Rochester Mayo Clinic Hotels: 2026 Limited-Time Hotel Deals @Expedia

A historic building with a prominent tower, two American flags, and a modern glass structure in the foreground.

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Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

howard

HK$994

HK$1,144 total

includes taxes & fees

24 Oct - 25 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

2. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Robin M.

HK$1,075

HK$1,238 total

includes taxes & fees

23 Oct - 24 Oct

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

HK$876

HK$1,008 total

includes taxes & fees

17 Oct - 18 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

HK$1,083

HK$1,247 total

includes taxes & fees

18 Oct - 19 Oct

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A modern indoor swimming pool with seating areas and a city view.

5. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

HK$1,394

HK$1,605 total

includes taxes & fees

7 Nov - 8 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A modern interior with a large dining table, sofas, and a kitchen area.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

6. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

HK$1,492

HK$1,734 total

includes taxes & fees

1 Nov - 2 Nov

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

An indoor swimming pool with a brick wall, lounge chairs, and a seating area with a fireplace.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Sheri

HK$895

HK$1,046 total

includes taxes & fees

25 Oct - 26 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

8. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

James

HK$957

HK$1,208 total

includes taxes & fees

17 Oct - 18 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

A modern bar area with seating and a counter.

9. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Kitt

HK$926

HK$1,066 total

includes taxes & fees

17 Oct - 18 Oct

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A gym with exercise equipment, a clock, and a window with blinds.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

HK$927

HK$1,067 total

includes taxes & fees

6 Nov - 7 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

11. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

HK$517

HK$595 total

includes taxes & fees

1 Nov - 2 Nov

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

12. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Danny

HK$1,327

HK$1,528 total

includes taxes & fees

17 Oct - 18 Oct

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

A hotel gym with treadmills, elliptical machines, and free weights.

13. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Kevin

HK$910

HK$1,048 total

includes taxes & fees

17 Oct - 18 Oct

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A conference room with a long table, multiple chairs, and decorative wall art.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

14. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

HK$887

HK$1,021 total

includes taxes & fees

6 Nov - 7 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

15. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

HK$860

HK$991 total

includes taxes & fees

18 Oct - 19 Oct

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel room with a kitchenette, a dining area with striped chairs, a sofa, a TV, and a window with curtains.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

16. Aspen Suites

1.2 km from Mayo Clinic

Dana

HK$1,052

HK$1,272 total

includes taxes & fees

23 Oct - 24 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

An outdoor dining area with wooden beams, tables, and chairs.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

thomas

HK$840

HK$967 total

includes taxes & fees

24 Oct - 25 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A reception area with a curved counter, ceiling lights, and a potted plant.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

18. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Daniel

HK$981

HK$1,129 total

includes taxes & fees

29 Oct - 30 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

19. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Jessica

HK$597

HK$696 total

includes taxes & fees

1 Nov - 2 Nov

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A reception area with two counters, a patterned wall, and a wooden floor.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

20. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Richard

HK$927

HK$1,067 total

includes taxes & fees

23 Oct - 24 Oct

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 566 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 742 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 314 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 649 reviews	View

Top Mayo Clinic Hotel Reviews

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"I had a great stay! I was in town for a convention. The shuttle was extremely helpful when available. The included breakfast was good and had plenty of options. The rooms are spacious and clean with everything you need except for an ice bucket lol. The lobby/dining area is clean, cute and a nice area to hangout. Spyhouse coffee being connected is a huge bonus. Parking is easy and accessible but not included which they state before booking a room so not complaining. My only “complaint” would be not having 2 shuttles running with them having knowledge of large events going on and signing on with them but not really a big deal."

Kahler Grand Hotel

8/10 Good

"Staff was great and location is hard to beat when visiting the Mayo Clinic. Included breakfast would have been a huge benefit."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Very nice suite room, very quiet and restful. Front desk staff were helpful and great in helping us with dinner recommendations"

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent

"Great stay for the price. Will stay here again when visiting Rochester MN."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

8/10 Good

"Soap dispensers cumbersome to use hard to read labels. Stayed on fourth floor had elephants checking out at 4:15 am above me-no way normal people could make that much noise for 45 mins Happened next morning with new check in less obtrusive Will definitely request 5th with no one above. Have stayed several times so this was only this stay. Staff is stellar; Linda and Michelle most helpful"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Great room, close to St. Mary’s. Very clean& up to date. Easy parking& access to parking from rooms."

The Berkman

10/10 Excellent

"Room was awesome! We had the 3 bedroom unit, which had a large and spacious balcony. Plenty of sunlight came through those windows. We couldn’t had had a better room!"

Aspen Select

10/10 Excellent

"rooms were great, breakfast a little weak"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Great location. Great accommodations. Highly recommended."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 153 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 153 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Rochester Mayo Clinic Hotels

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. TownePlace Suites by Marriott Rochester Mayo Clinic Area

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

5. Hilton Rochester Mayo Clinic Area

6. The Berkman

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. EVEN Hotel Rochester - Mayo Clinic Area by IHG

9. Hyatt House Rochester/Mayo Clinic Area

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Econo Lodge Mayo Clinic Area

12. Broadway Plaza, Trademark Collection by Wyndham

13. Candlewood Suites Rochester Mayo Clinic Area by IHG

14. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

15. Hampton Inn Rochester-South

16. Aspen Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Brentwood Inn & Suites

19. Quality Inn & Suites Mayo Clinic Area

20. Hilton Garden Inn Rochester Downtown, MN

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kahler Grand Hotel

Hyatt House Rochester/Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

The Berkman

Aspen Select

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Frequently asked questions

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