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Our top choices for Upstate South Carolina hotels

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

1. Hilton Garden Inn Spartanburg

Spartanburg

Patrick

HK$880 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a reception desk, green seating area, and multiple tables and chairs.

2. Home2 Suites by Hilton Duncan

Duncan

Luella

HK$1,065 total

includes taxes & fees

22 Nov - 23 Nov

A modern lobby with a reception desk, seating area, and a television screen.

3. Best Western Spartanburg I-26

Spartanburg

Santhosh

HK$806 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

4. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

david

HK$914 total

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with a central island, bar stools, and pendant lighting.

5. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Melinda

HK$925 total

includes taxes & fees

27 Nov - 28 Nov

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

6. AC Hotel by Marriott Spartanburg

Spartanburg

James

HK$1,102 total

includes taxes & fees

28 Nov - 29 Nov

A modern kitchen with hanging light fixtures and bar seating.

7. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Angie

HK$940 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

8. Comfort Suites At WestGate Mall

Spartanburg

Willie

HK$762 total

includes taxes & fees

29 Nov - 30 Nov

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

9. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

HK$649 total

includes taxes & fees

6 Dec - 7 Dec

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

10. Hotel Hartness

Greenville

Nicole

HK$1,719 total

includes taxes & fees

22 Nov - 23 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

11. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

HK$867 total

includes taxes & fees

23 Nov - 24 Nov

A modern living room with a fireplace, seating area, and a kitchen in the background.

12. Comfort Suites Greenville Airport

Greenville

Adam

HK$789 total

includes taxes & fees

6 Dec - 7 Dec

A modern living room with a fireplace, two sofas, and a coffee table.

13. Best Western Spartanburg Northwest

Spartanburg

Herbert

HK$785 total

includes taxes & fees

6 Dec - 7 Dec

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

14. Four Points by Sheraton Spartanburg

Spartanburg

Marcus

HK$1,028 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor seating area with sofas, a fire pit, and string lights.

15. Tru by Hilton Spartanburg

Spartanburg

Volodymyr

HK$921 total

includes taxes & fees

23 Nov - 24 Nov

A modern interior with a fireplace, seating, and a wooden accent wall.

16. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Nilda

HK$858 total

includes taxes & fees

8 Dec - 9 Dec

A hotel room with two beds, a bedside table, a lamp, and a window with curtains.

17. Clarion Inn

Greenville

Johnny

HK$609 total

includes taxes & fees

29 Nov - 30 Nov

An indoor swimming pool with multiple lanes, lounge chairs, and a clear view of the sky through large windows.

18. Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG

Duncan

Dawn

HK$794 total

includes taxes & fees

10 Dec - 11 Dec

A modern restaurant with a brick wall, wooden ceiling beams, and a central seating area with tables and chairs.

19. Hampton Inn Greer Greenville, SC

Greer

Morgan

HK$1,231 total

includes taxes & fees

18 Nov - 19 Nov

A modern lobby with a fireplace, comfortable seating, and a flat-screen TV.

20. Courtyard Greenville-Spartanburg by Marriott

Greer

Laura

HK$861 total

includes taxes & fees

23 Nov - 24 Nov

View all properties

Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great property and cozy. Safe area and close to mall and restaurants."

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location-we walked to soo many shops and restaurants!"

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Perfect location for getting away in a quiet cabin!"

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

A spacious living room with a dining area, a leather sofa, a TV, and artwork on the walls.

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cottage

A round table with a white tablecloth, surrounded by chairs, set up for a meal.

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A bedroom with a wooden bed, a nightstand, a chair, and a view of the outside through a window.

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Seneca

"The best, perfect "

See all holiday rentals

Hotels recommended for families in Upstate South Carolina

AC Hotel by Marriott Spartanburg

Spartanburg

HK$1,102 total

includes taxes & fees

28 Nov - 29 Nov

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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