one night and the entire experience was good. The breakfast was mediocre and pretty typical for free continental breakfast. The hot tub was not in working order, but that happens on occasion. The staff was excellent and very friendly at check-in and allowed us to even have a late checkout, which was helpful. I would stay at this hotel again."

Aspen Suites

10/10 Excellent

"Very much enjoyed my stay here and loved the appliance cabinet downstairs by the front desk, available for guests to borrow from and use in their rooms. Would definitely stay here again."

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"Parking lot (underground) has very small spaces - very difficult for even an average SUV to park. Towel refresh policy unexplained and/or difficult to use."

Kahler Grand Hotel

8/10 Good

"Very close to Mayo clinic and the Peace Plaza. Rooms are very small."

Hilton Garden Inn Rochester Downtown, MN

10/10 Excellent

"Very helpful staff, room was very clean(smelled great) and the whole facility is beautiful! Our second time staying and definitely will stay again."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 148 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 148 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Rochester Mayo Clinic Hotels

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic hotels

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

2. Hilton Rochester Mayo Clinic Area

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

5. The Berkman

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. The Towers At Kahler Grand Hotel

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

12. Broadway Plaza, Trademark Collection by Wyndham

13. Hampton Inn Rochester-South

14. Econo Lodge Mayo Clinic Area

15. Hyatt House Rochester/Mayo Clinic Area

16. Aspen Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Brentwood Inn & Suites

19. Hilton Garden Inn Rochester Downtown, MN

20. Quality Inn & Suites Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Brentwood Inn & Suites

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Aspen Suites

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kahler Grand Hotel

Hilton Garden Inn Rochester Downtown, MN

Frequently asked questions

Explore a world of travel with Expedia