St. Charles hotels from HK$399

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Go beyond your typical stay in St. Charles

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9 Nov - 10 Nov
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10 Nov - 11 Nov
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13 Nov - 15 Nov
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20 Nov - 22 Nov

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Our top choices for St. Charles hotels

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

1. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,006 reviews)
"Great stay."
Canada
Robert Blaise
The price is HK$872
HK$1,004 total
includes taxes & fees
27 Nov - 28 Nov
Hyatt House Rochester/Mayo Clinic Area
A modern hotel lobby with a reception desk, seating area, and a dining space.

2. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,002 reviews)
"Nice location, easy access and good breakfast."
United States
Rick
The price is HK$643
HK$740 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express Rochester South - Mayo Area by IHG
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

3. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,000 reviews)
"Great stay"
United States
Susan
The price is HK$766
HK$882 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn Rochester-South
A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

4. AmericInn by Wyndham Winona

AmericInn by Wyndham Winona
3.0 star property
Winona
9.0 out of 10, Wonderful, (1,002 reviews)
"Always stay when in the area, great staff and clean rooms."
United States
Jonathan
The price is HK$1,060
HK$1,183 total
includes taxes & fees
22 Nov - 23 Nov
AmericInn by Wyndham Winona
A modern hotel lobby with a reception desk, seating area, and a kitchenette.

5. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (607 reviews)
"Clean room Staff very accommodating Hot coffee and breakfast."
United States
Stanton
The price is HK$526
HK$606 total
includes taxes & fees
22 Nov - 23 Nov
Spark by Hilton Rochester South
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

6. Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
Rochester
9.6 out of 10, Exceptional, (321 reviews)
"Clean hotel, friendly staff, great location."
United States
Chee
The price is HK$1,035
HK$1,191 total
includes taxes & fees
27 Nov - 28 Nov
Residence Inn by Marriott Rochester Mayo Clinic Area South
An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

7. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (1,002 reviews)
"Clean room, very nice staff and nice atmosphere."
United States
howard
The price is HK$873
HK$1,005 total
includes taxes & fees
29 Nov - 30 Nov
Home2 Suites by Hilton Rochester Mayo Clinic Area
A modern kitchen with a central island, wooden cabinets, and pendant lighting.

8. TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Kutzky Park
9.6 out of 10, Exceptional, (576 reviews)
"Excellent service, room was great and the lobby area is great for hanging out in the evenings!"
Canada
Cory
The price is HK$1,074
HK$1,237 total
includes taxes & fees
14 Nov - 15 Nov
TownePlace Suites by Marriott Rochester Mayo Clinic Area
A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

9. Stone Mill Hotel & Suites

Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.6 out of 10, Exceptional, (731 reviews)
"It was a very quaint small town Inn. It reminded me of a Bed and Breakfast. Very comfortable room and nice Restraunts walking distance from the hotel."
United States
Shari
The price is HK$823
HK$884 total
includes taxes & fees
13 Nov - 14 Nov
Stone Mill Hotel & Suites
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

10. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,009 reviews)
"This was a very nice place to stay. It felt cozy, warm.... walking distance to a Perkins. Loved it."
United States
Lorraine
The price is HK$526
HK$606 total
includes taxes & fees
4 Dec - 5 Dec
Econo Lodge Mayo Clinic Area
An outdoor patio area with tables and chairs under umbrellas, surrounded by flower beds and greenery.

11. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3.0 star property
Historic Southwest
8.6 out of 10, Excellent, (1,018 reviews)
"Beautiful place to stay"
United States
Deanna
The price is HK$895
HK$1,031 total
includes taxes & fees
14 Nov - 15 Nov
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

12. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.6 out of 10, Good, (1,061 reviews)
"The property was very reasonable in price. It was also very clean and staff very helpful."
United States
Lavon
The price is HK$560
HK$644 total
includes taxes & fees
15 Nov - 16 Nov
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

13. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,009 reviews)
"Great place to stay."
United States
LeeAnn
The price is HK$635
HK$731 total
includes taxes & fees
10 Dec - 11 Dec
Comfort Inn & Suites Rochester South Mayo Clinic
A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

14. Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (656 reviews)
"Clean rooms, great staff, convenient location."
United States
Jennifer
The price is HK$1,326
HK$1,527 total
includes taxes & fees
27 Nov - 28 Nov
Hilton Rochester Mayo Clinic Area
Room

15. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,603 reviews)
"Was a quick and comfortable stay."
United States
Tammy
The price is HK$572
HK$659 total
includes taxes & fees
6 Dec - 7 Dec
AmericInn by Wyndham Rochester Near Mayo Clinic
A modern living room with a fireplace, comfortable seating, and large windows.

16. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (563 reviews)
"Love this place!"
United States
Sheri
The price is HK$823
HK$963 total
includes taxes & fees
25 Nov - 26 Nov
Staybridge Suites Rochester - Mayo Clinic Area by IHG
A hotel room with two beds, a desk, a chair, and a lamp.

17. Country Trails Inn & Suites

Country Trails Inn & Suites
2.0 star property
Preston
9.4 out of 10, Exceptional, (164 reviews)
"Very nice place to stay."
United States
Jeannie
The price is HK$992
HK$1,095 total
includes taxes & fees
10 Nov - 11 Nov
Country Trails Inn & Suites
A modern interior with a bar area, seating, and a large window.

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,004 reviews)
"This was a nice hotel with a great location. There were several bars and restaurants within walking distance."
United States
Kathleen
The price is HK$760
HK$876 total
includes taxes & fees
28 Nov - 29 Nov
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

19. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (972 reviews)
"Nice location, staff very helpful and friendly, and nice big room"
United States
Mark
The price is HK$548
HK$639 total
includes taxes & fees
28 Nov - 29 Nov
Quality Inn & Suites Mayo Clinic Area
A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

20. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park
8.6 out of 10, Excellent, (850 reviews)
"The staff was super helpful and friendly. My room felt quite clean. The continental breakfast was above average. Really no complaints and I would stay again."
United States
Laura
The price is HK$792
HK$912 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles
An aerial view of a town with industrial buildings, roads, and green areas.

Frequently Asked Questions

What are some of the best holiday rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of St. Charles offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

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