Rochester Mayo Clinic Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Mayo Clinic hotels

An outdoor patio area with a concrete floor, wooden fence, and string lights.

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Brien

HK$967 total

includes taxes & fees

13 Nov - 14 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

2. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

HK$1,644 total

includes taxes & fees

1 Dec - 2 Dec

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

HK$1,191 total

includes taxes & fees

14 Nov - 15 Nov

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

HK$1,527 total

includes taxes & fees

27 Nov - 28 Nov

A coffee shop interior with shelves displaying mugs, a hanging rack with t-shirts, and a wooden bench with folded t-shirts.

5. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Cory

HK$1,236 total

includes taxes & fees

14 Nov - 15 Nov

A modern indoor patio with a fire feature, seating, and large windows.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Ashley

HK$1,099 total

includes taxes & fees

27 Nov - 28 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

7. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Arlan

HK$1,004 total

includes taxes & fees

27 Nov - 28 Nov

A hotel lobby with a reception desk, seating area, and a large window.

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Kevin

HK$966 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

9. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Lorraine

HK$632 total

includes taxes & fees

28 Nov - 29 Nov

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

10. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

HK$1,527 total

includes taxes & fees

27 Nov - 28 Nov

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

KELLY

HK$990 total

includes taxes & fees

22 Nov - 23 Nov

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

12. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

francis

HK$1,020 total

includes taxes & fees

27 Nov - 28 Nov

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

13. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Anne

HK$1,083 total

includes taxes & fees

8 Nov - 9 Nov

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

14. Aspen Suites

1.2 km from Mayo Clinic

Lee

HK$1,252 total

includes taxes & fees

26 Nov - 27 Nov

A modern interior with a bar area, seating, and a large window.

15. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Kathleen

HK$930 total

includes taxes & fees

14 Nov - 15 Nov

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

16. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Mark

HK$607 total

includes taxes & fees

28 Nov - 29 Nov

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

17. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park, 1.1 km from Mayo Clinic

Jackie

HK$926 total

includes taxes & fees

6 Dec - 7 Dec

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

18. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park, 1.6 km from Mayo Clinic

Laura

HK$911 total

includes taxes & fees

14 Nov - 15 Nov

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

19. Kahler Grand Hotel

Downtown Rochester, 0.1 km from Mayo Clinic

Kathryn

HK$1,245 total

includes taxes & fees

26 Nov - 27 Nov

A lobby with leather chairs, a reception desk, a TV, and a coffee station.

20. Aspen Select

Kutzky Park, 1.2 km from Mayo Clinic

Trudy

HK$892 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	3.0 star property	9.6 Exceptional 751 reviews	View
The Berkman	3.0 star property	9.6 Exceptional 454 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	3.0 star property	9.6 Exceptional 321 reviews	View
Hilton Rochester Mayo Clinic Area	3.5 star property	9.6 Exceptional 655 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	3.0 star property	9.6 Exceptional 575 reviews	View

Frequently Asked Questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 153 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 153 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Our top choices for Mayo Clinic hotels

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

2. The Berkman

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

4. Hilton Rochester Mayo Clinic Area

5. TownePlace Suites by Marriott Rochester Mayo Clinic Area

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. Hyatt House Rochester/Mayo Clinic Area

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

9. Econo Lodge Mayo Clinic Area

10. Broadway Plaza, Trademark Collection by Wyndham

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

12. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

13. Brentwood Inn & Suites

14. Aspen Suites

15. Hotel Indigo Rochester – Mayo Clinic Area by IHG

16. Quality Inn & Suites Mayo Clinic Area

17. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

18. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

19. Kahler Grand Hotel

20. Aspen Select

Compare popular hotels close to Mayo Clinic

Frequently Asked Questions

What's the area like around Mayo Clinic?

What's the best place to stay close to Mayo Clinic?

How many hotels should I expect to find near Mayo Clinic?

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

What can I see and do near Mayo Clinic?

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