Best St. Charles Hotels in 2026 from HK$441 - Fully Refundable Options

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Our top choices for St. Charles hotels

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

A multi-story hotel with a prominent "American" sign, a parking lot with several cars, and a landscaped entrance area.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

1. AmericInn by Wyndham Winona

Winona

Jonathan

HK$994

HK$1,110 total

includes taxes & fees

25 Oct - 26 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

2. Hampton Inn Rochester-South

Rochester

dennis

HK$861

HK$991 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

3. Spark by Hilton Rochester South

Rochester

Stanton

HK$640

HK$737 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern indoor pool area with lounge chairs and a pool.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

4. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Elsie

HK$997

HK$1,148 total

includes taxes & fees

29 Oct - 30 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A Holiday Inn Express building with a stone facade and illuminated signage.

A hotel room with a bed, desk, chair, and a bathroom.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

5. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

HK$691

HK$795 total

includes taxes & fees

19 Nov - 20 Nov

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

6. Stone Mill Hotel & Suites

Lanesboro

Bernie

HK$824

HK$885 total

includes taxes & fees

26 Oct - 27 Oct

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A hotel room with two beds, a desk, a chair, and a mirror.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

7. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

blake

HK$573

HK$659 total

includes taxes & fees

25 Oct - 26 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

8. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

HK$1,075

HK$1,238 total

includes taxes & fees

13 Nov - 14 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

A modern restaurant with a counter, seating area, and a TV screen.

9. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

HK$927

HK$1,068 total

includes taxes & fees

12 Nov - 13 Nov

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

10. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Cory

HK$1,075

HK$1,238 total

includes taxes & fees

7 Nov - 8 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

11. Econo Lodge Mayo Clinic Area

Rochester

Ashley

HK$524

HK$603 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A restaurant interior with wooden tables, chairs, and a stone wall.

12. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Deanna

HK$896

HK$1,032 total

includes taxes & fees

23 Oct - 24 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A reception area with a curved counter, ceiling lights, and a potted plant.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

13. Brentwood Inn & Suites

Downtown Rochester

Elaine

HK$942

HK$1,084 total

includes taxes & fees

24 Oct - 25 Oct

A hotel room with two beds, a desk, a chair, and a lamp.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

14. Country Trails Inn & Suites

Preston

Jeannie

HK$993

HK$1,096 total

includes taxes & fees

26 Oct - 27 Oct

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A coffee station with two espresso machines and a variety of coffee pods and cups.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

15. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

HK$793

HK$913 total

includes taxes & fees

24 Oct - 25 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

James

HK$894

HK$1,045 total

includes taxes & fees

23 Oct - 24 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

An outdoor dining area with wooden beams, tables, and chairs.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

Naomi

HK$840

HK$967 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

18. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Brien

HK$947

HK$1,090 total

includes taxes & fees

6 Nov - 7 Nov

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A reception area with two counters, a patterned wall, and a wooden floor.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester

Richard

HK$927

HK$1,068 total

includes taxes & fees

7 Nov - 8 Nov

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

20. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Alvaro

HK$560

HK$645 total

includes taxes & fees

1 Nov - 2 Nov

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St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Kahler Grand Hotel

10/10 Excellent

"This Hotel has clean rooms with a microwave and small fridge. The front desk staff were pleasant and professional"

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Staff were nice. Room was clean. Close enough to Mayo. Quite a few used shuttle from hotel and said it was very convenient."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Beautiful place to stay"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"EVEN is our go-to hotel when visiting Rochester for doctors appointments. It’s close enough to walk and we love the clean modern rooms."

The Plaza Hotel & Suites Winona

10/10 Excellent

"Room was large and comfortable. Great pool and hotter, it was super busy so we did not use it, but it looked fantastic."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"."

Aspen Select

8/10 Good

"Small area to park in and not easy to get to"

Super 8 by Wyndham Winona MN

8/10 Good

"The property is conveniently located where it's just off of the round-about & close to the grocery store, gas station, Target shopping store, Farm & Fleet, etc. Staff was helpful in getting a room close to the door & a flight of stairs for senior citizen like us with arhritis & special needs. I specially liked the breakfast of coffee, waffle, yogurt, etc. Too bad there's no egg for my protein needs. The bathroom was very clean. I like the body wash, shampoo & conditioner dispensers. However, the table needs a lamp on the table, an ironing board, and some hangers. Other than that, everything's great. We had a comfortable and wonderful stay! Thank you very much. We will come back again!"

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

HK$388

HK$441 total

15 Nov - 16 Nov

includes taxes & fees

7.6/10 Good! (1,006 reviews)

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

HK$455

HK$524 total

26 Oct - 27 Oct

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

HK$593

HK$683 total

22 Oct - 23 Oct

includes taxes & fees

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

HK$631

HK$727 total

19 Nov - 20 Nov

includes taxes & fees

8.8/10 Excellent! (1,003 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

HK$691

HK$795 total

19 Nov - 20 Nov

includes taxes & fees

8.8/10 Excellent! (1,000 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

HK$942

HK$1,084 total

24 Oct - 25 Oct

includes taxes & fees

Hotels in St. Charles with star-rating

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

What are some of the best holiday rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of St. Charles offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

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St. Charles hotels from HK$441

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for St. Charles hotels

1. AmericInn by Wyndham Winona

2. Hampton Inn Rochester-South

3. Spark by Hilton Rochester South

4. Hyatt House Rochester/Mayo Clinic Area

5. Holiday Inn Express Rochester South - Mayo Area by IHG

6. Stone Mill Hotel & Suites

7. AmericInn by Wyndham Rochester Near Mayo Clinic

8. Residence Inn by Marriott Rochester Mayo Clinic Area South

9. Home2 Suites by Hilton Rochester Mayo Clinic Area

10. TownePlace Suites by Marriott Rochester Mayo Clinic Area

11. Econo Lodge Mayo Clinic Area

12. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

13. Brentwood Inn & Suites

14. Country Trails Inn & Suites

15. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

16. EVEN Hotel Rochester - Mayo Clinic Area by IHG

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

19. Hilton Garden Inn Rochester Downtown, MN

20. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Learn more about St. Charles

Top St. Charles Hotel Reviews

Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

The Plaza Hotel & Suites Winona

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Aspen Select

Super 8 by Wyndham Winona MN

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Holiday Inn Express Rochester South - Mayo Area by IHG

Brentwood Inn & Suites

Hotels in St. Charles with star-rating

Frequently asked questions

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